Isolation ofEnterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

M. A. Mellencamp, J. S. Roccaforte, L. C. Preheim, C. C. Sanders, C. A. Anene, M. J. Bittner

ABSTRACT

This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum beta-lactams despite constitutive production of high levels of beta-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein. More... »

PAGES

827-830

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01967384

DOI

http://dx.doi.org/10.1007/bf01967384

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003426044

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2086219


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