Cortisol resistant RPMI-1788 lymphocytes become sensitive to cortisol subsequent to a 24-h incubation period in medium containing purified human transcortin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-08

AUTHORS

L. Amaral, S. Werthamer

ABSTRACT

RPMI-1788 lymphocytes (a human cell line) are resistant to cortisol in vitro. Prior incubation for a minimum of 24 h in a medium which contains purified human transcortin at a concentration of 50 micrograms/ml renders these cells sensitive to the inhibitory action of cortisol as regards the synthesis of DNA. Only the transcortin-exposed cells contain a cortisol binding species whose sedimentation behavior in a sucrose gradient is identical to that of transcortin. More... »

PAGES

903-904

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01985705

DOI

http://dx.doi.org/10.1007/bf01985705

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043496035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7286153


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