Dissemination in five French hospitals ofKlebsiella pneumoniae serotype K25 harbouring a new transferable enzymatic resistance to third generation cephalosporins and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

A. Bure, P. Legrand, G. Arlet, V. Jarlier, G. Paul, A. Philippon

ABSTRACT

A strain ofKlebsiella pneumoniae K25 resistant to newerβ-lactam drugs was isolated in clusters in five hospitals in the Paris area. The MICs of ceftazidime and aztreonam (⩾128 mg/l) were higher than that of cefotaxime (16 mg/l) for the strain but when measured in the presence of clavulanic acid, they were ⩽1 mg/l. The donor strains and derivatives produced aβ-lactamase with a pI of 7.75–7.8 and hydrolysing activity against a wide spectrum ofβ-lactams similar to that of SHV-2 and SHV-3, but with significant hydrolysis of ceftazidime. This new enzyme could be designated SHV-4. More... »

PAGES

780-782

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01975048

DOI

http://dx.doi.org/10.1007/bf01975048

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047073148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3145863


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