Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-06

AUTHORS

J. M. Carlin, Y. Ozaki, G. I. Byrne, R. R. Brown, E. C. Borden

ABSTRACT

Indoleamine 2,3-dioxygenase (IDO) is an interferon (IFN)-induced protein that initiates the metabolism of tryptophan along the kynurenine pathway. Although IDO can be induced by IFN-gamma in many cell types, only mononuclear phagocytes have been shown to be induced to decyclize tryptophan by all three IFN classes. Since tryptophan is an essential amino acid necessary for a variety of metabolic processes, depletion of available tryptophan may be an important mechanism for control of rapidly-dividing microbial pathogens and tumors. The purpose of this review is to present evidence that documents the effects of IFN-induced IDO on prokaryotic and eukaryotic pathogens, as well as on a variety of tumor cell lines. More... »

PAGES

535-541

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01990503

DOI

http://dx.doi.org/10.1007/bf01990503

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012920621

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2472288


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01990503'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01990503'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01990503'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01990503'


 

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