Gene mapping of human bilirubin UDP-glucuronosyl transferase on 1q21-q23 by a cell sorter andin situ hybridization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-06

AUTHORS

Hisashi Hagiwara, Kaoru Takeda, Hiroyuki Ikeda, Hiroshi Nakai, Brian Burchel

ABSTRACT

The human liver bilirubin UDP-glucuronosyl transferase (bilirubin UDPGT) [EC 2.4.1.17] is responsible for the enzyme deficiency in Crigler-Najjar syndrome and/or Gilbert's syndrome. The UDPGT, former shows severe jaundice resulted from a complete absence of bilirubin while the latter has a mild manifestation due to a reduction of the enzyme activity. The gene locus of bilirubin UDPGT was mapped to chromosome 1 by spot-blot hybridization using a cell-sorter, and its regional locus was assigned to 1q21-q23 by high resolution in situ hybridization. More... »

PAGES

189-194

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01876583

DOI

http://dx.doi.org/10.1007/bf01876583

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044618732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1920916


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