Single-channel analysis of a potassium inward rectifier in myocytes of newborn rat heart View Full Text


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Article Info

DATE

1985-06

AUTHORS

M. D. Payet, E. Rousseau, R. Sauvé

ABSTRACT

Unitary K+ currents in single cells isolated from ventricular muscle of newborn rat hearts were measured in response to different potentials and [K]o. TheI/V curves were linear for potentials more negative than the zero-current voltage: especially in high [K]o (150nm KCl), no clear outward currents could be detected indicating a drastic rectification in the inward direction. The channel is mainly selective to K+ but Na+ ions are also carried (PNa/PK=0.056). The channel conductance is proportional to the square root of [K]o but Na+ ions seem to have a facilitatory effect on γK, the single-channel conductance. The channel activity, measured asPo, i.e. the probability to find the channel in open state, decreased as the membrane was hyperpolarized. This behavior was tentatively explained by an inactivation process as the membrane becomes more negative. The rate constants of the transitions between the different states were calculated according to a C−O−C model. A control of the gating process by permeant ion K+ was postulated, based on the increase of one of the rate constants from the closed to the open state with [K]o. Finally, the macroscopicI/V curves calculated fromPo and δi, the unit current, were found to be characteristic of a ion-blocked inward rectifier. More... »

PAGES

79-88

References to SciGraph publications

  • 1978-07. The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1982-03. The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism in EUROPEAN BIOPHYSICS JOURNAL
  • 1982-12. The automated analysis of data from single ionic channels in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1974-12. The anomalous rectification and cation selectivity of the membrane of a starfish egg cell in THE JOURNAL OF MEMBRANE BIOLOGY
  • 1983-04. Voltage and Ca2+-activated K+ channel in baso-lateral acinar cell membranes of mammalian salivary glands in NATURE
  • 1982-07. External K+ ions increase rate of opening of outward current channels in snail neurons in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1983-11. Properties of an inward rectifying K channel in the membrane of guinea-pig atrial cardioballs in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1983-05. Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart in NATURE
  • 1981-10. Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture in NATURE
  • 1981-06. K+ channels close more slowly in the presence of external K+ and Rb+ in NATURE
  • 1980-07. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist in NATURE
  • 1981-08. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1981-11. Single channel potassium currents of the anomalous rectifier in NATURE
  • 1983-02. Single channel K+ currents from HeLa cells in THE JOURNAL OF MEMBRANE BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01870774

    DOI

    http://dx.doi.org/10.1007/bf01870774

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035031963

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2411932


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