Analysis ofHLA-DR and -DQ gene polymorphisms in sudanese patients with type 1 (insulin-dependent) diabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-11

AUTHORS

Mubarak M. A. Magzoub, Henrv A. F. Stephens, Edwin A. M. Gale, Gian Franco Bottazzo

ABSTRACT

In this study we report for the first time, the molecular analysis of HLA-DR and -DQ gene frequencies in a large cohort of well characterized type 1 (insulin-dependent) diabetes mellitus (IDDM) patients (n = 72), and ethnically matched controls (n = 59) collected in sub-Saharan Africa. High molecular mass DNA was prepared and analyzed in Southern blots with DRB1, DQA1, and DQB1 probes. By identifying DR and DQ allele-specific restriction fragment length polymorphisms (RFLPs), we have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2). A rare DR4, DQw2 haplotype was also identified at high frequency in the IDDM cohort. We can now confirm that the association between Asp 57-DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa. More... »

PAGES

366-371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01787486

DOI

http://dx.doi.org/10.1007/bf01787486

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041487954

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1684174


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Southern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Probes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DQ Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DR Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Restriction Fragment Length", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sudan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, Dominion House, St. Bartholomew's Hospital, West Smithfield, EClA 7BE, London, England", 
            "Faculty of Medicine, University of Gezera, Wad Madani, Sudan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magzoub", 
        "givenName": "Mubarak M. A.", 
        "id": "sg:person.011237132674.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011237132674.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, Dominion House, St. Bartholomew's Hospital, West Smithfield, EClA 7BE, London, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephens", 
        "givenName": "Henrv A. F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, Dominion House, St. Bartholomew's Hospital, West Smithfield, EClA 7BE, London, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gale", 
        "givenName": "Edwin A. M.", 
        "id": "sg:person.012062434302.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012062434302.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Department of Immunology, The London Hospital Medical College, E1 2AD, London, England"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bottazzo", 
        "givenName": "Gian Franco", 
        "id": "sg:person.0723572726.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00345500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005918602", 
          "https://doi.org/10.1007/bf00345500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329599a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006612244", 
          "https://doi.org/10.1038/329599a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.79.12.3687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006862657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00230506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008244990", 
          "https://doi.org/10.1007/bf00230506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00230506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008244990", 
          "https://doi.org/10.1007/bf00230506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(89)90040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010533890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(89)90040-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010533890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010942979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1985.tb00429.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014680370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018637472", 
          "https://doi.org/10.1007/bf02421540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018637472", 
          "https://doi.org/10.1007/bf02421540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1985.tb00930.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018910782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1989.tb01693.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019427312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.3.1094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020449567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.19.7370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021823467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(89)90018-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024583776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(89)90018-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024583776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1989.tb02098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024725816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.21.8111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030380892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1990.tb01749.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030584188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1987.tb01621.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031250419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1988.tb02072.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033176089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033612532", 
          "https://doi.org/10.1007/bf00265368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033612532", 
          "https://doi.org/10.1007/bf00265368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00265368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033612532", 
          "https://doi.org/10.1007/bf00265368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1981.tb09793.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035144896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1981.tb09793.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035144896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(90)90143-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037592769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(90)90143-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037592769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00252257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040690169", 
          "https://doi.org/10.1007/bf00252257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00252257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040690169", 
          "https://doi.org/10.1007/bf00252257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00252257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040690169", 
          "https://doi.org/10.1007/bf00252257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1990.tb01812.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042856700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1990.tb01753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043941885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1985.tb02232.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045098664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/338587a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047000342", 
          "https://doi.org/10.1038/338587a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1987.tb01581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047831590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1990.tb01759.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048081594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199006283222602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050078436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050352836", 
          "https://doi.org/10.1007/bf02421199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050352836", 
          "https://doi.org/10.1007/bf02421199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02341501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050888393", 
          "https://doi.org/10.1007/bf02341501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02341501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050888393", 
          "https://doi.org/10.1007/bf02341501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1988.tb02070.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052194220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3368786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062609753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.35.5.583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078888083", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079442663", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb01826.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081840401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb02026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081843081"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1991-11", 
    "datePublishedReg": "1991-11-01", 
    "description": "In this study we report for the first time, the molecular analysis of HLA-DR and -DQ gene frequencies in a large cohort of well characterized type 1 (insulin-dependent) diabetes mellitus (IDDM) patients (n = 72), and ethnically matched controls (n = 59) collected in sub-Saharan Africa. High molecular mass DNA was prepared and analyzed in Southern blots with DRB1, DQA1, and DQB1 probes. By identifying DR and DQ allele-specific restriction fragment length polymorphisms (RFLPs), we have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2). A rare DR4, DQw2 haplotype was also identified at high frequency in the IDDM cohort. We can now confirm that the association between Asp 57-DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01787486", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019755", 
        "issn": [
          "0093-7711", 
          "1432-1211"
        ], 
        "name": "Immunogenetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Analysis ofHLA-DR and -DQ gene polymorphisms in sudanese patients with type 1 (insulin-dependent) diabetes", 
    "pagination": "366-371", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c5a318239e4498ad8de5e0463c843c584da9887c24d501b98b596cc6b62b3708"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1684174"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0420404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01787486"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041487954"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01787486", 
      "https://app.dimensions.ai/details/publication/pub.1041487954"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113647_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01787486"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01787486'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01787486'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01787486'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01787486'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      84 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01787486 schema:about N4068e7ac32c6432dbecaac00df6aac3d
2 N4426431672ca495a8cde4eb10a5cc308
3 N5400b15ff76844208f9ec4173d9d054b
4 N5bfeda69a51f4f3bb59857597ef80333
5 N6e8807230966462e818d3939cd5a1bab
6 N7c8687e513b745e6a524cc5a2261680f
7 N7d749408510443deb84b17e4e03d5c97
8 N7e6d85f914f94240a63626614b64771e
9 N8cc9da94fb4c482fb362d1d0ce82654f
10 N9a8ebbdc4db34accb8520664f5a39d11
11 Nb5409ee186394f9f8fcf5f9a4e64ec5a
12 Nb80929e2f8e3431a8891f0f6e490d99e
13 Nbdb8c750325c4ea28c635e483c0a5606
14 Nbe64e3f2e33048dcb525bbadae769e36
15 Ncdbed6a7023c43e38bbc9fd91d21ec90
16 Nd98e0c7526a544549126ec43c8d7525a
17 Nfe39602c46694bf6b82d8ac36213db7c
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author Nd84a2e65abb7425697756ff5135ae3ee
21 schema:citation sg:pub.10.1007/bf00230506
22 sg:pub.10.1007/bf00252257
23 sg:pub.10.1007/bf00265368
24 sg:pub.10.1007/bf00345500
25 sg:pub.10.1007/bf02341501
26 sg:pub.10.1007/bf02421199
27 sg:pub.10.1007/bf02421540
28 sg:pub.10.1038/329599a0
29 sg:pub.10.1038/338587a0
30 https://app.dimensions.ai/details/publication/pub.1078888083
31 https://app.dimensions.ai/details/publication/pub.1079442663
32 https://doi.org/10.1002/j.1460-2075.1984.tb01826.x
33 https://doi.org/10.1002/j.1460-2075.1984.tb02026.x
34 https://doi.org/10.1016/0161-5890(90)90143-n
35 https://doi.org/10.1016/0198-8859(89)90018-9
36 https://doi.org/10.1016/0198-8859(89)90040-2
37 https://doi.org/10.1056/nejm199006283222602
38 https://doi.org/10.1073/pnas.79.12.3687
39 https://doi.org/10.1073/pnas.85.21.8111
40 https://doi.org/10.1073/pnas.87.19.7370
41 https://doi.org/10.1073/pnas.87.3.1094
42 https://doi.org/10.1111/j.0954-6820.1981.tb09793.x
43 https://doi.org/10.1111/j.1399-0039.1985.tb00429.x
44 https://doi.org/10.1111/j.1399-0039.1985.tb00930.x
45 https://doi.org/10.1111/j.1399-0039.1985.tb02232.x
46 https://doi.org/10.1111/j.1399-0039.1987.tb01581.x
47 https://doi.org/10.1111/j.1399-0039.1987.tb01621.x
48 https://doi.org/10.1111/j.1399-0039.1988.tb02070.x
49 https://doi.org/10.1111/j.1399-0039.1988.tb02072.x
50 https://doi.org/10.1111/j.1399-0039.1989.tb01693.x
51 https://doi.org/10.1111/j.1399-0039.1989.tb02098.x
52 https://doi.org/10.1111/j.1399-0039.1990.tb01749.x
53 https://doi.org/10.1111/j.1399-0039.1990.tb01753.x
54 https://doi.org/10.1111/j.1399-0039.1990.tb01759.x
55 https://doi.org/10.1111/j.1399-0039.1990.tb01812.x
56 https://doi.org/10.1126/science.3368786
57 https://doi.org/10.1172/jci114569
58 https://doi.org/10.2337/diab.35.5.583
59 schema:datePublished 1991-11
60 schema:datePublishedReg 1991-11-01
61 schema:description In this study we report for the first time, the molecular analysis of HLA-DR and -DQ gene frequencies in a large cohort of well characterized type 1 (insulin-dependent) diabetes mellitus (IDDM) patients (n = 72), and ethnically matched controls (n = 59) collected in sub-Saharan Africa. High molecular mass DNA was prepared and analyzed in Southern blots with DRB1, DQA1, and DQB1 probes. By identifying DR and DQ allele-specific restriction fragment length polymorphisms (RFLPs), we have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2). A rare DR4, DQw2 haplotype was also identified at high frequency in the IDDM cohort. We can now confirm that the association between Asp 57-DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N192c32c2ff64449ea78c7221cf3c6496
66 N26f5ffea5db644568f81e05173539bf3
67 sg:journal.1019755
68 schema:name Analysis ofHLA-DR and -DQ gene polymorphisms in sudanese patients with type 1 (insulin-dependent) diabetes
69 schema:pagination 366-371
70 schema:productId N39c19207c5cc4fa5b030806920ecb633
71 N45a4305d8d8a4bda98733599131b3a81
72 N79834e1020e74f1c95de384ef96c50a8
73 N97725e554a414c4b8ac93fcd0c985f83
74 Nd725abb4746e4980be6564f957253f29
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041487954
76 https://doi.org/10.1007/bf01787486
77 schema:sdDatePublished 2019-04-11T10:30
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N2d29a1ffe0d44424b2ccb78ec7563839
80 schema:url http://link.springer.com/10.1007/BF01787486
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N192c32c2ff64449ea78c7221cf3c6496 schema:volumeNumber 34
85 rdf:type schema:PublicationVolume
86 N26f5ffea5db644568f81e05173539bf3 schema:issueNumber 6
87 rdf:type schema:PublicationIssue
88 N2d29a1ffe0d44424b2ccb78ec7563839 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N33c4998b29714532862d5b9df185769c rdf:first N6f62b62f2c6d455b80d8f838560bceb3
91 rdf:rest N460c220c9d3041ddab4a17a8bda66fa9
92 N39c19207c5cc4fa5b030806920ecb633 schema:name readcube_id
93 schema:value c5a318239e4498ad8de5e0463c843c584da9887c24d501b98b596cc6b62b3708
94 rdf:type schema:PropertyValue
95 N4068e7ac32c6432dbecaac00df6aac3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name HLA-DR Antigens
97 rdf:type schema:DefinedTerm
98 N4426431672ca495a8cde4eb10a5cc308 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Male
100 rdf:type schema:DefinedTerm
101 N45a4305d8d8a4bda98733599131b3a81 schema:name pubmed_id
102 schema:value 1684174
103 rdf:type schema:PropertyValue
104 N460c220c9d3041ddab4a17a8bda66fa9 rdf:first sg:person.012062434302.19
105 rdf:rest N61e4df0e4e8e4317b6e68747079aae8d
106 N5400b15ff76844208f9ec4173d9d054b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Polymorphism, Restriction Fragment Length
108 rdf:type schema:DefinedTerm
109 N5bfeda69a51f4f3bb59857597ef80333 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adult
111 rdf:type schema:DefinedTerm
112 N61e4df0e4e8e4317b6e68747079aae8d rdf:first sg:person.0723572726.20
113 rdf:rest rdf:nil
114 N6e8807230966462e818d3939cd5a1bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Haplotypes
116 rdf:type schema:DefinedTerm
117 N6f62b62f2c6d455b80d8f838560bceb3 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
118 schema:familyName Stephens
119 schema:givenName Henrv A. F.
120 rdf:type schema:Person
121 N79834e1020e74f1c95de384ef96c50a8 schema:name doi
122 schema:value 10.1007/bf01787486
123 rdf:type schema:PropertyValue
124 N7c8687e513b745e6a524cc5a2261680f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name DNA Probes
126 rdf:type schema:DefinedTerm
127 N7d749408510443deb84b17e4e03d5c97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name HLA-DQ Antigens
129 rdf:type schema:DefinedTerm
130 N7e6d85f914f94240a63626614b64771e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 N8cc9da94fb4c482fb362d1d0ce82654f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N97725e554a414c4b8ac93fcd0c985f83 schema:name dimensions_id
137 schema:value pub.1041487954
138 rdf:type schema:PropertyValue
139 N9a8ebbdc4db34accb8520664f5a39d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Diabetes Mellitus, Type 1
141 rdf:type schema:DefinedTerm
142 Nb5409ee186394f9f8fcf5f9a4e64ec5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Child
144 rdf:type schema:DefinedTerm
145 Nb80929e2f8e3431a8891f0f6e490d99e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sudan
147 rdf:type schema:DefinedTerm
148 Nbdb8c750325c4ea28c635e483c0a5606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Immunophenotyping
150 rdf:type schema:DefinedTerm
151 Nbe64e3f2e33048dcb525bbadae769e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Polymorphism, Genetic
153 rdf:type schema:DefinedTerm
154 Ncdbed6a7023c43e38bbc9fd91d21ec90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Blotting, Southern
156 rdf:type schema:DefinedTerm
157 Nd725abb4746e4980be6564f957253f29 schema:name nlm_unique_id
158 schema:value 0420404
159 rdf:type schema:PropertyValue
160 Nd84a2e65abb7425697756ff5135ae3ee rdf:first sg:person.011237132674.88
161 rdf:rest N33c4998b29714532862d5b9df185769c
162 Nd98e0c7526a544549126ec43c8d7525a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adolescent
164 rdf:type schema:DefinedTerm
165 Nfe39602c46694bf6b82d8ac36213db7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Frequency
167 rdf:type schema:DefinedTerm
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
172 schema:name Genetics
173 rdf:type schema:DefinedTerm
174 sg:journal.1019755 schema:issn 0093-7711
175 1432-1211
176 schema:name Immunogenetics
177 rdf:type schema:Periodical
178 sg:person.011237132674.88 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
179 schema:familyName Magzoub
180 schema:givenName Mubarak M. A.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011237132674.88
182 rdf:type schema:Person
183 sg:person.012062434302.19 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
184 schema:familyName Gale
185 schema:givenName Edwin A. M.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012062434302.19
187 rdf:type schema:Person
188 sg:person.0723572726.20 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
189 schema:familyName Bottazzo
190 schema:givenName Gian Franco
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20
192 rdf:type schema:Person
193 sg:pub.10.1007/bf00230506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008244990
194 https://doi.org/10.1007/bf00230506
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/bf00252257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040690169
197 https://doi.org/10.1007/bf00252257
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/bf00265368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033612532
200 https://doi.org/10.1007/bf00265368
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/bf00345500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005918602
203 https://doi.org/10.1007/bf00345500
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf02341501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050888393
206 https://doi.org/10.1007/bf02341501
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/bf02421199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050352836
209 https://doi.org/10.1007/bf02421199
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/bf02421540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018637472
212 https://doi.org/10.1007/bf02421540
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/329599a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006612244
215 https://doi.org/10.1038/329599a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/338587a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047000342
218 https://doi.org/10.1038/338587a0
219 rdf:type schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1078888083 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1079442663 schema:CreativeWork
222 https://doi.org/10.1002/j.1460-2075.1984.tb01826.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081840401
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/j.1460-2075.1984.tb02026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081843081
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0161-5890(90)90143-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1037592769
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0198-8859(89)90018-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024583776
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0198-8859(89)90040-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010533890
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1056/nejm199006283222602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050078436
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1073/pnas.79.12.3687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006862657
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.85.21.8111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030380892
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.87.19.7370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021823467
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1073/pnas.87.3.1094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020449567
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1111/j.0954-6820.1981.tb09793.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035144896
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1399-0039.1985.tb00429.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014680370
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1399-0039.1985.tb00930.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018910782
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1399-0039.1985.tb02232.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045098664
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1399-0039.1987.tb01581.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047831590
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1399-0039.1987.tb01621.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031250419
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1111/j.1399-0039.1988.tb02070.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052194220
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/j.1399-0039.1988.tb02072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033176089
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1399-0039.1989.tb01693.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019427312
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1399-0039.1989.tb02098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024725816
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1399-0039.1990.tb01749.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030584188
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1399-0039.1990.tb01753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043941885
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1399-0039.1990.tb01759.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048081594
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1399-0039.1990.tb01812.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042856700
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1126/science.3368786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062609753
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1172/jci114569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010942979
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2337/diab.35.5.583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735037
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.416353.6 schema:alternateName St Bartholomew's Hospital
277 schema:name Department of Diabetes and Immunogenetics, Dominion House, St. Bartholomew's Hospital, West Smithfield, EClA 7BE, London, England
278 Faculty of Medicine, University of Gezera, Wad Madani, Sudan
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
281 schema:name Department of Immunology, The London Hospital Medical College, E1 2AD, London, England
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...