Epidermal growth factor receptors in human breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-09

AUTHORS

Rolando Pérez, María Pascual, Amparo Macías, Agustín Lage

ABSTRACT

The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer. More... »

PAGES

189-193

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01806484

DOI

http://dx.doi.org/10.1007/bf01806484

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019243118

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6091821


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placenta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba", 
          "id": "http://www.grid.ac/institutes/grid.488984.1", 
          "name": [
            "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rez", 
        "givenName": "Rolando", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba", 
          "id": "http://www.grid.ac/institutes/grid.488984.1", 
          "name": [
            "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pascual", 
        "givenName": "Mar\u00eda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba", 
          "id": "http://www.grid.ac/institutes/grid.488984.1", 
          "name": [
            "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mac\u00edas", 
        "givenName": "Amparo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba", 
          "id": "http://www.grid.ac/institutes/grid.488984.1", 
          "name": [
            "Instituto de Oncolog\u00eda y Radiobiolog\u00eda, MINSAP 29 y E, Habana 4, Cuba"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lage", 
        "givenName": "Agust\u00edn", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/194495a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006221676", 
          "https://doi.org/10.1038/194495a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/285250a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026672197", 
          "https://doi.org/10.1038/285250a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/267526a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017347695", 
          "https://doi.org/10.1038/267526a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1984-09", 
    "datePublishedReg": "1984-09-01", 
    "description": "The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01806484", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "human breast cancer", 
      "breast cancer", 
      "new biochemical markers", 
      "human breast carcinoma", 
      "epidermal growth factor receptor", 
      "growth factor receptor", 
      "receptor values", 
      "breast carcinoma", 
      "estradiol receptor", 
      "biochemical markers", 
      "growth factor", 
      "factor receptor", 
      "cancer", 
      "crude membrane fraction", 
      "specific binding", 
      "receptors", 
      "high affinity", 
      "carcinoma", 
      "tumors", 
      "membrane fraction", 
      "markers", 
      "EGF", 
      "factors", 
      "study", 
      "binding", 
      "capacity", 
      "affinity", 
      "samples", 
      "fraction", 
      "definition", 
      "values", 
      "low content", 
      "content"
    ], 
    "name": "Epidermal growth factor receptors in human breast cancer", 
    "pagination": "189-193", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019243118"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01806484"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6091821"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01806484", 
      "https://app.dimensions.ai/details/publication/pub.1019243118"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_179.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01806484"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01806484'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01806484'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01806484'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01806484'


 

This table displays all metadata directly associated to this object as RDF triples.

175 TRIPLES      21 PREDICATES      75 URIs      64 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01806484 schema:about N0aa8a76a4c704437964894fde9cd1e36
2 N25239a824ec045cbb9b794508a9f6ba1
3 N3b9c8ebd423140948d4b48842cfdd024
4 N4bb392c99eb2492d89d13e282b640753
5 N5bf99996223a44eca0dbb972ef1f2ff6
6 N6801c38e45f7409bbd472adf603db032
7 N693a8044fa044a7d84085737e8934d1e
8 N7257fb1decdd46eaaa922f9499fc5a44
9 Na3d2ba7bf9b2408f8e6c713723c8e52e
10 Nb5fba7cd203f4863a6da8cebd41a2faf
11 Nbd6addaad43247b88e0a3f83d9d0c171
12 Nd9c18815e6c84d9f8fa9d268ffea4c39
13 Ne03e723eb63c48f896b67a2bb9276115
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Nbb3d9e7135574508b19c59bbcc9d271b
17 schema:citation sg:pub.10.1038/194495a0
18 sg:pub.10.1038/267526a0
19 sg:pub.10.1038/285250a0
20 schema:datePublished 1984-09
21 schema:datePublishedReg 1984-09-01
22 schema:description The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N7193975bdf294ebb9713667ace3d2196
26 Nc76a00c788284e778d9f98a45daf25ad
27 sg:journal.1092777
28 schema:keywords EGF
29 affinity
30 binding
31 biochemical markers
32 breast cancer
33 breast carcinoma
34 cancer
35 capacity
36 carcinoma
37 content
38 crude membrane fraction
39 definition
40 epidermal growth factor receptor
41 estradiol receptor
42 factor receptor
43 factors
44 fraction
45 growth factor
46 growth factor receptor
47 high affinity
48 human breast cancer
49 human breast carcinoma
50 low content
51 markers
52 membrane fraction
53 new biochemical markers
54 receptor values
55 receptors
56 samples
57 specific binding
58 study
59 tumors
60 values
61 schema:name Epidermal growth factor receptors in human breast cancer
62 schema:pagination 189-193
63 schema:productId N287545c8232a42a59f8c0e06ffac6ad5
64 N295a13fd9c494221b3a83f98cfd4d7e7
65 Nc19315bb12ae4db380db313ee487013a
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019243118
67 https://doi.org/10.1007/bf01806484
68 schema:sdDatePublished 2022-09-02T15:46
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Nb7b1ce7590fd477ab93d6d41bb1dd2c8
71 schema:url https://doi.org/10.1007/bf01806484
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0aa8a76a4c704437964894fde9cd1e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Cell Membrane
77 rdf:type schema:DefinedTerm
78 N158cc34dd2f7449fafdbbae368b26b77 schema:affiliation grid-institutes:grid.488984.1
79 schema:familyName Lage
80 schema:givenName Agustín
81 rdf:type schema:Person
82 N1e49108ec71c41d796e0210a4a7af0c0 schema:affiliation grid-institutes:grid.488984.1
83 schema:familyName Pérez
84 schema:givenName Rolando
85 rdf:type schema:Person
86 N25239a824ec045cbb9b794508a9f6ba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Epidermal Growth Factor
88 rdf:type schema:DefinedTerm
89 N287545c8232a42a59f8c0e06ffac6ad5 schema:name pubmed_id
90 schema:value 6091821
91 rdf:type schema:PropertyValue
92 N295a13fd9c494221b3a83f98cfd4d7e7 schema:name dimensions_id
93 schema:value pub.1019243118
94 rdf:type schema:PropertyValue
95 N3b9c8ebd423140948d4b48842cfdd024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N40090d1f99e34d509ba0050cf67aae95 schema:affiliation grid-institutes:grid.488984.1
99 schema:familyName Pascual
100 schema:givenName María
101 rdf:type schema:Person
102 N4bb392c99eb2492d89d13e282b640753 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N5bf99996223a44eca0dbb972ef1f2ff6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Placenta
107 rdf:type schema:DefinedTerm
108 N6801c38e45f7409bbd472adf603db032 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Male
110 rdf:type schema:DefinedTerm
111 N693a8044fa044a7d84085737e8934d1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N7193975bdf294ebb9713667ace3d2196 schema:volumeNumber 4
115 rdf:type schema:PublicationVolume
116 N7257fb1decdd46eaaa922f9499fc5a44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Breast Neoplasms
118 rdf:type schema:DefinedTerm
119 N74c454d4b988497e96fe3bd418015886 schema:affiliation grid-institutes:grid.488984.1
120 schema:familyName Macías
121 schema:givenName Amparo
122 rdf:type schema:Person
123 Na3d2ba7bf9b2408f8e6c713723c8e52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Pregnancy
125 rdf:type schema:DefinedTerm
126 Na421e2b4183f4fef9059e08adbbfaa2a rdf:first N158cc34dd2f7449fafdbbae368b26b77
127 rdf:rest rdf:nil
128 Nb5fba7cd203f4863a6da8cebd41a2faf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Receptors, Cell Surface
130 rdf:type schema:DefinedTerm
131 Nb7b1ce7590fd477ab93d6d41bb1dd2c8 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Nbb3d9e7135574508b19c59bbcc9d271b rdf:first N1e49108ec71c41d796e0210a4a7af0c0
134 rdf:rest Nf9e4cd8572ee49358720df14db6510b3
135 Nbd6addaad43247b88e0a3f83d9d0c171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Kinetics
137 rdf:type schema:DefinedTerm
138 Nc19315bb12ae4db380db313ee487013a schema:name doi
139 schema:value 10.1007/bf01806484
140 rdf:type schema:PropertyValue
141 Nc76a00c788284e778d9f98a45daf25ad schema:issueNumber 3
142 rdf:type schema:PublicationIssue
143 Nd9c18815e6c84d9f8fa9d268ffea4c39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice
145 rdf:type schema:DefinedTerm
146 Ne03e723eb63c48f896b67a2bb9276115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name ErbB Receptors
148 rdf:type schema:DefinedTerm
149 Ne1128901075d4a51ae69477ab3bdcf1c rdf:first N74c454d4b988497e96fe3bd418015886
150 rdf:rest Na421e2b4183f4fef9059e08adbbfaa2a
151 Nf9e4cd8572ee49358720df14db6510b3 rdf:first N40090d1f99e34d509ba0050cf67aae95
152 rdf:rest Ne1128901075d4a51ae69477ab3bdcf1c
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
157 schema:name Oncology and Carcinogenesis
158 rdf:type schema:DefinedTerm
159 sg:journal.1092777 schema:issn 0167-6806
160 1573-7217
161 schema:name Breast Cancer Research and Treatment
162 schema:publisher Springer Nature
163 rdf:type schema:Periodical
164 sg:pub.10.1038/194495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006221676
165 https://doi.org/10.1038/194495a0
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/267526a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017347695
168 https://doi.org/10.1038/267526a0
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/285250a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026672197
171 https://doi.org/10.1038/285250a0
172 rdf:type schema:CreativeWork
173 grid-institutes:grid.488984.1 schema:alternateName Instituto de Oncología y Radiobiología, MINSAP 29 y E, Habana 4, Cuba
174 schema:name Instituto de Oncología y Radiobiología, MINSAP 29 y E, Habana 4, Cuba
175 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...