Chromosome localization of the human insulin gene in transgenic mouse lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-11

AUTHORS

Kyra Michalova, Danielle Bucchini, Marie-Anne Ripoche, Raymond Pictet, Jacques Jami

ABSTRACT

Three transgenic mouse lines, Tg 74, Tg 174, and Tg 171, were obtained by microinjection of an 11-kb human DNA fragment carrying the insulin gene into pronuclei of fertilized mouse eggs. The human insulin gene was expressed in all three transgenic mouse lines as shown by the presence of human C peptide in serum and urine and of human insulin transcripts in RNA prepared from pancreas. Several copies of the human DNA fragment arranged in head-to-tail arrays were present in each line. The human DNA insert was transmitted to the progeny as a single genetic locus. The chromosomal integration of the human insulin transgene was directly demonstrated by in situ hybridization to metaphase chromosomes of mitotic cells prepared from spleen and bone marrow. The insert appeared unique and located on a different chromosome in each line, namely 7 for Tg 74, 13 for Tg 174, and 18 for TG 171. Separation of DNA fragments larger than 20 kb by pulse-field electrophoresis showed that several insertion sites were present in each chromosome locus. This is the first direct evidence in transgenic mice that a gene located at various chromosome loci can be correctly expressed. More... »

PAGES

247-252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01790092

DOI

http://dx.doi.org/10.1007/bf01790092

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029028879

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3056832


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