Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-03

AUTHORS

C. Leport, C. Tournerie, G. Raguin, J. Fernandez-Martin, T. Niyongabo, J. L. Vildé

ABSTRACT

To assess potential interactions of multiple drug regimens administered to patients with AIDS for toxicity and efficacy, we reviewed the charts of 35 patients on maintenance therapy for toxoplasmosis. Seven relapses of toxoplasmosis occurred in 6 of 35 (17 %) patients, and seven episodes of pneumocystosis occurred in 6 of 35 (17 %) patients. Four relapses of toxoplasmosis and 5 relapses of pneumocystosis were seen in 20 patients treated with pyrimethamine/clindamycin; 2 relapses of toxoplasmosis and 2 relapses of pneumocystosis were seen in 11 patients treated with pyrimethamine alone, and 1 relapse of toxoplasmosis was seen in 13 patients treated with pyrimethamine/sulfadiazine. Adverse effects were related to pyrimethamine in 10 patients, to clindamycin in 7 patients, and to sulfadiazine in 8 patients. These results must be compared with those of prospective trials to determine the efficacy and safety of various maintenance regimens. More... »

PAGES

191-193

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01964460

DOI

http://dx.doi.org/10.1007/bf01964460

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043180934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2060528


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