Experimental liver fibrosis induced in rats receiving high doses of alcohol and alternating between regular and vitamin-depleted diets View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-07

AUTHORS

H. Hirano, T. Hirano, K. Hirata, M. Tamura, T. Yamaura, T. Hamada

ABSTRACT

Liver fibrosis was induced in rats by simulating human alcoholic eating and drinking patterns. Alcohol addiction was established by gradually increasing the ethanol concentration in the drinking water; salts were added at the terminal stage. The hepatocytes of rats receiving alcohol concentrations exceeding 50% (v/v) (similar to vodka) exhibited alcoholic hyaline (Mallory bodies). Alcoholic liver fibrosis was induced by alternating between regular and autoclaved (vitamin-depleted) diets, simulating the irregular eating habits of human alcoholics. In the livers of rats receiving 70% (v/v) ethanol (comparable to absinthe) with 25% saline and fed the alternating diets, pericellular fibrosis was induced. No significant difference in calorie intake between control and alcohol rats was detected except when rats underwent drinking bouts (heavy drinking phase). This indicates that neither a high-fat diet nor a choline-depleted diet is necessary to induce the alcoholic fibrosis seen in human alcoholics. More... »

PAGES

710-715

References to SciGraph publications

  • 1991-02. Retinol-induced modification of the extracellular matrix of endothelial cells: Its role in growth control in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 1977-12. Three centuries of alcohol in the British diet in NATURE
  • 1989-06. Absinthe. in SCIENTIFIC AMERICAN
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01925580

    DOI

    http://dx.doi.org/10.1007/bf01925580

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018948108

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8698115


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