Killing kinetics of five orally administered antibiotics at clinically achievable concentrations againstmoraxella catarrhalis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-10

AUTHORS

E. Bingen, F. Bourgeois, H. Chardon, C. Doit, N. Lambert-Zechovsky

ABSTRACT

Time-kill kinetic studies were used to measure the bactericidal activity of amoxicillin/clavulanic acid (in a new form for pediatric use), cefaclor, cefuroxime, cefixime and erythromycin against 30 beta-lactamase producing Moraxella catarrhalis strains. Antibiotics were tested at the mean maximum serum concentration observed after administration of a standard dose and at 0.5 x Cmax, 0.33 x Cmax and 0.25 x Cmax. A 2 log10 reduction in colony counts was obtained with the Cmax of amoxicillin/clavulanic acid and cefixime after 5 h of incubation. After 24 h of incubation a decrease of 3 and 4 log was observed with cefixime and amoxicillin/clavulanic acid respectively. At 0.5 x Cmax and 0.33 x Cmax, bactericidal activity was obtained only with amoxicillin/clavulanic acid. More... »

PAGES

923-926

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01962375

DOI

http://dx.doi.org/10.1007/bf01962375

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000048607

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1486888


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