Multiple myeloma among blacks and Whites in the United States: the role of chronic antigenic stimulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-11

AUTHORS

Denise Riedel Lewis, Linda M. Pottern, Linda Morris Brown, Debra T. Silverman, Richard B. Haves, Janet B. Schoenberg, Raymond S. Greenberg, G. Marie Swanson, Ann Grossbart Schwartz, Jonathan M. Liff, Robert N. Hoover

ABSTRACT

Multiple myeloma (MM) is twice as common among Blacks than Whites in the United States. The reasons for this racial disparity are unknown, and the etiology of this cancer, in general, is poorly understood. Repeated or chronic antigenic stimulation (CAS) of the immune system has been suggested as a risk factor. Previous case-control studies have reported inconsistent CAS associations based on evaluations of individual and biologic categories of medical conditions. Interview data from 573 cases and 2,131 population-based controls were used to investigate further the CAS hypothesis using an immunologically based approach, and to determine whether CAS accounts for the excess of myeloma among Blacks. Over 50 medical conditions were grouped into biologically and immunologically related categories, and B-cell- and T-cell-mediated response groups. Except for urinary tract infections among Black men (odds ratio [OR] = 2.0), no significantly increased risks of MM were observed. However, there was a suggestion of increased risk among Blacks with an increased exposure to anaphylactic conditions. Analysis by immunoglobulin type revealed significantly elevated risks of IgG myeloma with eczema (OR = 2.1), the biologic category 'allergic conditions' (OR = 1.6), and the immunologic category 'anaphylaxis response' (OR = 1.6) among Whites, with Blacks having slightly lower risks. Our findings do not support a causal relationship between CAS and MM, nor do they explain the higher incidence among Blacks. More... »

PAGES

529-539

References to SciGraph publications

  • 1988-05. Multiple myeloma – A case-control study in BRITISH JOURNAL OF CANCER
  • 1993-03. Epidemiology of the M-component immunoglobulin types of multiple myeloma in CANCER CAUSES & CONTROL
  • 1991. Multiple Myeloma Evolves from a Malignant Hematopoietic Stem Cell in EPIDEMIOLOGY AND BIOLOGY OF MULTIPLE MYELOMA
  • 1983-12. Allergies and agricultural exposure as risk factors for multiple myeloma in BRITISH JOURNAL OF CANCER
  • 1986-09. Case-control study of multiple myeloma and farming in BRITISH JOURNAL OF CANCER
  • 1991-05. Medical history and the risk of multiple myeloma in BRITISH JOURNAL OF CANCER
  • 1992-09. Leukemia, lymphoma, and multiple myeloma following selected medical conditions in CANCER CAUSES & CONTROL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01831381

    DOI

    http://dx.doi.org/10.1007/bf01831381

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041810693

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7827240


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