Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-07

AUTHORS

S. C. Schmidt-Ott, C. Bletz, C. Vahl, W. Saggau, S. Hagl, J. C. Rüegg

ABSTRACT

During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 μM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40–50% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 μM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this “energy sparing” effect is probably offset by the greater “tension cost” that decreases the “efficiency” of tension maintenance in the presence of inorganic phosphate. More... »

PAGES

358-366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01907128

DOI

http://dx.doi.org/10.1007/bf01907128

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038393401

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2146947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histological Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myofibrils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osmolar Concentration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphates", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt-Ott", 
        "givenName": "S. C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bletz", 
        "givenName": "C.", 
        "id": "sg:person.0715766577.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715766577.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vahl", 
        "givenName": "C.", 
        "id": "sg:person.010027231764.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027231764.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saggau", 
        "givenName": "W.", 
        "id": "sg:person.015566503424.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015566503424.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiac Surgery, University of Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiac Surgery, University of Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagl", 
        "givenName": "S.", 
        "id": "sg:person.01172065265.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172065265.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00fcegg", 
        "givenName": "J. C.", 
        "id": "sg:person.01253410563.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253410563.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00370594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026877089", 
          "https://doi.org/10.1007/bf00370594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02137732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024957277", 
          "https://doi.org/10.1007/bf02137732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01906351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030389790", 
          "https://doi.org/10.1007/bf01906351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00587716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007812612", 
          "https://doi.org/10.1007/bf00587716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00657515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019167793", 
          "https://doi.org/10.1007/bf00657515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00592176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030186839", 
          "https://doi.org/10.1007/bf00592176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00581833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042463039", 
          "https://doi.org/10.1007/bf00581833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-46352-5_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044468453", 
          "https://doi.org/10.1007/978-3-642-46352-5_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00585629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009874415", 
          "https://doi.org/10.1007/bf00585629"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-07", 
    "datePublishedReg": "1990-07-01", 
    "description": "During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 \u03bcM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40\u201350% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 \u03bcM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this \u201cenergy sparing\u201d effect is probably offset by the greater \u201ctension cost\u201d that decreases the \u201cefficiency\u201d of tension maintenance in the presence of inorganic phosphate.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01907128", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016443", 
        "issn": [
          "0300-8428", 
          "1435-1803"
        ], 
        "name": "Basic Research in Cardiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "85"
      }
    ], 
    "keywords": [
      "contractile force", 
      "myofibrillar ATPase", 
      "calcium-force relationship", 
      "calcium sensitivity", 
      "tension cost", 
      "calcium activation", 
      "heart failure", 
      "hypoxic myocardium", 
      "maximal calcium activation", 
      "atrial fibers", 
      "human myocardium", 
      "inhibitory effect", 
      "ATPase activity", 
      "effect of Pi", 
      "myocardium", 
      "force development", 
      "reduced levels", 
      "inorganic phosphate", 
      "energy sparing", 
      "Mg-ATP concentration", 
      "force production", 
      "tension maintenance", 
      "Mg-ATP", 
      "crossbridge kinetics", 
      "activation", 
      "ATPase", 
      "contractility", 
      "sparing", 
      "low concentrations", 
      "troponin", 
      "calcium affinity", 
      "activity", 
      "effect", 
      "inhibition", 
      "concentration", 
      "sensitivity", 
      "contrast", 
      "failure", 
      "PI", 
      "findings", 
      "levels", 
      "phosphate", 
      "fibers", 
      "maintenance", 
      "presence", 
      "affinity", 
      "development", 
      "relationship", 
      "ratio", 
      "production", 
      "cost", 
      "values", 
      "conditions", 
      "kinetics", 
      "force", 
      "efficiency"
    ], 
    "name": "Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium", 
    "pagination": "358-366", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038393401"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01907128"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2146947"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01907128", 
      "https://app.dimensions.ai/details/publication/pub.1038393401"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_248.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01907128"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01907128'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      22 PREDICATES      102 URIs      85 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01907128 schema:about N3405bdb82e9f455fb59e118c957c68cf
2 N4f7a5b44169049b494a0b1e898dffa53
3 N55cc638f54584f50b149e0b5ce6842f6
4 N5e7483544b1648ec93cef92115103892
5 N64560e77c1bf4c889bbf208fe6f66f27
6 N6f194b4aa9d4472fa5dbf6db6e636e2b
7 N7396d6d6ab7f4a6b99a4f2a267afa7aa
8 Nb8f8bca137884a36ac423fd5135a0f1c
9 Nc1f960059bae4cf8af6de426273918a6
10 Ne5a0012717da438db2e7eaed87bc66dc
11 anzsrc-for:11
12 anzsrc-for:1116
13 schema:author N7d89a6d0e9d14744a40a463fbd220ce0
14 schema:citation sg:pub.10.1007/978-3-642-46352-5_5
15 sg:pub.10.1007/bf00370594
16 sg:pub.10.1007/bf00581833
17 sg:pub.10.1007/bf00585629
18 sg:pub.10.1007/bf00587716
19 sg:pub.10.1007/bf00592176
20 sg:pub.10.1007/bf00657515
21 sg:pub.10.1007/bf01906351
22 sg:pub.10.1007/bf02137732
23 schema:datePublished 1990-07
24 schema:datePublishedReg 1990-07-01
25 schema:description During hypoxic heart failure, inorganic phosphate (Pi) accumulates. We report the effects of Pi on force development and on myofibrillar ATPase-activity of human skinned atrial fibers, both at normal and at reduced levels of Mg-ATP. Pi (10 mM) depressed force production at maximal calcium activation (pCa 4.3) by about 40%. At higher pCa values (pCa 5.6), foree inhibition was even more pronounced, but at low concentrations of Mg-ATP (10 μM), Pi was less effective. In contrast to contractile force, myofibrillar ATPase was only inhibited by about 10% at pCa 4.3, whereas it could be inhibited by 40–50% at submaximal calcium activation (pCa 5.6). As Pi inhibited contractile force more than ATPase activity, the ratio of ATPase-activity to foree (tension cost) was increased by inorganic phosphate. ATPase-activity and tension cost were significantly reduced by loweing Mg-ATP concentration to 10 μM, whereas contractile force was less affected. Pi did not affect ATPase under these conditions at 10 mM Mg-ATP. Pi also shifted the calcium-force relationship towards higher Ca++ concentrations, that is, it decreased calcium sensitivity. In contrast, the calcium sensitivity of myofibrillar ATPase was less affected. These findings suggest that inorganic phosphate may affect the myocardium by altering crossbridge kinetics rather than the calcium affinity of troponin-C. Because of its inhibitory effect on myofibrillar ATPase, inorganic phosphate may be partly cardioprotective in the hypoxic myocardium. However, this “energy sparing” effect is probably offset by the greater “tension cost” that decreases the “efficiency” of tension maintenance in the presence of inorganic phosphate.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N25185d493e014cc6b6fe4e6f4362af23
30 Ncd8d79cfdbab4240a66ae87f70a3836a
31 sg:journal.1016443
32 schema:keywords ATPase
33 ATPase activity
34 Mg-ATP
35 Mg-ATP concentration
36 PI
37 activation
38 activity
39 affinity
40 atrial fibers
41 calcium activation
42 calcium affinity
43 calcium sensitivity
44 calcium-force relationship
45 concentration
46 conditions
47 contractile force
48 contractility
49 contrast
50 cost
51 crossbridge kinetics
52 development
53 effect
54 effect of Pi
55 efficiency
56 energy sparing
57 failure
58 fibers
59 findings
60 force
61 force development
62 force production
63 heart failure
64 human myocardium
65 hypoxic myocardium
66 inhibition
67 inhibitory effect
68 inorganic phosphate
69 kinetics
70 levels
71 low concentrations
72 maintenance
73 maximal calcium activation
74 myocardium
75 myofibrillar ATPase
76 phosphate
77 presence
78 production
79 ratio
80 reduced levels
81 relationship
82 sensitivity
83 sparing
84 tension cost
85 tension maintenance
86 troponin
87 values
88 schema:name Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium
89 schema:pagination 358-366
90 schema:productId N1e4e7479ca50497facffe460c4120186
91 N9a4e92e2ac834924b7690bbecab32e1b
92 Naa811c71523440dba47996dc325eed86
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038393401
94 https://doi.org/10.1007/bf01907128
95 schema:sdDatePublished 2022-05-20T07:19
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N8394edd874824f5c92d3298b3bff0fa0
98 schema:url https://doi.org/10.1007/bf01907128
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N1e4e7479ca50497facffe460c4120186 schema:name dimensions_id
103 schema:value pub.1038393401
104 rdf:type schema:PropertyValue
105 N25185d493e014cc6b6fe4e6f4362af23 schema:issueNumber 4
106 rdf:type schema:PublicationIssue
107 N33aa5ccb915a478d982ae2326f611704 rdf:first sg:person.0715766577.74
108 rdf:rest Nf726b273645644f4858e55e7cc3f2928
109 N3405bdb82e9f455fb59e118c957c68cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Phosphates
111 rdf:type schema:DefinedTerm
112 N4f7a5b44169049b494a0b1e898dffa53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Myocardium
114 rdf:type schema:DefinedTerm
115 N55cc638f54584f50b149e0b5ce6842f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adenosine Triphosphatases
117 rdf:type schema:DefinedTerm
118 N5e7483544b1648ec93cef92115103892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Histological Techniques
120 rdf:type schema:DefinedTerm
121 N64560e77c1bf4c889bbf208fe6f66f27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Osmolar Concentration
123 rdf:type schema:DefinedTerm
124 N6f194b4aa9d4472fa5dbf6db6e636e2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Myofibrils
126 rdf:type schema:DefinedTerm
127 N7396d6d6ab7f4a6b99a4f2a267afa7aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Myocardial Contraction
129 rdf:type schema:DefinedTerm
130 N7d89a6d0e9d14744a40a463fbd220ce0 rdf:first Nd2ba457bd7bb46ba937c893829079d2b
131 rdf:rest N33aa5ccb915a478d982ae2326f611704
132 N8394edd874824f5c92d3298b3bff0fa0 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N9a4e92e2ac834924b7690bbecab32e1b schema:name pubmed_id
135 schema:value 2146947
136 rdf:type schema:PropertyValue
137 Naa811c71523440dba47996dc325eed86 schema:name doi
138 schema:value 10.1007/bf01907128
139 rdf:type schema:PropertyValue
140 Nb8f8bca137884a36ac423fd5135a0f1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adenosine Triphosphate
142 rdf:type schema:DefinedTerm
143 Nc1f960059bae4cf8af6de426273918a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Calcium
145 rdf:type schema:DefinedTerm
146 Nc56c31e769244e76aebf19dadd4a0bb2 rdf:first sg:person.015566503424.19
147 rdf:rest Ne4cb7e7f830c4d659984ecb9e5c6b4b7
148 Ncd8d79cfdbab4240a66ae87f70a3836a schema:volumeNumber 85
149 rdf:type schema:PublicationVolume
150 Nd2ba457bd7bb46ba937c893829079d2b schema:affiliation grid-institutes:grid.7700.0
151 schema:familyName Schmidt-Ott
152 schema:givenName S. C.
153 rdf:type schema:Person
154 Nd539dd0d9347449ba9ca496a2db944c6 rdf:first sg:person.01253410563.36
155 rdf:rest rdf:nil
156 Ne4cb7e7f830c4d659984ecb9e5c6b4b7 rdf:first sg:person.01172065265.77
157 rdf:rest Nd539dd0d9347449ba9ca496a2db944c6
158 Ne5a0012717da438db2e7eaed87bc66dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Humans
160 rdf:type schema:DefinedTerm
161 Nf726b273645644f4858e55e7cc3f2928 rdf:first sg:person.010027231764.34
162 rdf:rest Nc56c31e769244e76aebf19dadd4a0bb2
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical Physiology
168 rdf:type schema:DefinedTerm
169 sg:journal.1016443 schema:issn 0300-8428
170 1435-1803
171 schema:name Basic Research in Cardiology
172 schema:publisher Springer Nature
173 rdf:type schema:Periodical
174 sg:person.010027231764.34 schema:affiliation grid-institutes:None
175 schema:familyName Vahl
176 schema:givenName C.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010027231764.34
178 rdf:type schema:Person
179 sg:person.01172065265.77 schema:affiliation grid-institutes:None
180 schema:familyName Hagl
181 schema:givenName S.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172065265.77
183 rdf:type schema:Person
184 sg:person.01253410563.36 schema:affiliation grid-institutes:grid.7700.0
185 schema:familyName Rüegg
186 schema:givenName J. C.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253410563.36
188 rdf:type schema:Person
189 sg:person.015566503424.19 schema:affiliation grid-institutes:None
190 schema:familyName Saggau
191 schema:givenName W.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015566503424.19
193 rdf:type schema:Person
194 sg:person.0715766577.74 schema:affiliation grid-institutes:grid.7700.0
195 schema:familyName Bletz
196 schema:givenName C.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715766577.74
198 rdf:type schema:Person
199 sg:pub.10.1007/978-3-642-46352-5_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044468453
200 https://doi.org/10.1007/978-3-642-46352-5_5
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf00370594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026877089
203 https://doi.org/10.1007/bf00370594
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00581833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042463039
206 https://doi.org/10.1007/bf00581833
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf00585629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009874415
209 https://doi.org/10.1007/bf00585629
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/bf00587716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007812612
212 https://doi.org/10.1007/bf00587716
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/bf00592176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030186839
215 https://doi.org/10.1007/bf00592176
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf00657515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019167793
218 https://doi.org/10.1007/bf00657515
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf01906351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030389790
221 https://doi.org/10.1007/bf01906351
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf02137732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024957277
224 https://doi.org/10.1007/bf02137732
225 rdf:type schema:CreativeWork
226 grid-institutes:None schema:alternateName Department of Cardiac Surgery, University of Heidelberg, FRG
227 schema:name Department of Cardiac Surgery, University of Heidelberg, FRG
228 rdf:type schema:Organization
229 grid-institutes:grid.7700.0 schema:alternateName Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG
230 schema:name Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, 6900, Heidelberg, FRG
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...