Safety and efficacy of a combined oral contraceptive: Gestodene 75 μg plus ethinyl estradiol 30 μg in Mexican women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

J. Garza-Flores, V. Valles de Bourges, M. Martínez, L. Vázquez-Estrada, S. Bassol, R. Recio, G. Pérez-Palacios

ABSTRACT

An open prospective clinical trial designed to evaluate the efficacy and safety of the combined hormonal oral contraceptive (OC) containing 75 μg gestodene plus 30 μg ethinyl estradiol was undertaken in a Mexican population. Sixty-nine healthy women of reproductive age took part in the study for a total of 627 woman-months of observation. The combination of gestodene and ethinyl estradiol proved its effectiveness in preventing pregnancy during the study. Side-effects were minimal and regular endometrial bleeding patterns were observed during one year of continuous use of this OC preparation. The discontinuation rate for medical reasons was 11.6% at one year. Among a sample of 10 women, the gestodene/ethinyl estradiol combination did not induce significant changes in the serum concentration of total cholesterol and LDL cholesterol after 12 months of continuous administration. An increase in serum triglycerides and HDL cholesterol was observed; this effect could be atributed to a lack of androgenic and/or the intrinsic estrogenic behavior of gestodene.It can be concluded that this preparation is highly effective as a combined oral contraceptive; it is well tolerated and might offer some advantages with respect to other oral contraceptive combinations in its short- and medium-term impact on lipid metabolism. More... »

PAGES

19-26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01986525

DOI

http://dx.doi.org/10.1007/bf01986525

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004489163

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8030449


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