Bactericidal activity of daptomycin against vancomycin-resistantEnterococcus faecium in an in vitro pharmacokinetic model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-12

AUTHORS

E. Bingen, C. Doit, N. Lambert-Zechovsky, M. Tod, O. Petitjean, F. Bourgeois, P. Mariani-Kurkdjian

ABSTRACT

A dynamic in vitro model was used to determine the killing kinetics of daptomycin against 15 vancomycin-resistant clinical isolates of Enterococcus faecium. Concentration profiles simulating those observed in serum following administration of both low-dose (2 mg/kg) and high-dose (6 mg/kg) daptomycin were bactericidal within 5.5 and 2.8 h, respectively. In contrast, when albumin was added to the growth medium, the corresponding bacterial killing times were slowed to greater than 24 h and 7 h; these results suggest that in the clinical setting, daptomycin dosages of approximately 6 mg/kg are required to achieve bactericidal activity against vancomycin-resistant Enterococcus faecium. More... »

PAGES

1062-1065

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01984930

DOI

http://dx.doi.org/10.1007/bf01984930

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025086889

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1666362


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