The dynamic chloride component of membrane current in Purkinje fibers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1967-09

AUTHORS

J. Dudel, K. Peper, R. Rüdel, W. Trautwein

ABSTRACT

In short Purkinje fibers the membrane potential was changed by a voltage clamp technique. The membrane was de- and repolarized using voltage steps or voltage changes at constant speeds. On depolarization from the resting potential, at −20 mV a positive (outward) current component appears which increases at more positive potentials. The peak of the positive current is delayed by about 20 ms relative to the start of the depolarization. The positive current is inactivated with a time constant of 50 ms. Time and voltage dependence of the positive current seem to be independent of the direction of potential change.The positive current is not affected by removal of extracellular sodium or potassium. In the absence as well as in the presence of sodium, removal of extracellular chloride markedly reduces the positive current. It is concluded that a time dependent chloride current is triggered above −20 mV. At more negative membrane potentials the chloride current is small.The positive chloride current is shown to be responsible for the early rapid repolarization from the crest of the spike to the plateau of the action potential.Preparations kept in chloride-free solutions display an increased excitatory sodium current during depolarization. More... »

PAGES

197-212

References to SciGraph publications

  • 1964-03. Ionic currents in cardiac excitation in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1967-09. The effect of tetrodotoxin on the membrane current in cardiac muscle (Purkinje fibers) in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1966-09. Excitatory membrane current in heart muscle (Purkinje fibers) in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1967-12. The potassium component of membrane current in Purkinje fibers in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1965-12. Die Wirkung verschiedener Anionen auf den isolierten Ranvierschen Schnürring in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01844100

    DOI

    http://dx.doi.org/10.1007/bf01844100

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018127420

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/5241426


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