Pharmacokinėtics of intravenous and oral cyclophosphamide in the presence of methotrexate and fluorouracil View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-10

AUTHORS

E. A. De Bruijn, P. H. TH. J Slee, A. T. Van Oosterom, D. W. Lameijer, K. J. Roozendaal, U. R. Tjaden

ABSTRACT

Cyclophosphamide was administered to 12 breast cancer patients in combination with methotrexate and fluorouracil. Doses prescribed were cyclophosphamide 75 mg/m2, methotrexate 30 mg/m2 and fluorouracil 500 mg/m2 (per square meter body surface). Cyclophosphamide was administered intravenously and orally in aqueous solutions and in tablets in a randomized cross-over trial. Methotrexate and fluorouracil were administered intravenously, methotrexate was given first and then fluorouracil. Assays of cyclophosphamide in blood plasma were performed by capillary gas chromatography. Data of mean bioavailability of cyclophosphamide administered by tablets were suggestive of sufficient absorption. In 2 patients, however, a lower bioavailability of cyclophosphamide was demonstrated. Intra-individual differences in the terminal slope of the plasma decay curves after intravenous and oral administration in some patients decreased the calculated bioavailability of cyclophosphamide, if these values were included in the calculation of cyclophosphamide bioavailability. Compared with the administration of the solutions peak times, lag-times and mean absorption times of cyclophosphamide given in tablets were markedly prolonged. It is concluded that interactions between cyclophosphamide and methotrexate and/or fluorouracil after oral dosing as tablets are different from interactions observed after intravenous administration of cyclosphosphamide. More... »

PAGES

200-206

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01956871

DOI

http://dx.doi.org/10.1007/bf01956871

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052792130

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3205676


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Availability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Gas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tablets", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Laboratory of Cancer Research & Clinical Oncology, University of Antwerp, B-2610, Wilrijk, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Bruijn", 
        "givenName": "E. A.", 
        "id": "sg:person.01351125343.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351125343.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Antonius Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.415960.f", 
          "name": [
            "St. Antonius Ziekenhuis, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slee", 
        "givenName": "P. H. TH. J", 
        "id": "sg:person.01207254777.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207254777.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Laboratory of Cancer Research & Clinical Oncology, University of Antwerp, B-2610, Wilrijk, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Oosterom", 
        "givenName": "A. T.", 
        "id": "sg:person.0653245357.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653245357.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Onze Lieve Vrouwe Gasthuis, 1e Oosterparkstraat 179, 1091, HA Amsterdam, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lameijer", 
        "givenName": "D. W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Onze Lieve Vrouwe Gasthuis, 1e Oosterparkstraat 179, 1091, HA Amsterdam, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roozendaal", 
        "givenName": "K. J.", 
        "id": "sg:person.01277552005.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277552005.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University", 
          "id": "https://www.grid.ac/institutes/grid.5132.5", 
          "name": [
            "Center for Bio-Pharmaceutical Sciences, P.O. Box 9502, 2300, RA Leiden, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tjaden", 
        "givenName": "U. R.", 
        "id": "sg:person.0756716267.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756716267.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jps.2600760103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006817545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9673(01)93663-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013608900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(00)81397-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028394350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(87)90047-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028736892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0163-7258(87)90047-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028736892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00630298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030740537", 
          "https://doi.org/10.1007/bf00630298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00630298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030740537", 
          "https://doi.org/10.1007/bf00630298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1983.tb02302.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034548399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-197904050-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035579485", 
          "https://doi.org/10.2165/00003088-197904050-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000215401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037775884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000215401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037775884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(00)84787-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041813831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198101013040103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044945035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2964(79)90198-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050641219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.1979.tb01004.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053028338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079817374", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079899130", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079935278", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081806815", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081906333", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082123155", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988-10", 
    "datePublishedReg": "1988-10-01", 
    "description": "Cyclophosphamide was administered to 12 breast cancer patients in combination with methotrexate and fluorouracil. Doses prescribed were cyclophosphamide 75 mg/m2, methotrexate 30 mg/m2 and fluorouracil 500 mg/m2 (per square meter body surface). Cyclophosphamide was administered intravenously and orally in aqueous solutions and in tablets in a randomized cross-over trial. Methotrexate and fluorouracil were administered intravenously, methotrexate was given first and then fluorouracil. Assays of cyclophosphamide in blood plasma were performed by capillary gas chromatography. Data of mean bioavailability of cyclophosphamide administered by tablets were suggestive of sufficient absorption. In 2 patients, however, a lower bioavailability of cyclophosphamide was demonstrated. Intra-individual differences in the terminal slope of the plasma decay curves after intravenous and oral administration in some patients decreased the calculated bioavailability of cyclophosphamide, if these values were included in the calculation of cyclophosphamide bioavailability. Compared with the administration of the solutions peak times, lag-times and mean absorption times of cyclophosphamide given in tablets were markedly prolonged. It is concluded that interactions between cyclophosphamide and methotrexate and/or fluorouracil after oral dosing as tablets are different from interactions observed after intravenous administration of cyclosphosphamide.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01956871", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1044817", 
        "issn": [
          "2210-7703", 
          "2210-7711"
        ], 
        "name": "International Journal of Clinical Pharmacy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Pharmacokin\u0117tics of intravenous and oral cyclophosphamide in the presence of methotrexate and fluorouracil", 
    "pagination": "200-206", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fb76f567c4c244274ba041a0a12d8d27367f9edb2739687023b03c0494a92ea6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3205676"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7907992"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01956871"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052792130"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01956871", 
      "https://app.dimensions.ai/details/publication/pub.1052792130"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000355_0000000355/records_53016_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01956871"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01956871'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01956871'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01956871'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01956871'


 

This table displays all metadata directly associated to this object as RDF triples.

218 TRIPLES      21 PREDICATES      61 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01956871 schema:about N1dd79880e02642998659ea2b88f3e7e9
2 N20475276da734f93b2279d4f0ba093a6
3 N36a97945d5e24570b9e9eb1db18495d1
4 N585d9beaf30c4e9480ebca7f57e7aee3
5 N6fb6590cd92a43c6aa483bdc60ae4230
6 N7404e754511448b08a5b5f9b7c6accf8
7 N8c7a8906662e4b58a9f2ed34ecfe2b84
8 N989e43b904a34268adbc873d2232489d
9 N9a0a1e776b4d4fb7b050f259c318d8a4
10 Na241bffc131c41a29faf9939123d8fd0
11 Na4745d11a1c349b19502fa4ff8b402ff
12 Nbedfc9be3ebb4e1eaf622d16a1264e40
13 Ncdeaf39c5d834d34b9af0b99bb943e8f
14 Ndb91d8bc44974ee3b86f8a8a86245e8a
15 anzsrc-for:11
16 anzsrc-for:1115
17 schema:author Nd41cd6321d674df6a15488334b04a827
18 schema:citation sg:pub.10.1007/bf00630298
19 sg:pub.10.2165/00003088-197904050-00004
20 https://app.dimensions.ai/details/publication/pub.1079817374
21 https://app.dimensions.ai/details/publication/pub.1079899130
22 https://app.dimensions.ai/details/publication/pub.1079935278
23 https://app.dimensions.ai/details/publication/pub.1081806815
24 https://app.dimensions.ai/details/publication/pub.1081906333
25 https://app.dimensions.ai/details/publication/pub.1082123155
26 https://doi.org/10.1002/jps.2600760103
27 https://doi.org/10.1016/0014-2964(79)90198-1
28 https://doi.org/10.1016/0163-7258(87)90047-7
29 https://doi.org/10.1016/s0021-9673(01)93663-5
30 https://doi.org/10.1016/s0378-4347(00)81397-3
31 https://doi.org/10.1016/s0378-4347(00)84787-8
32 https://doi.org/10.1056/nejm198101013040103
33 https://doi.org/10.1111/j.1365-2125.1979.tb01004.x
34 https://doi.org/10.1111/j.1365-2125.1983.tb02302.x
35 https://doi.org/10.1159/000215401
36 schema:datePublished 1988-10
37 schema:datePublishedReg 1988-10-01
38 schema:description Cyclophosphamide was administered to 12 breast cancer patients in combination with methotrexate and fluorouracil. Doses prescribed were cyclophosphamide 75 mg/m2, methotrexate 30 mg/m2 and fluorouracil 500 mg/m2 (per square meter body surface). Cyclophosphamide was administered intravenously and orally in aqueous solutions and in tablets in a randomized cross-over trial. Methotrexate and fluorouracil were administered intravenously, methotrexate was given first and then fluorouracil. Assays of cyclophosphamide in blood plasma were performed by capillary gas chromatography. Data of mean bioavailability of cyclophosphamide administered by tablets were suggestive of sufficient absorption. In 2 patients, however, a lower bioavailability of cyclophosphamide was demonstrated. Intra-individual differences in the terminal slope of the plasma decay curves after intravenous and oral administration in some patients decreased the calculated bioavailability of cyclophosphamide, if these values were included in the calculation of cyclophosphamide bioavailability. Compared with the administration of the solutions peak times, lag-times and mean absorption times of cyclophosphamide given in tablets were markedly prolonged. It is concluded that interactions between cyclophosphamide and methotrexate and/or fluorouracil after oral dosing as tablets are different from interactions observed after intravenous administration of cyclosphosphamide.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree false
42 schema:isPartOf N2cbbda6a013f45f796bf0c01a99eeb3b
43 N3efca496508d44d082f5e8bcd950b7c4
44 sg:journal.1044817
45 schema:name Pharmacokinėtics of intravenous and oral cyclophosphamide in the presence of methotrexate and fluorouracil
46 schema:pagination 200-206
47 schema:productId N1fb2c8c31c684685887c43c0313e5536
48 N40f563712c0447a79dd67c1c89c5b812
49 N8d85c27424af495b9ce96d0fb152a0ce
50 Nb758569f6ac14c20b69e12830ad20382
51 Ned446cd3d32445c692e06f59ee6028c4
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052792130
53 https://doi.org/10.1007/bf01956871
54 schema:sdDatePublished 2019-04-11T11:24
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N4117a3900d284b528b22c2a20611d3b5
57 schema:url http://link.springer.com/10.1007/BF01956871
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N1dd79880e02642998659ea2b88f3e7e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Tablets
63 rdf:type schema:DefinedTerm
64 N1e434d4da54f4aab8188514c6bba2713 rdf:first sg:person.01207254777.24
65 rdf:rest N2a9c7eb337874c38b97cf92a4896a9cc
66 N1fb2c8c31c684685887c43c0313e5536 schema:name readcube_id
67 schema:value fb76f567c4c244274ba041a0a12d8d27367f9edb2739687023b03c0494a92ea6
68 rdf:type schema:PropertyValue
69 N20475276da734f93b2279d4f0ba093a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Administration, Oral
71 rdf:type schema:DefinedTerm
72 N27ab0359a3a04ddc8c77b5d117a5c5e4 rdf:first N9a72b2a9269e43ef9ccbccfc3c919003
73 rdf:rest N45711618b1674ac88d38905fd788c1c3
74 N2a9c7eb337874c38b97cf92a4896a9cc rdf:first sg:person.0653245357.14
75 rdf:rest N27ab0359a3a04ddc8c77b5d117a5c5e4
76 N2cbbda6a013f45f796bf0c01a99eeb3b schema:issueNumber 5
77 rdf:type schema:PublicationIssue
78 N36a97945d5e24570b9e9eb1db18495d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Breast Neoplasms
80 rdf:type schema:DefinedTerm
81 N3b79ab9f9a1b4ab99cab642cdb511297 rdf:first sg:person.0756716267.86
82 rdf:rest rdf:nil
83 N3efca496508d44d082f5e8bcd950b7c4 schema:volumeNumber 10
84 rdf:type schema:PublicationVolume
85 N40f563712c0447a79dd67c1c89c5b812 schema:name pubmed_id
86 schema:value 3205676
87 rdf:type schema:PropertyValue
88 N4117a3900d284b528b22c2a20611d3b5 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N45711618b1674ac88d38905fd788c1c3 rdf:first sg:person.01277552005.46
91 rdf:rest N3b79ab9f9a1b4ab99cab642cdb511297
92 N585d9beaf30c4e9480ebca7f57e7aee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Female
94 rdf:type schema:DefinedTerm
95 N6fb6590cd92a43c6aa483bdc60ae4230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Methotrexate
97 rdf:type schema:DefinedTerm
98 N7404e754511448b08a5b5f9b7c6accf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Injections, Intravenous
100 rdf:type schema:DefinedTerm
101 N8c7a8906662e4b58a9f2ed34ecfe2b84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Antineoplastic Combined Chemotherapy Protocols
103 rdf:type schema:DefinedTerm
104 N8d85c27424af495b9ce96d0fb152a0ce schema:name nlm_unique_id
105 schema:value 7907992
106 rdf:type schema:PropertyValue
107 N989e43b904a34268adbc873d2232489d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Middle Aged
109 rdf:type schema:DefinedTerm
110 N9a0a1e776b4d4fb7b050f259c318d8a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Cyclophosphamide
112 rdf:type schema:DefinedTerm
113 N9a72b2a9269e43ef9ccbccfc3c919003 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
114 schema:familyName Lameijer
115 schema:givenName D. W.
116 rdf:type schema:Person
117 Na241bffc131c41a29faf9939123d8fd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Biological Availability
119 rdf:type schema:DefinedTerm
120 Na4745d11a1c349b19502fa4ff8b402ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Adult
122 rdf:type schema:DefinedTerm
123 Nb758569f6ac14c20b69e12830ad20382 schema:name dimensions_id
124 schema:value pub.1052792130
125 rdf:type schema:PropertyValue
126 Nbedfc9be3ebb4e1eaf622d16a1264e40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 Ncdeaf39c5d834d34b9af0b99bb943e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Chromatography, Gas
131 rdf:type schema:DefinedTerm
132 Nd41cd6321d674df6a15488334b04a827 rdf:first sg:person.01351125343.11
133 rdf:rest N1e434d4da54f4aab8188514c6bba2713
134 Ndb91d8bc44974ee3b86f8a8a86245e8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Fluorouracil
136 rdf:type schema:DefinedTerm
137 Ned446cd3d32445c692e06f59ee6028c4 schema:name doi
138 schema:value 10.1007/bf01956871
139 rdf:type schema:PropertyValue
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
144 schema:name Pharmacology and Pharmaceutical Sciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1044817 schema:issn 2210-7703
147 2210-7711
148 schema:name International Journal of Clinical Pharmacy
149 rdf:type schema:Periodical
150 sg:person.01207254777.24 schema:affiliation https://www.grid.ac/institutes/grid.415960.f
151 schema:familyName Slee
152 schema:givenName P. H. TH. J
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207254777.24
154 rdf:type schema:Person
155 sg:person.01277552005.46 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
156 schema:familyName Roozendaal
157 schema:givenName K. J.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277552005.46
159 rdf:type schema:Person
160 sg:person.01351125343.11 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
161 schema:familyName De Bruijn
162 schema:givenName E. A.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351125343.11
164 rdf:type schema:Person
165 sg:person.0653245357.14 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
166 schema:familyName Van Oosterom
167 schema:givenName A. T.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653245357.14
169 rdf:type schema:Person
170 sg:person.0756716267.86 schema:affiliation https://www.grid.ac/institutes/grid.5132.5
171 schema:familyName Tjaden
172 schema:givenName U. R.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756716267.86
174 rdf:type schema:Person
175 sg:pub.10.1007/bf00630298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030740537
176 https://doi.org/10.1007/bf00630298
177 rdf:type schema:CreativeWork
178 sg:pub.10.2165/00003088-197904050-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035579485
179 https://doi.org/10.2165/00003088-197904050-00004
180 rdf:type schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1079817374 schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1079899130 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1079935278 schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1081806815 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1081906333 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1082123155 schema:CreativeWork
187 https://doi.org/10.1002/jps.2600760103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006817545
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0014-2964(79)90198-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050641219
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0163-7258(87)90047-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028736892
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0021-9673(01)93663-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013608900
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0378-4347(00)81397-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028394350
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0378-4347(00)84787-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041813831
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1056/nejm198101013040103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044945035
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1111/j.1365-2125.1979.tb01004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053028338
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/j.1365-2125.1983.tb02302.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034548399
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1159/000215401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037775884
206 rdf:type schema:CreativeWork
207 https://www.grid.ac/institutes/grid.415960.f schema:alternateName St. Antonius Ziekenhuis
208 schema:name St. Antonius Ziekenhuis, P.O. Box 2500, 3430, EM Nieuwegein, the Netherlands
209 rdf:type schema:Organization
210 https://www.grid.ac/institutes/grid.440209.b schema:alternateName Onze Lieve Vrouwe Gasthuis
211 schema:name Onze Lieve Vrouwe Gasthuis, 1e Oosterparkstraat 179, 1091, HA Amsterdam, the Netherlands
212 rdf:type schema:Organization
213 https://www.grid.ac/institutes/grid.5132.5 schema:alternateName Leiden University
214 schema:name Center for Bio-Pharmaceutical Sciences, P.O. Box 9502, 2300, RA Leiden, the Netherlands
215 rdf:type schema:Organization
216 https://www.grid.ac/institutes/grid.5284.b schema:alternateName University of Antwerp
217 schema:name Laboratory of Cancer Research & Clinical Oncology, University of Antwerp, B-2610, Wilrijk, Belgium
218 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...