Further studies on the antinociceptive effects ofΔ acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

S. A. Doyle, S. H. Burstein, W. L. Dewey, S. P. Welch

ABSTRACT

The antinociceptive effects ofΔ (THC-7-oic) acid have been investigated further with particular regard to the influence of certain experimental parameters in the hot plate test. These included the degree of the thermal stimulus, the nature of the vehicle and a possible role for copper in the response. A temperature effect similar to that seen with nonsteroidalantiinflammatory drugs (NSAIDs) was observed, 55° produced observable antinociception, however, at a surface temperature of 58°C no drug effect was seen. Non-aqeous vehicles such as peanut oil increased the potency of THC-7-oic acid. Finally, the substitution of purified water for tap water reduced,the drug response which could be partially restored by adding copper to the purified drinking water. An increase in the inhibitory effect when copper was added was also seenin vitro in a cell culture model where the acid reduced prostaglandin synthesis induced by THC. Our findings suggest that THC-7-oic acid probably acts by mechanisms similar to the NSAIDs and that the above mentioned experimental conditions can greatly influence the outcome of studies with this agent. More... »

PAGES

157-163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf02003237

DOI

http://dx.doi.org/10.1007/bf02003237

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037000074

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2178317


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