Killing kinetics of cefuroxime againstStreptococcus pneumoniae in an in vitro model simulating serum concentration profiles after intramuscular administration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-04

AUTHORS

E. Bingen, C. Doit, R. Farinotti, N. Lambert-Zechovsky

ABSTRACT

The killing kinetics of cefuroxime against 25 Streptococcus pneumoniae isolates with penicillin MICs of < 0.1, 0.1-1.0 and 2 mg/l were studied in an in vitro model simulating the serum concentration profile in healthy adults following a single intramuscular injection of 500 mg. Cefuroxime was bactericidal against the isolates with exquisite or slightly diminished susceptibility to penicillin (-4 and -3.9 log10 cfu/ml killing, respectively) during the 6 h incubation period. In contrast, there was only a 2.8 log10 cfu/ml reduction in the initial inoculum of six of the eight isolates resistant to penicillin (MIC 2 mg/l). The two remaining penicillin-resistant isolates (cefuroxime MIC 8 mg/l) only showed a 2 log10 cfu reduction in the initial inoculum. More... »

PAGES

297-299

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01967263

DOI

http://dx.doi.org/10.1007/bf01967263

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053274135

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8513820


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