Experimental induction of primitive neuro-ectodermal tumours in rats: A re-appraisement of the ENU-model of neurocarcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

J. Vaquero, S. Oya, S. Coca, M. Zurita

ABSTRACT

A series of 122 experimental brain tumours, induced in the Wistar rat by means of prenatal exposition to ethyl-nitrosourea, were studied with histological, immunohistochemical and ultrastructural techniques. Although with conventional histological techniques, most of the induced tumours showed morphological features suggesting their classification as malignant schwannomas or oligodendroglioma-like neoplasms, their study by means of immunohistochemistry and electron microscopy suggested that they are, in fact, primitive neuroectodermal tumours, with a tendency toward neuronal differentiation. This finding obliges us to re-appraise the ethyl-nitrosourea model of neurocarcinogenesis and to consider its possible usefulness for the experimental study of therapeutic approaches with potential applications in human neuro-ectodermal neoplasms. More... »

PAGES

294-301

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01808630

DOI

http://dx.doi.org/10.1007/bf01808630

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020724119

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7754838


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