Effects of fluconazole on the sterol and carbohydrate composition of four species ofCandida View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-02

AUTHORS

M. Pfaller, J. Riley

ABSTRACT

The effects of fluconazole, a bis-triazole antifungal agent, on the sterol and carbohydrate composition ofCandida albicans, Candida tropicalis, Candida krusei andCandida parapsilosis were investigated. Exposure ofCandida species to fluconazole resulted in a profound depletion of ergosterol with a corresponding increase in lanosterol content versus control cells. Carbohydrate analysis revealed a significant increase in chitin and either a decrease(Candida albicans, Candida tropicalis andCandida parapsilosis) or an increase(Candida krusei) in glucan content in fluconazole-treated cells. The decreased ergosterol and increased lanosterol content is consistnet with 14-alpha-demethylase inhibition by fluconazole. The increase in cell wall chitin is most likely due to deregulation of chitin synthesis secondary to ergosterol depletion in the cell membrane. Because chitin, glucan and ergosterol are critical components of the fungal cell, perturbation of the production and localization of these components by fluconazole is likely to contribute to the selective toxicity of this compound toCandida species and other fungi. More... »

PAGES

152-156

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01967067

DOI

http://dx.doi.org/10.1007/bf01967067

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039139948

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1396728


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candida", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candida albicans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbohydrates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Wall", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chitin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ergosterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluconazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lanosterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mannans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sterols", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, Oregon, USA", 
          "id": "http://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA", 
            "Department of Pathology, 273 MRC, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA", 
            "Department of Pathology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, Oregon, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfaller", 
        "givenName": "M.", 
        "id": "sg:person.01153415220.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153415220.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riley", 
        "givenName": "J.", 
        "id": "sg:person.01134653121.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134653121.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-4613-9547-8_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039177848", 
          "https://doi.org/10.1007/978-1-4613-9547-8_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4612-3730-3_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040933696", 
          "https://doi.org/10.1007/978-1-4612-3730-3_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01975172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000131955", 
          "https://doi.org/10.1007/bf01975172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-011-6014-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006316937", 
          "https://doi.org/10.1007/978-94-011-6014-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00443651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017492697", 
          "https://doi.org/10.1007/bf00443651"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-02", 
    "datePublishedReg": "1992-02-01", 
    "description": "The effects of fluconazole, a bis-triazole antifungal agent, on the sterol and carbohydrate composition ofCandida albicans, Candida tropicalis, Candida krusei andCandida parapsilosis were investigated. Exposure ofCandida species to fluconazole resulted in a profound depletion of ergosterol with a corresponding increase in lanosterol content versus control cells. Carbohydrate analysis revealed a significant increase in chitin and either a decrease(Candida albicans, Candida tropicalis andCandida parapsilosis) or an increase(Candida krusei) in glucan content in fluconazole-treated cells. The decreased ergosterol and increased lanosterol content is consistnet with 14-alpha-demethylase inhibition by fluconazole. The increase in cell wall chitin is most likely due to deregulation of chitin synthesis secondary to ergosterol depletion in the cell membrane. Because chitin, glucan and ergosterol are critical components of the fungal cell, perturbation of the production and localization of these components by fluconazole is likely to contribute to the selective toxicity of this compound toCandida species and other fungi.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01967067", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093599", 
        "issn": [
          "0934-9723", 
          "1435-4373"
        ], 
        "name": "European Journal of Clinical Microbiology & Infectious Diseases", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "cell wall chitin", 
      "fungal cells", 
      "chitin synthesis", 
      "lanosterol content", 
      "cell membrane", 
      "control cells", 
      "selective toxicity", 
      "ergosterol", 
      "species", 
      "chitin", 
      "cells", 
      "sterols", 
      "carbohydrate analysis", 
      "ofCandida albicans", 
      "Candida tropicalis", 
      "carbohydrate composition", 
      "glucan content", 
      "fungi", 
      "depletion", 
      "critical component", 
      "deregulation", 
      "glucan", 
      "membrane", 
      "antifungal agents", 
      "corresponding increase", 
      "localization", 
      "tropicalis", 
      "albicans", 
      "inhibition", 
      "Candida", 
      "content", 
      "components", 
      "production", 
      "profound depletion", 
      "toxicity", 
      "parapsilosis", 
      "composition", 
      "increase", 
      "significant increase", 
      "perturbations", 
      "synthesis", 
      "effect", 
      "bis-triazole antifungal agent", 
      "analysis", 
      "agents", 
      "fluconazole", 
      "effect of fluconazole"
    ], 
    "name": "Effects of fluconazole on the sterol and carbohydrate composition of four species ofCandida", 
    "pagination": "152-156", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039139948"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01967067"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1396728"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01967067", 
      "https://app.dimensions.ai/details/publication/pub.1039139948"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_221.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01967067"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01967067'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01967067'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01967067'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01967067'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      21 PREDICATES      89 URIs      76 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01967067 schema:about N010e69c72f7140709ec6f38cde21350f
2 N3b49d26623914f5080f232a37d97e06b
3 Na0bfd6cf38a343be8e70e1573745be81
4 Nbd927e6b63a343849a8dda55c15c7300
5 Nc8a1868534e4442094d0bfdbe09ed652
6 Ne20e7e54832b449da097dd3293032f9d
7 Ne85c9dc0021f4fe28041f1b44815c16d
8 Nea9427d1b51a4bcfac0b654165569e1c
9 Neb688b8b3475405d95810cd637a8330c
10 Nf7240558986e4ad6980590efe100f889
11 Nffef594064bb463b9b9793b71cd99933
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author Nedcdac9120b247fd939b916e0a1bdc7a
15 schema:citation sg:pub.10.1007/978-1-4612-3730-3_1
16 sg:pub.10.1007/978-1-4613-9547-8_12
17 sg:pub.10.1007/978-94-011-6014-8
18 sg:pub.10.1007/bf00443651
19 sg:pub.10.1007/bf01975172
20 schema:datePublished 1992-02
21 schema:datePublishedReg 1992-02-01
22 schema:description The effects of fluconazole, a bis-triazole antifungal agent, on the sterol and carbohydrate composition ofCandida albicans, Candida tropicalis, Candida krusei andCandida parapsilosis were investigated. Exposure ofCandida species to fluconazole resulted in a profound depletion of ergosterol with a corresponding increase in lanosterol content versus control cells. Carbohydrate analysis revealed a significant increase in chitin and either a decrease(Candida albicans, Candida tropicalis andCandida parapsilosis) or an increase(Candida krusei) in glucan content in fluconazole-treated cells. The decreased ergosterol and increased lanosterol content is consistnet with 14-alpha-demethylase inhibition by fluconazole. The increase in cell wall chitin is most likely due to deregulation of chitin synthesis secondary to ergosterol depletion in the cell membrane. Because chitin, glucan and ergosterol are critical components of the fungal cell, perturbation of the production and localization of these components by fluconazole is likely to contribute to the selective toxicity of this compound toCandida species and other fungi.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N3bfb6406b47e42f88b8dff39573934c7
26 N3e276e8857db4af5bf182a40edfb5a0c
27 sg:journal.1093599
28 schema:keywords Candida
29 Candida tropicalis
30 agents
31 albicans
32 analysis
33 antifungal agents
34 bis-triazole antifungal agent
35 carbohydrate analysis
36 carbohydrate composition
37 cell membrane
38 cell wall chitin
39 cells
40 chitin
41 chitin synthesis
42 components
43 composition
44 content
45 control cells
46 corresponding increase
47 critical component
48 depletion
49 deregulation
50 effect
51 effect of fluconazole
52 ergosterol
53 fluconazole
54 fungal cells
55 fungi
56 glucan
57 glucan content
58 increase
59 inhibition
60 lanosterol content
61 localization
62 membrane
63 ofCandida albicans
64 parapsilosis
65 perturbations
66 production
67 profound depletion
68 selective toxicity
69 significant increase
70 species
71 sterols
72 synthesis
73 toxicity
74 tropicalis
75 schema:name Effects of fluconazole on the sterol and carbohydrate composition of four species ofCandida
76 schema:pagination 152-156
77 schema:productId N367355cfea6b4898bdb91ede7d5dda35
78 N39eff940db6b433daffde965dbff91e8
79 N91877effec0c45b98891d7c1fba5a3d6
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039139948
81 https://doi.org/10.1007/bf01967067
82 schema:sdDatePublished 2022-08-04T16:50
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N47af3689a09e44e1b7314c5f218c9ed6
85 schema:url https://doi.org/10.1007/bf01967067
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N010e69c72f7140709ec6f38cde21350f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mannans
91 rdf:type schema:DefinedTerm
92 N367355cfea6b4898bdb91ede7d5dda35 schema:name pubmed_id
93 schema:value 1396728
94 rdf:type schema:PropertyValue
95 N39eff940db6b433daffde965dbff91e8 schema:name dimensions_id
96 schema:value pub.1039139948
97 rdf:type schema:PropertyValue
98 N3b49d26623914f5080f232a37d97e06b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Candida
100 rdf:type schema:DefinedTerm
101 N3bfb6406b47e42f88b8dff39573934c7 schema:issueNumber 2
102 rdf:type schema:PublicationIssue
103 N3e276e8857db4af5bf182a40edfb5a0c schema:volumeNumber 11
104 rdf:type schema:PublicationVolume
105 N47af3689a09e44e1b7314c5f218c9ed6 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N5b443f27137b4ee2bdad21645f681c4a rdf:first sg:person.01134653121.42
108 rdf:rest rdf:nil
109 N91877effec0c45b98891d7c1fba5a3d6 schema:name doi
110 schema:value 10.1007/bf01967067
111 rdf:type schema:PropertyValue
112 Na0bfd6cf38a343be8e70e1573745be81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Carbohydrates
114 rdf:type schema:DefinedTerm
115 Nbd927e6b63a343849a8dda55c15c7300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Fluconazole
117 rdf:type schema:DefinedTerm
118 Nc8a1868534e4442094d0bfdbe09ed652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Glucans
120 rdf:type schema:DefinedTerm
121 Ne20e7e54832b449da097dd3293032f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Ergosterol
123 rdf:type schema:DefinedTerm
124 Ne85c9dc0021f4fe28041f1b44815c16d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cell Wall
126 rdf:type schema:DefinedTerm
127 Nea9427d1b51a4bcfac0b654165569e1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Sterols
129 rdf:type schema:DefinedTerm
130 Neb688b8b3475405d95810cd637a8330c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Lanosterol
132 rdf:type schema:DefinedTerm
133 Nedcdac9120b247fd939b916e0a1bdc7a rdf:first sg:person.01153415220.67
134 rdf:rest N5b443f27137b4ee2bdad21645f681c4a
135 Nf7240558986e4ad6980590efe100f889 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Candida albicans
137 rdf:type schema:DefinedTerm
138 Nffef594064bb463b9b9793b71cd99933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Chitin
140 rdf:type schema:DefinedTerm
141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biological Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biochemistry and Cell Biology
146 rdf:type schema:DefinedTerm
147 sg:journal.1093599 schema:issn 0934-9723
148 1435-4373
149 schema:name European Journal of Clinical Microbiology & Infectious Diseases
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.01134653121.42 schema:affiliation grid-institutes:None
153 schema:familyName Riley
154 schema:givenName J.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134653121.42
156 rdf:type schema:Person
157 sg:person.01153415220.67 schema:affiliation grid-institutes:grid.5288.7
158 schema:familyName Pfaller
159 schema:givenName M.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153415220.67
161 rdf:type schema:Person
162 sg:pub.10.1007/978-1-4612-3730-3_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040933696
163 https://doi.org/10.1007/978-1-4612-3730-3_1
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/978-1-4613-9547-8_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039177848
166 https://doi.org/10.1007/978-1-4613-9547-8_12
167 rdf:type schema:CreativeWork
168 sg:pub.10.1007/978-94-011-6014-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006316937
169 https://doi.org/10.1007/978-94-011-6014-8
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/bf00443651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017492697
172 https://doi.org/10.1007/bf00443651
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/bf01975172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000131955
175 https://doi.org/10.1007/bf01975172
176 rdf:type schema:CreativeWork
177 grid-institutes:None schema:alternateName Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA
178 schema:name Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA
179 rdf:type schema:Organization
180 grid-institutes:grid.5288.7 schema:alternateName Department of Pathology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, Oregon, USA
181 schema:name Department of Pathology, 273 MRC, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA
182 Department of Pathology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, 97201-3098, Portland, Oregon, USA
183 Veterans Affairs Medical Center, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...