Nachweis der spenderorganspezifischen humoralen Antikörper in hyperakut und akut abgestoßenen Lungenallotransplantaten am Hund View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-06

AUTHORS

P. Möschl, G. Lubec, A. Keiler, G. Salem, S. Szalay

ABSTRACT

A method to eluat donororganspecific antibodies enabling direct and specific access to the pattern of humoral rejection after lung allotransplantation is demonstrated.The antibodies were evaluated quantitatively and qualitatively by elution of lung-grafts immunoglobulins and by a consequent investigation of the eluates using the passive haemagglutination- and indirect immunfluorescencetest against donors' lung-antigen.Humoral antidonorlung-antibodies could be proved in all rejected grafts belonging to sensitized as well as to unsensitized recipients. There can be seen a highly significant correlation when comparing the results of the passive haemagglutination and indirect immunfluorescence test (r = 0,93, p ≤ 0,01). On the other hand negative results of the investigations of eluates by lungantigens of other dogs show the specifity of humoral graft rejection.The surprising fact that there does not exist an essential difference between the results of sensitized and nonsensitized animals reveals a humoral immunresponse in hyperacute as well as in acute rejection. More... »

PAGES

99-107

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01851171

DOI

http://dx.doi.org/10.1007/bf01851171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013745828

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/794961


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