Sanguinarine: its potential, as a liver toxic alkaloid present in the seeds ofArgemone mexicana View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-01

AUTHORS

R. R. Dalvi

ABSTRACT

The alkaloid sanguinarine reported to be responsible for several outbreaks of epidemic dropsy in the tropics was examined for its hepatotoxic potential in rats. The studies showed that a single i.p. dose (10 mg/kg) of sanguinarine not only increased the activity of SGPT and SGOT substantially but also caused a significant loss of microsomal cytochrome P-450 and benzphetamine N-demethylase activity. Furthermore, the treated rats exhibited considerable loss of body and liver weight, peritoneal edema and slightly enlarged livers with fibrinous material. Microscopic examination of the liver tissue showed progressive cellular degeneration and necrosis further substantiating that sanguinarine is a potential hepatotoxic alkaloid. More... »

PAGES

77-78

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02005884

DOI

http://dx.doi.org/10.1007/bf02005884

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046363548

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3967743


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