Electrical activity and metabolism in cardiac tissue: An experimental and theoretical study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-12

AUTHORS

H. G. Haas, R. Kern, H. M. Einwächter

ABSTRACT

Summary(1) Effects of the metabolic inhibitor 2,4-dinitrophenol (DNP) on electrical activity in frog atria were studied by means of the sucrose-gap technique and in tracer experiments. (2) Voltage-clamp studies of ionic membrane currents showed a suppression by DNP of peak Na inward current without marked changes in the kinetics of the Na-carrying system and an increase of steady state outward current to three to five times its normal value. In42K tracer experiments, DNP increased K resting efflux by about 10% and decreased K influx by 25 to 30%. (3) The depression of Na inward current is regarded as being caused by a partial block of Na channels and an increase of internal Na concentration after inhibition of active Na extrusion. (4) The strong rise in outward current is probably not caused by a K current since K efflux fails to show a correspondingly large change. As a possible explanation for current and flux changes, an electrogenic K pump is discussed. (5) A mathematical model of a carrier system transporting a single ion species is described. The system is designed as a direct “potential” pump. Uphill transport requires an asymmetry of the rate constants governing the cyclic formation and breakdown of carrier-ion complex. The asymmetry is brought about by an input of metabolic energy. Reduction of energy input decreases the asymmetry and induces a carrier-mediated downhill ion movement, with corresponding changes in membrane current and ion fluxes. (6) A model of electrogenic K inward transport is calculated that approximately accounts for the steady state current and the K flux changes experimentally observed after inhibition. More... »

PAGES

180-209

References to SciGraph publications

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  • 1962-07. Kalium-Fluxe am Vorhof des Froschherzens in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1967-09. The dynamic chloride component of membrane current in Purkinje fibers in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1967-09. The effect of tetrodotoxin on the membrane current in cardiac muscle (Purkinje fibers) in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1968-06. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1964-09. Ein Vergleich zwischen Fluxmessungen und elektrischen Messungen am Myokard in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1956-01. Aktionspotential und Kontraktion des Herzmuskels im Sauerstoffmangel in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1964-03. Ionic currents in cardiac excitation in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1969-06. Existence and role of a slow inward current during the frog atrial action potential in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1959-09. Das Verhalten der cellulären Potentiale der Herzmuskulatur bei verschiedenen experimentellen „Insuffizienzformen“ in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1967-06. Untersuchungen zum Problem des aktiven K- und Na-Transports am Myokard in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1966-03. Kalium-Fluxe und Membranpotential am Froschvorhof in Abhängigkeit von der Kalium-Außenkonzentration in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01868015

    DOI

    http://dx.doi.org/10.1007/bf01868015

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010604945

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24174193


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