Inhibition of chemiluminescence in granulocytes and alveolar macrophages by azelastine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

J. Schmidt, B. Kaufmann, R. Lindstaedt, I. Szelenyi

ABSTRACT

The effect of azelastine, an orally effective antiasthmatic antiallergic drug on the generation of oxygen-derived free radicals in phagocytes was investigated using different chemiluminescence-assays. The chemiluminescence (CL) of both human polymorphonuclear granulocytes (PMNL) and guinea-pig alveolar macrophages (AM) was induced either by phorbol myristate acetate (PMA) or zymosan and amplified either by lucigenin or DMNH (7-dimethylamino-naphthalene-1,2-dicarbonic-acidhydrazide). The inhibitory effect of azelastine was dependent on the inducer employed and the condition and type of cells used. Azelastine reduced PMA-induced CL concentration-dependently in both PMNL (IC30 = 3.9 microM) and AM (IC30 = 9.8 microM). In AM zymosan-induced CL was inhibited 21.7% by 10 microM azelastine, whereas in PMNL it remained unchanged up to 10 microM azelastine. Azelastine has a significantly stronger inhibitory effect (IC30 = 4.2 microM) on oxygen free radical generation in AM primed by fetal calf serum than in unprimed AM. Based on present results it is likely that azelastine inhibits oxygen-derived free radical generation by interaction with protein kinase C. More... »

PAGES

229-236

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01997613

DOI

http://dx.doi.org/10.1007/bf01997613

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031842282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2085139


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acridines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Dyes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guinea Pigs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Measurements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthalenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phthalazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Alveoli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetradecanoylphorbol Acetate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zymosan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Pharmacology, ASTA Pharma AG, Weism\u00fcller-Stra\u00dfe 45, D-6000, Frankfurt, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "J.", 
        "id": "sg:person.01166562456.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166562456.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pharmacology, ASTA Pharma AG, Weism\u00fcller-Stra\u00dfe 45, D-6000, Frankfurt, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaufmann", 
        "givenName": "B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pharmacology, ASTA Pharma AG, Weism\u00fcller-Stra\u00dfe 45, D-6000, Frankfurt, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindstaedt", 
        "givenName": "R.", 
        "id": "sg:person.01351124256.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351124256.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pharmacology, ASTA Pharma AG, Weism\u00fcller-Stra\u00dfe 45, D-6000, Frankfurt, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szelenyi", 
        "givenName": "I.", 
        "id": "sg:person.01037042175.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037042175.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0091-6749(87)90129-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000273787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(89)90112-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005183841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(83)90828-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008840127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1984.tb00100.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1984.tb00100.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.91.6.855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011681123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(86)90414-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013370933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(81)90267-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(81)90267-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-6989(86)90039-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015281509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1398-9995.1982.tb04115.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017138259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198411293112202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017943449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(84)90206-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023722549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(84)90206-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023722549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(89)90125-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026616278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci111249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029928364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(87)90461-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033778764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(87)90461-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033778764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-6749(86)80090-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035197794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01733781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333533", 
          "https://doi.org/10.1007/bf01733781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01733781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039333533", 
          "https://doi.org/10.1007/bf01733781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(86)90055-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042600624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(86)90055-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042600624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(85)90386-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043107869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4173(86)90005-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043958417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4173(86)90005-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043958417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-044080-1.50015-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044895060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/arrd.1987.135.6.1300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045899179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(89)90005-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047814945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-6749(89)90005-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047814945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(84)90072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048046600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(84)90072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048046600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0171-2985(88)80089-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048133325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.45.3.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079166204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000318686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079421847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079499395", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079510270", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080026862", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081662040", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081734798", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-11", 
    "datePublishedReg": "1990-11-01", 
    "description": "The effect of azelastine, an orally effective antiasthmatic antiallergic drug on the generation of oxygen-derived free radicals in phagocytes was investigated using different chemiluminescence-assays. The chemiluminescence (CL) of both human polymorphonuclear granulocytes (PMNL) and guinea-pig alveolar macrophages (AM) was induced either by phorbol myristate acetate (PMA) or zymosan and amplified either by lucigenin or DMNH (7-dimethylamino-naphthalene-1,2-dicarbonic-acidhydrazide). The inhibitory effect of azelastine was dependent on the inducer employed and the condition and type of cells used. Azelastine reduced PMA-induced CL concentration-dependently in both PMNL (IC30 = 3.9 microM) and AM (IC30 = 9.8 microM). In AM zymosan-induced CL was inhibited 21.7% by 10 microM azelastine, whereas in PMNL it remained unchanged up to 10 microM azelastine. Azelastine has a significantly stronger inhibitory effect (IC30 = 4.2 microM) on oxygen free radical generation in AM primed by fetal calf serum than in unprimed AM. Based on present results it is likely that azelastine inhibits oxygen-derived free radical generation by interaction with protein kinase C.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01997613", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1012133", 
        "issn": [
          "1023-3830", 
          "1420-908X"
        ], 
        "name": "Inflammation Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3-4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Inhibition of chemiluminescence in granulocytes and alveolar macrophages by azelastine", 
    "pagination": "229-236", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "97b0a6f220d1282e29ccb9ae1bfb5b5069522812673ad146994e59ce150ec6bd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2085139"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0213341"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01997613"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031842282"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01997613", 
      "https://app.dimensions.ai/details/publication/pub.1031842282"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000357_0000000357/records_99289_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01997613"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01997613'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01997613'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01997613'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01997613'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      76 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01997613 schema:about N10069a01e0544d7390eef6d322a33aab
2 N119c702b08f04b23a917ac2d1df4b8ab
3 N3f055eb29dc2448ba02c8e2bd24817fe
4 N4777f2be444d4da19064c8f6040e495e
5 N592b147ee2544b119b6289cd7e918feb
6 N5bb357da7e0c4c93a805ce77366bbfee
7 N6e1cf434facf45a288a2edfc6e8ddcf5
8 N7046df73e8c249da9feef22d0afa1737
9 N70b2a3147a6d4988ad2ce40c1e2fd7b9
10 N758f42ed5a884a40bdd5c19610d14f01
11 N98165a1c3f124ecf96a36efce27b44f8
12 Nacdcd30db74849dcb17f8c56df9ac441
13 Nb56913056e534b0f97f2f497b76eee82
14 Nc1012f947e7c4dd3adc302b8a4f923a7
15 Nd5e218fd44b241979911b545b25be666
16 Nf4b95f86220649328847184775a006d7
17 anzsrc-for:03
18 anzsrc-for:0305
19 schema:author N4bff036b216340079e3b32f930c2b731
20 schema:citation sg:pub.10.1007/bf01733781
21 https://app.dimensions.ai/details/publication/pub.1079499395
22 https://app.dimensions.ai/details/publication/pub.1079510270
23 https://app.dimensions.ai/details/publication/pub.1080026862
24 https://app.dimensions.ai/details/publication/pub.1081662040
25 https://app.dimensions.ai/details/publication/pub.1081734798
26 https://doi.org/10.1002/jlb.45.3.231
27 https://doi.org/10.1016/0006-291x(83)90828-8
28 https://doi.org/10.1016/0006-2952(84)90072-8
29 https://doi.org/10.1016/0022-1759(84)90206-0
30 https://doi.org/10.1016/0022-1759(87)90461-3
31 https://doi.org/10.1016/0031-6989(86)90039-1
32 https://doi.org/10.1016/0091-6749(85)90386-0
33 https://doi.org/10.1016/0091-6749(86)90414-8
34 https://doi.org/10.1016/0091-6749(87)90129-1
35 https://doi.org/10.1016/0091-6749(89)90005-5
36 https://doi.org/10.1016/0091-6749(89)90112-7
37 https://doi.org/10.1016/0091-6749(89)90125-5
38 https://doi.org/10.1016/0304-4165(81)90267-1
39 https://doi.org/10.1016/0304-4165(86)90055-3
40 https://doi.org/10.1016/0304-4173(86)90005-4
41 https://doi.org/10.1016/b978-0-12-044080-1.50015-8
42 https://doi.org/10.1016/s0091-6749(86)80090-2
43 https://doi.org/10.1016/s0171-2985(88)80089-5
44 https://doi.org/10.1056/nejm198411293112202
45 https://doi.org/10.1111/j.1398-9995.1982.tb04115.x
46 https://doi.org/10.1111/j.1699-0463.1984.tb00100.x
47 https://doi.org/10.1159/000318686
48 https://doi.org/10.1164/arrd.1987.135.6.1300
49 https://doi.org/10.1172/jci111249
50 https://doi.org/10.1378/chest.91.6.855
51 schema:datePublished 1990-11
52 schema:datePublishedReg 1990-11-01
53 schema:description The effect of azelastine, an orally effective antiasthmatic antiallergic drug on the generation of oxygen-derived free radicals in phagocytes was investigated using different chemiluminescence-assays. The chemiluminescence (CL) of both human polymorphonuclear granulocytes (PMNL) and guinea-pig alveolar macrophages (AM) was induced either by phorbol myristate acetate (PMA) or zymosan and amplified either by lucigenin or DMNH (7-dimethylamino-naphthalene-1,2-dicarbonic-acidhydrazide). The inhibitory effect of azelastine was dependent on the inducer employed and the condition and type of cells used. Azelastine reduced PMA-induced CL concentration-dependently in both PMNL (IC30 = 3.9 microM) and AM (IC30 = 9.8 microM). In AM zymosan-induced CL was inhibited 21.7% by 10 microM azelastine, whereas in PMNL it remained unchanged up to 10 microM azelastine. Azelastine has a significantly stronger inhibitory effect (IC30 = 4.2 microM) on oxygen free radical generation in AM primed by fetal calf serum than in unprimed AM. Based on present results it is likely that azelastine inhibits oxygen-derived free radical generation by interaction with protein kinase C.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N450d97448bb5450aaa19108d2df675f0
58 N932b776fa02245fa99cae73f28a0f572
59 sg:journal.1012133
60 schema:name Inhibition of chemiluminescence in granulocytes and alveolar macrophages by azelastine
61 schema:pagination 229-236
62 schema:productId N1a3694519402488480dcda77c0d8188a
63 N1cf7af7110b14e43bccdfd2245ad638f
64 N2f9159965f0943a9918cc4e5d1d081b0
65 Na80e855c73164f4b8e2e4a608975f37f
66 Nc6f2556c5a044cad9c7f5076da4dd553
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031842282
68 https://doi.org/10.1007/bf01997613
69 schema:sdDatePublished 2019-04-11T11:29
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N0768ee0d0be24aa4b6c3bec1caa261e9
72 schema:url http://link.springer.com/10.1007/BF01997613
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0768ee0d0be24aa4b6c3bec1caa261e9 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N10069a01e0544d7390eef6d322a33aab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Tetradecanoylphorbol Acetate
80 rdf:type schema:DefinedTerm
81 N119c702b08f04b23a917ac2d1df4b8ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Humans
83 rdf:type schema:DefinedTerm
84 N1a3694519402488480dcda77c0d8188a schema:name nlm_unique_id
85 schema:value 0213341
86 rdf:type schema:PropertyValue
87 N1ca1921bf1084350afc32112b3efb374 schema:name Department of Pharmacology, ASTA Pharma AG, Weismüller-Straße 45, D-6000, Frankfurt, FRG
88 rdf:type schema:Organization
89 N1cf7af7110b14e43bccdfd2245ad638f schema:name readcube_id
90 schema:value 97b0a6f220d1282e29ccb9ae1bfb5b5069522812673ad146994e59ce150ec6bd
91 rdf:type schema:PropertyValue
92 N2f9159965f0943a9918cc4e5d1d081b0 schema:name dimensions_id
93 schema:value pub.1031842282
94 rdf:type schema:PropertyValue
95 N3f055eb29dc2448ba02c8e2bd24817fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Guinea Pigs
97 rdf:type schema:DefinedTerm
98 N450d97448bb5450aaa19108d2df675f0 schema:issueNumber 3-4
99 rdf:type schema:PublicationIssue
100 N4777f2be444d4da19064c8f6040e495e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Kinetics
102 rdf:type schema:DefinedTerm
103 N4bff036b216340079e3b32f930c2b731 rdf:first sg:person.01166562456.00
104 rdf:rest N96704eab28e64405a0e0dbd632a43cde
105 N5130c6601f4b4f789a6c4638a426a1a7 schema:affiliation Nd1cc42a6ba24419b932638f2edf15b60
106 schema:familyName Kaufmann
107 schema:givenName B.
108 rdf:type schema:Person
109 N592b147ee2544b119b6289cd7e918feb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hydrazines
111 rdf:type schema:DefinedTerm
112 N5bb357da7e0c4c93a805ce77366bbfee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Granulocytes
114 rdf:type schema:DefinedTerm
115 N697f18f471184874830d3ebd2e06c11d rdf:first sg:person.01351124256.71
116 rdf:rest Nce02ab4537154c02808c00058fe185a7
117 N6e1cf434facf45a288a2edfc6e8ddcf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Fluorescent Dyes
119 rdf:type schema:DefinedTerm
120 N7046df73e8c249da9feef22d0afa1737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Acridines
122 rdf:type schema:DefinedTerm
123 N70b2a3147a6d4988ad2ce40c1e2fd7b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Adult
125 rdf:type schema:DefinedTerm
126 N758f42ed5a884a40bdd5c19610d14f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Naphthalenes
128 rdf:type schema:DefinedTerm
129 N932b776fa02245fa99cae73f28a0f572 schema:volumeNumber 31
130 rdf:type schema:PublicationVolume
131 N96704eab28e64405a0e0dbd632a43cde rdf:first N5130c6601f4b4f789a6c4638a426a1a7
132 rdf:rest N697f18f471184874830d3ebd2e06c11d
133 N98165a1c3f124ecf96a36efce27b44f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Zymosan
135 rdf:type schema:DefinedTerm
136 Na80e855c73164f4b8e2e4a608975f37f schema:name pubmed_id
137 schema:value 2085139
138 rdf:type schema:PropertyValue
139 Nacdcd30db74849dcb17f8c56df9ac441 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Macrophages
141 rdf:type schema:DefinedTerm
142 Nb56913056e534b0f97f2f497b76eee82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Luminescent Measurements
144 rdf:type schema:DefinedTerm
145 Nb84e4e8ca1614fe993b72a84c2ba5343 schema:name Department of Pharmacology, ASTA Pharma AG, Weismüller-Straße 45, D-6000, Frankfurt, FRG
146 rdf:type schema:Organization
147 Nc1012f947e7c4dd3adc302b8a4f923a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Pulmonary Alveoli
149 rdf:type schema:DefinedTerm
150 Nc6f2556c5a044cad9c7f5076da4dd553 schema:name doi
151 schema:value 10.1007/bf01997613
152 rdf:type schema:PropertyValue
153 Nce02ab4537154c02808c00058fe185a7 rdf:first sg:person.01037042175.46
154 rdf:rest rdf:nil
155 Nd1cc42a6ba24419b932638f2edf15b60 schema:name Department of Pharmacology, ASTA Pharma AG, Weismüller-Straße 45, D-6000, Frankfurt, FRG
156 rdf:type schema:Organization
157 Nd5e218fd44b241979911b545b25be666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Phthalazines
159 rdf:type schema:DefinedTerm
160 Nf4b95f86220649328847184775a006d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Animals
162 rdf:type schema:DefinedTerm
163 Nfff21bfd67e842e0ac29e0f8c4f18ba9 schema:name Department of Pharmacology, ASTA Pharma AG, Weismüller-Straße 45, D-6000, Frankfurt, FRG
164 rdf:type schema:Organization
165 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
166 schema:name Chemical Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
169 schema:name Organic Chemistry
170 rdf:type schema:DefinedTerm
171 sg:journal.1012133 schema:issn 1023-3830
172 1420-908X
173 schema:name Inflammation Research
174 rdf:type schema:Periodical
175 sg:person.01037042175.46 schema:affiliation Nfff21bfd67e842e0ac29e0f8c4f18ba9
176 schema:familyName Szelenyi
177 schema:givenName I.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037042175.46
179 rdf:type schema:Person
180 sg:person.01166562456.00 schema:affiliation Nb84e4e8ca1614fe993b72a84c2ba5343
181 schema:familyName Schmidt
182 schema:givenName J.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166562456.00
184 rdf:type schema:Person
185 sg:person.01351124256.71 schema:affiliation N1ca1921bf1084350afc32112b3efb374
186 schema:familyName Lindstaedt
187 schema:givenName R.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351124256.71
189 rdf:type schema:Person
190 sg:pub.10.1007/bf01733781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039333533
191 https://doi.org/10.1007/bf01733781
192 rdf:type schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079499395 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1079510270 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1080026862 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1081662040 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1081734798 schema:CreativeWork
198 https://doi.org/10.1002/jlb.45.3.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079166204
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0006-291x(83)90828-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008840127
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0006-2952(84)90072-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048046600
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0022-1759(84)90206-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023722549
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0022-1759(87)90461-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033778764
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0031-6989(86)90039-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015281509
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0091-6749(85)90386-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043107869
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0091-6749(86)90414-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013370933
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0091-6749(87)90129-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000273787
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/0091-6749(89)90005-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047814945
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0091-6749(89)90112-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005183841
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0091-6749(89)90125-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026616278
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0304-4165(81)90267-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566447
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0304-4165(86)90055-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042600624
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0304-4173(86)90005-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043958417
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/b978-0-12-044080-1.50015-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044895060
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0091-6749(86)80090-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035197794
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0171-2985(88)80089-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048133325
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejm198411293112202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017943449
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1398-9995.1982.tb04115.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017138259
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1111/j.1699-0463.1984.tb00100.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010434808
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1159/000318686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079421847
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1164/arrd.1987.135.6.1300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045899179
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1172/jci111249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029928364
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1378/chest.91.6.855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681123
247 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...