Polymorphism ofTcrb andTcrg genes in Biozzi mice: Segregation analysis of a newTcrg haplotype with antibody responsiveness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-01

AUTHORS

Laurent Vidard, Thierry Roger, Ghislaine Pham, Jacques Couderc, Yolande Bouthillier, Jean-Claude Mevel, Denise Mouton, Michel Seman

ABSTRACT

Tcrb andTcrg gene polymorphism was investigated in high (H) and low (L) responder Biozzi mice from selection I, II, and GS by Southern blot analysis with appropriateV andC probes. No polymorphism of theTcrb haplotype was detected between H and L mice in all selections which were all found to be of the BALB/c type. The H-I and H-II g genotype was of BALB/c and DBA/2 type, respectively. In contrast, a newTcrg haplotype shared by L-I and L-II mice was identified and characterized by Cγ1, 2, 3, Cγ4, Vγ1, 2, 3, Vγ5, and Vγ6 restriction fragment length polymorphisms (RFLPs).Tcrg genotypes were not fixed in the GS selection and two additional new haplotypes were identified in two L-GS mice. An attempt was made to correlate the L-Ig genotype with the low responder status by analyzingg haplotypes among highest and lowest responder (H-1 x L-I)F2 hybrids immunized with sheep red blood cells (SRBC). No correlation was found in this segregation study, whereas a highly significant one was established with theH-2 haplotype, a locus already known to participate in the genetic control of H-I/L-I difference. The lack of correlation between SRBC response and theTcrg genotype was consistent with the heterogenousg haplotypes found in mice of the GS selection. Together, the present results suggest that H and L mice have the sameTcrab potential repertoire and that T-cell receptor (Tcr) genes cannot be considered as immune response genes in this model. Our results also indicate that the F2 segregation analysis, given a polymorphic gene, is suitable for an investigation of its immune response functions. More... »

PAGES

27-33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01787325

DOI

http://dx.doi.org/10.1007/bf01787325

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016353154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1973682


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52 Vγ1
53 Vγ5
54 Vγ6 restriction fragment length polymorphisms
55 additional new haplotypes
56 analysis
57 analyzingg haplotypes
58 andC probes
59 andTcrg gene polymorphism
60 andTcrg genes
61 antibody responsiveness
62 appropriateV andC probes
63 attempt
64 blood cells
65 blot analysis
66 c type
67 cell receptor genes
68 cells
69 contrast
70 control
71 correlation
72 differences
73 fragment length polymorphism
74 function
75 gene polymorphisms
76 genes
77 genetic control
78 genotypes
79 haplotypes
80 heterogenousg haplotypes
81 hybrids
82 immune response functions
83 immune response genes
84 investigation
85 lack
86 lack of correlation
87 length polymorphism
88 loci
89 low responder status
90 low responders
91 mice
92 model
93 new haplotypes
94 newTcrg haplotype
95 ofTcrb andTcrg genes
96 one
97 polymorphic genes
98 polymorphism
99 potential repertoire
100 present results
101 probe
102 receptor gene
103 red blood cells
104 repertoire
105 responder status
106 responders
107 response
108 response function
109 response genes
110 responsiveness
111 restriction fragment length polymorphism
112 results
113 sameTcrab potential repertoire
114 segregation analysis
115 segregation studies
116 selection
117 selection I
118 sheep red blood cells
119 significant ones
120 status
121 study
122 theH-2 haplotype
123 theTcrg genotype
124 types
125 x L
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