Treatment of chemically induced autochthonous rat mammary and colorectal carcinomas with interleukin-2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

Martin R. Berger, Margaretha Salas, Felix Garzon, Edgar Petru, Udo Schwulera, Dietrich Schmähl

ABSTRACT

The antineoplastic efficacy of human interleukin-2 (IL-2) in autochthonous methylnitrosourea-induced mammary carcinoma and in acetoxymethly-methylnitrosamine-induced colorectal carcinoma of Sprague Dawley rats has been investigated. Under the conditions applied, IL-2 was non-toxic. In the mammary carcinoma IL-2 was therapeutically inactive. In the colorectal carcinoma, 1200 U IL-2/day exhibited significant antitumour activity in established tumours as well as in tumours treated “prophylactically” before their manifestation (P <0.05). The effect of IL-2 seemed to be more pronounced when given before manifestation of colorectal tumours (T/C = 8.7% vs 17.8% in established tumours). The differential sensitivity of the autochthonous mammary and colorectal carcinoma may be explained by differences in their proliferation rates and differences in volumes at the beginning of IL-2 therapy. IL-2 seems to be preferentially active in small tumours with a low proliferation rate, a feature typical of colon tumours More... »

PAGES

346-349

References to SciGraph publications

  • 1988-10. The clinical potential of interleukin-2 in BRITISH JOURNAL OF CANCER
  • 1988-10. Efficacy of chemoimmunotherapy with cyclophosphamide, interleukin-2 and lymphokine activated killer cells in an intraperitoneal murine tumour model in BRITISH JOURNAL OF CANCER
  • 1986-09. Effect of recombinant interleukin 2 (R-IL2) on in vivo growth of murine myeloma X5563 in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1989-11. Evidence of a role for NK cells in oxazaphosphorine-mediated tumor regression in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1989-05. Chemo-immunotherapy of murine tumors using interleukin-2 (IL-2) and cyclophosphamide in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1990-01. Adoptive immunotherapy of a mouse colon carcinoma with recombinant interleukin-2 alone or combined with lymphokine-activated killer cells or tumor-immune lymphocytes in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1988-06. Improved therapeutic effects of interleukin 2 after the accumulation of lymphokine-activated killer cells in tumor tissue of mice previously treated with cyclophosphamide in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 1987-08. Therapeutic ratio of mono or combination bacterial lipopolysaccharide therapy in methylnitrosourea — induced rat mammary carcinoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1986-02. Effect of interleukin-2 on the manifestation and growth of acetoxymethyl-methylnitrosamine-induced colorectal rat adenocarcinoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 1989-03. Therapeutic efficacy of human recombinant interleukin-2 (TGP-3) alone or in combination with cyclophosphamide and immunocompetent cells in allogeneic, semi-syngeneic, and syngeneic murine tumors in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01756601

    DOI

    http://dx.doi.org/10.1007/bf01756601

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032493849

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1868493


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