C-erbB-2 protein in the sera of breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-06

AUTHORS

Tatsuhiko Narita, Hiroomi Funahashi, Yasuyuki Satoh, Hiroshi Takagi

ABSTRACT

The c-erbB-2 protein was measured in sera of patients with breast cancer or benign breast diseases to study the significance of this protein as a tumor marker. The mean value and positive rate for this protein (assuming 20U/ml as the cut-off value) were 11.8 U/ml (0%) in benign breast disease (n = 30), 11.8 U/ml (3.1%) in stage I/II primary breast cancer (n = 64), 38.2 U/ml (29.4%) in stage III/IV primary breast cancer (n = 17), 17.9 U/ml (33.3%) in locally recurrent breast cancer (n = 12), 298.4 U/ml (51.0%) in recurrent breast cancer with distant metastases (n = 51), and 12.9 U/ml (0%) in those with no evidence of recurrence (n = 57). Thus, the serum c-erbB-2 protein level was significantly higher in the distant metastatic group. In patients with distant metastases, there was a close association between expression of c-erbB-2 protein in the primary tumor and the serum c-erbB-2 protein level. On the basis of these results, serum c-erbB-2 protein was thought to be useful as a tumor marker for postoperative monitoring of breast cancer, especially in patients positive for expression of this protein in primary cancer tissue. More... »

PAGES

97-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01961242

DOI

http://dx.doi.org/10.1007/bf01961242

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045749770

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8095169


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