Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-07

AUTHORS

S. C. Schmidt-Ott, C. Bletz, C. Vahl, W. Saggau, S. Hagl, J. C. Rüegg

ABSTRACT

During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 μM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40–50% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 μM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this “energy sparing” effect is probably offset by the greater “tension cost” that decreases the “efficiency” of tension maintenance in the presence of inorganic phosphate. More... »

PAGES

358-366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01907128

DOI

http://dx.doi.org/10.1007/bf01907128

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038393401

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2146947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histological Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myofibrils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osmolar Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphates", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt-Ott", 
        "givenName": "S. C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bletz", 
        "givenName": "C.", 
        "id": "sg:person.0715766577.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715766577.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vahl", 
        "givenName": "C.", 
        "id": "sg:person.010027231764.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027231764.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saggau", 
        "givenName": "W.", 
        "id": "sg:person.015566503424.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015566503424.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagl", 
        "givenName": "S.", 
        "id": "sg:person.01172065265.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172065265.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00fcegg", 
        "givenName": "J. C.", 
        "id": "sg:person.01253410563.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253410563.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02137732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024957277", 
          "https://doi.org/10.1007/bf02137732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00587716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007812612", 
          "https://doi.org/10.1007/bf00587716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-46352-5_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044468453", 
          "https://doi.org/10.1007/978-3-642-46352-5_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00592176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030186839", 
          "https://doi.org/10.1007/bf00592176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00370594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026877089", 
          "https://doi.org/10.1007/bf00370594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01906351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030389790", 
          "https://doi.org/10.1007/bf01906351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00657515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019167793", 
          "https://doi.org/10.1007/bf00657515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009874415", 
          "https://doi.org/10.1007/bf00585629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00581833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042463039", 
          "https://doi.org/10.1007/bf00581833"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-07", 
    "datePublishedReg": "1990-07-01", 
    "description": "During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 \u03bcM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40\u201350% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 \u03bcM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this \u201cenergy sparing\u201d effect is probably offset by the greater \u201ctension cost\u201d that decreases the \u201cefficiency\u201d of tension maintenance in the presence of inorganic phosphate.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01907128", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016443", 
        "issn": [
          "0300-8428", 
          "1435-1803"
        ], 
        "name": "Basic Research in Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "85"
      }
    ], 
    "keywords": [
      "contractile force", 
      "calcium-force relationship", 
      "myofibrillar ATPase", 
      "calcium sensitivity", 
      "tension cost", 
      "maximal calcium activation", 
      "calcium activation", 
      "heart failure", 
      "hypoxic myocardium", 
      "human myocardium", 
      "atrial fibers", 
      "Mg-ATP concentration", 
      "inhibitory effect", 
      "force development", 
      "effect of Pi", 
      "myocardium", 
      "energy sparing", 
      "Mg-ATP", 
      "reduced levels", 
      "ATPase activity", 
      "force production", 
      "inorganic phosphate", 
      "tension maintenance", 
      "crossbridge kinetics", 
      "activation", 
      "calcium affinity", 
      "contractility", 
      "sparing", 
      "troponin", 
      "low concentrations", 
      "ATPase", 
      "effect", 
      "activity", 
      "inhibition", 
      "sensitivity", 
      "concentration", 
      "contrast", 
      "failure", 
      "findings", 
      "PI", 
      "levels", 
      "fibers", 
      "phosphate", 
      "maintenance", 
      "presence", 
      "affinity", 
      "development", 
      "relationship", 
      "ratio", 
      "production", 
      "cost", 
      "values", 
      "conditions", 
      "force", 
      "kinetics", 
      "efficiency", 
      "hypoxic heart failure", 
      "foree inhibition", 
      "submaximal calcium activation"
    ], 
    "name": "Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium", 
    "pagination": "358-366", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038393401"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01907128"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2146947"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01907128", 
      "https://app.dimensions.ai/details/publication/pub.1038393401"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_236.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01907128"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      22 PREDICATES      105 URIs      88 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01907128 schema:about N0deaeef2240d4bb3b24dc79ac6c1872b
2 N17bccb0dc7ff49368cb3ae385f5bc2c6
3 N1f37f9cd979746fabf40641fe2debd76
4 N272942795c7f43fa878555d9d423a11e
5 N4764fbe9b06342eb88ba4b94996a2e3b
6 N60e207efd0d7458985614fec6eb6915a
7 N73376dd272d94b8f86ec1a7a0495553c
8 N98e114255838489a86b57ad7158f0a88
9 Na55464c490ee416f8a10ff5a05f99d9e
10 Nb36a212a5c8a4a5484c7f4ea0481f377
11 anzsrc-for:11
12 anzsrc-for:1116
13 schema:author Ndcea0f364d734eaf84abd6f283d812f2
14 schema:citation sg:pub.10.1007/978-3-642-46352-5_5
15 sg:pub.10.1007/bf00370594
16 sg:pub.10.1007/bf00581833
17 sg:pub.10.1007/bf00585629
18 sg:pub.10.1007/bf00587716
19 sg:pub.10.1007/bf00592176
20 sg:pub.10.1007/bf00657515
21 sg:pub.10.1007/bf01906351
22 sg:pub.10.1007/bf02137732
23 schema:datePublished 1990-07
24 schema:datePublishedReg 1990-07-01
25 schema:description During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 μM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40–50% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 μM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this “energy sparing” effect is probably offset by the greater “tension cost” that decreases the “efficiency” of tension maintenance in the presence of inorganic phosphate.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N64c590068dff4c11b8c93b9d5b9a4c0f
30 Nac11e509c55c423587882d0b72e2975f
31 sg:journal.1016443
32 schema:keywords ATPase
33 ATPase activity
34 Mg-ATP
35 Mg-ATP concentration
36 PI
37 activation
38 activity
39 affinity
40 atrial fibers
41 calcium activation
42 calcium affinity
43 calcium sensitivity
44 calcium-force relationship
45 concentration
46 conditions
47 contractile force
48 contractility
49 contrast
50 cost
51 crossbridge kinetics
52 development
53 effect
54 effect of Pi
55 efficiency
56 energy sparing
57 failure
58 fibers
59 findings
60 force
61 force development
62 force production
63 foree inhibition
64 heart failure
65 human myocardium
66 hypoxic heart failure
67 hypoxic myocardium
68 inhibition
69 inhibitory effect
70 inorganic phosphate
71 kinetics
72 levels
73 low concentrations
74 maintenance
75 maximal calcium activation
76 myocardium
77 myofibrillar ATPase
78 phosphate
79 presence
80 production
81 ratio
82 reduced levels
83 relationship
84 sensitivity
85 sparing
86 submaximal calcium activation
87 tension cost
88 tension maintenance
89 troponin
90 values
91 schema:name Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium
92 schema:pagination 358-366
93 schema:productId N586bbcbab7af49359074987d4f349568
94 N7eb1f2df22a14fee86e234a80728fcec
95 Ned662f53e5174dcebf9550c3b4cb9724
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038393401
97 https://doi.org/10.1007/bf01907128
98 schema:sdDatePublished 2022-01-01T18:06
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher Ncbb6dd91b952452f9978ef1e85698041
101 schema:url https://doi.org/10.1007/bf01907128
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N0deaeef2240d4bb3b24dc79ac6c1872b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Myofibrils
107 rdf:type schema:DefinedTerm
108 N17bccb0dc7ff49368cb3ae385f5bc2c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adenosine Triphosphatases
110 rdf:type schema:DefinedTerm
111 N1f37f9cd979746fabf40641fe2debd76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Phosphates
113 rdf:type schema:DefinedTerm
114 N272942795c7f43fa878555d9d423a11e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Histological Techniques
116 rdf:type schema:DefinedTerm
117 N4764fbe9b06342eb88ba4b94996a2e3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Myocardium
119 rdf:type schema:DefinedTerm
120 N586bbcbab7af49359074987d4f349568 schema:name pubmed_id
121 schema:value 2146947
122 rdf:type schema:PropertyValue
123 N60e207efd0d7458985614fec6eb6915a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Calcium
125 rdf:type schema:DefinedTerm
126 N64c590068dff4c11b8c93b9d5b9a4c0f schema:issueNumber 4
127 rdf:type schema:PublicationIssue
128 N6a90392335fc4df8984501f6f967f8dc rdf:first sg:person.0715766577.74
129 rdf:rest Ne43947e6fcb04e66afafadb2b6edad5c
130 N73376dd272d94b8f86ec1a7a0495553c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N7eb1f2df22a14fee86e234a80728fcec schema:name doi
134 schema:value 10.1007/bf01907128
135 rdf:type schema:PropertyValue
136 N98e114255838489a86b57ad7158f0a88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Myocardial Contraction
138 rdf:type schema:DefinedTerm
139 Na55464c490ee416f8a10ff5a05f99d9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adenosine Triphosphate
141 rdf:type schema:DefinedTerm
142 Nac11e509c55c423587882d0b72e2975f schema:volumeNumber 85
143 rdf:type schema:PublicationVolume
144 Nb36a212a5c8a4a5484c7f4ea0481f377 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Osmolar Concentration
146 rdf:type schema:DefinedTerm
147 Ncbb6dd91b952452f9978ef1e85698041 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 Nd55cfbe6a71c46a39f44160c514ba14f rdf:first sg:person.01253410563.36
150 rdf:rest rdf:nil
151 Nd6fab1ea89af4df6acb3a7e449fcf00b rdf:first sg:person.015566503424.19
152 rdf:rest Nfbabc3682eab4c3396b43de532643a68
153 Ndcea0f364d734eaf84abd6f283d812f2 rdf:first Nf6781775c9e54c34a0b172cae45eade7
154 rdf:rest N6a90392335fc4df8984501f6f967f8dc
155 Ne43947e6fcb04e66afafadb2b6edad5c rdf:first sg:person.010027231764.34
156 rdf:rest Nd6fab1ea89af4df6acb3a7e449fcf00b
157 Ned662f53e5174dcebf9550c3b4cb9724 schema:name dimensions_id
158 schema:value pub.1038393401
159 rdf:type schema:PropertyValue
160 Nf6781775c9e54c34a0b172cae45eade7 schema:affiliation grid-institutes:grid.7700.0
161 schema:familyName Schmidt-Ott
162 schema:givenName S. C.
163 rdf:type schema:Person
164 Nfbabc3682eab4c3396b43de532643a68 rdf:first sg:person.01172065265.77
165 rdf:rest Nd55cfbe6a71c46a39f44160c514ba14f
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
170 schema:name Medical Physiology
171 rdf:type schema:DefinedTerm
172 sg:journal.1016443 schema:issn 0300-8428
173 1435-1803
174 schema:name Basic Research in Cardiology
175 schema:publisher Springer Nature
176 rdf:type schema:Periodical
177 sg:person.010027231764.34 schema:affiliation grid-institutes:None
178 schema:familyName Vahl
179 schema:givenName C.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027231764.34
181 rdf:type schema:Person
182 sg:person.01172065265.77 schema:affiliation grid-institutes:None
183 schema:familyName Hagl
184 schema:givenName S.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172065265.77
186 rdf:type schema:Person
187 sg:person.01253410563.36 schema:affiliation grid-institutes:grid.7700.0
188 schema:familyName Rüegg
189 schema:givenName J. C.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253410563.36
191 rdf:type schema:Person
192 sg:person.015566503424.19 schema:affiliation grid-institutes:None
193 schema:familyName Saggau
194 schema:givenName W.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015566503424.19
196 rdf:type schema:Person
197 sg:person.0715766577.74 schema:affiliation grid-institutes:grid.7700.0
198 schema:familyName Bletz
199 schema:givenName C.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715766577.74
201 rdf:type schema:Person
202 sg:pub.10.1007/978-3-642-46352-5_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044468453
203 https://doi.org/10.1007/978-3-642-46352-5_5
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00370594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026877089
206 https://doi.org/10.1007/bf00370594
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf00581833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042463039
209 https://doi.org/10.1007/bf00581833
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/bf00585629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009874415
212 https://doi.org/10.1007/bf00585629
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/bf00587716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007812612
215 https://doi.org/10.1007/bf00587716
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf00592176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030186839
218 https://doi.org/10.1007/bf00592176
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf00657515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019167793
221 https://doi.org/10.1007/bf00657515
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf01906351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030389790
224 https://doi.org/10.1007/bf01906351
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/bf02137732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024957277
227 https://doi.org/10.1007/bf02137732
228 rdf:type schema:CreativeWork
229 grid-institutes:None schema:alternateName Department of Cardiac Surgery, University of Heidelberg, FRG
230 schema:name Department of Cardiac Surgery, University of Heidelberg, FRG
231 rdf:type schema:Organization
232 grid-institutes:grid.7700.0 schema:alternateName Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG
233 schema:name Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...