The accuracy of aminoacylation — ensuring the fidelity of the genetic code View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

D. Söll

ABSTRACT

The fidelity of protein biosynthesis rests not only on the proper interaction of the messenger RNA codon with the anticodon of the tRNA, but also on the correct attachment of amino acids to their corresponding (cognate) transfer RNA (tRNA) species. This process is catalyzed by the aminoacyl-tRNA synthetases which discriminate with remarkable selectivity amongst many structurally similar tRNAs. The basis for this highly specific recognition of tRNA by these enzymes (also referred to as 'tRNA identity') is currently being elucidated by genetic, biochemical and biophysical techniques. At least two factors are important in determining the accuracy of aminoacylation: a) 'identity elements' in tRNA denote nucleotides in certain positions crucial for protein interactions determining specificity, and b) the occurrence in vivo of competition between synthetases for a particular tRNA which may have ambiguous identity. More... »

PAGES

1089-1096

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01936918

DOI

http://dx.doi.org/10.1007/bf01936918

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001145980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2253707


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