On the cysteine and cystine content of proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-06

AUTHORS

Robert C. Fahey, John S. Hunt, Gayle C. Windham

ABSTRACT

Analysis of published data on the cysteine and half-cystine content of proteins indicates that most intracellular proteins may be classified as sulfhydryl proteins (those containing cysteine but little or no half-cystine) and that such sulf-hydryl proteins have a low cysteine content. The mean cysteine content found for 32 intracellular mammalian proteins was 1.6 % and intracellular proteins of many bacteria have similar or lower values. Extracellular mammalian proteins are primarily disulfide proteins (those containing half-cystine but little or no cysteine) and have a high half-cystine content, the mean value found for some 34 extracellular mammalian proteins being 4.1 %. This is contrasted with many of the extracellular proteins from facultative bacteria which are cyst(e)ine-free proteins, being lacking in both cysteine and half-cystine. These and related observations are interpreted in terms of the evolution of life in a reducing atmosphere and the subsequent transition to an oxidizing environment. It is suggested that disulfide proteins evolved primarily after the accumulation of oxygen in the atmosphere. More... »

PAGES

155-160

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01751808

DOI

http://dx.doi.org/10.1007/bf01751808

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002350968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/592421


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Evolution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Space", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fahey", 
        "givenName": "Robert C.", 
        "id": "sg:person.01252302476.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252302476.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunt", 
        "givenName": "John S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Windham", 
        "givenName": "Gayle C.", 
        "id": "sg:person.01013655530.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013655530.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01797453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787887", 
          "https://doi.org/10.1007/bf01797453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/228438a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033200917", 
          "https://doi.org/10.1038/228438a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01731488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032483985", 
          "https://doi.org/10.1007/bf01731488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/194446a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049162340", 
          "https://doi.org/10.1038/194446a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01732532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034809571", 
          "https://doi.org/10.1007/bf01732532"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1977-06", 
    "datePublishedReg": "1977-06-01", 
    "description": "Analysis of published data on the cysteine and half-cystine content of proteins indicates that most intracellular proteins may be classified as sulfhydryl proteins (those containing cysteine but little or no half-cystine) and that such sulf-hydryl proteins have a low cysteine content. The mean cysteine content found for 32 intracellular mammalian proteins was 1.6 % and intracellular proteins of many bacteria have similar or lower values. Extracellular mammalian proteins are primarily disulfide proteins (those containing half-cystine but little or no cysteine) and have a high half-cystine content, the mean value found for some 34 extracellular mammalian proteins being 4.1 %. This is contrasted with many of the extracellular proteins from facultative bacteria which are cyst(e)ine-free proteins, being lacking in both cysteine and half-cystine. These and related observations are interpreted in terms of the evolution of life in a reducing atmosphere and the subsequent transition to an oxidizing environment. It is suggested that disulfide proteins evolved primarily after the accumulation of oxygen in the atmosphere.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf01751808", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016442", 
        "issn": [
          "0022-2844", 
          "1432-1432"
        ], 
        "name": "Journal of Molecular Evolution", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "half-cystine content", 
      "mammalian proteins", 
      "disulfide proteins", 
      "intracellular proteins", 
      "high half-cystine content", 
      "intracellular mammalian proteins", 
      "cysteine content", 
      "most intracellular proteins", 
      "evolution of life", 
      "low cysteine content", 
      "extracellular proteins", 
      "protein", 
      "free protein", 
      "sulfhydryl proteins", 
      "cysteine", 
      "bacteria", 
      "facultative bacteria", 
      "accumulation of oxygen", 
      "cystine content", 
      "related observations", 
      "accumulation", 
      "subsequent transition", 
      "oxidizing environment", 
      "evolution", 
      "content", 
      "environment", 
      "analysis", 
      "oxygen", 
      "observations", 
      "lower values", 
      "data", 
      "transition", 
      "values", 
      "life", 
      "mean value", 
      "atmosphere", 
      "terms", 
      "such sulf-hydryl proteins", 
      "sulf-hydryl proteins", 
      "mean cysteine content", 
      "Extracellular mammalian proteins"
    ], 
    "name": "On the cysteine and cystine content of proteins", 
    "pagination": "155-160", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002350968"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01751808"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "592421"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01751808", 
      "https://app.dimensions.ai/details/publication/pub.1002350968"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_142.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf01751808"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01751808'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01751808'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01751808'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01751808'


 

This table displays all metadata directly associated to this object as RDF triples.

164 TRIPLES      22 PREDICATES      80 URIs      67 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01751808 schema:about N224bff1a011745b18c13fb751ebdbdda
2 N428b246fb78048e9ae1d7b9be7dcd825
3 N698c6610c58748b2929cd8bce6657330
4 N79fb206c9731449c8e2455bcd14586a3
5 N7ceb266820354b9c959b21b8607af8b7
6 Na95686c270be4d1585ac5896cff53197
7 Nfe75bfd41ffa4dcca8b2c706b90d57c5
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author N05eeb4b2d19645e4902f12d4c952b39a
11 schema:citation sg:pub.10.1007/bf01731488
12 sg:pub.10.1007/bf01732532
13 sg:pub.10.1007/bf01797453
14 sg:pub.10.1038/194446a0
15 sg:pub.10.1038/228438a0
16 schema:datePublished 1977-06
17 schema:datePublishedReg 1977-06-01
18 schema:description Analysis of published data on the cysteine and half-cystine content of proteins indicates that most intracellular proteins may be classified as sulfhydryl proteins (those containing cysteine but little or no half-cystine) and that such sulf-hydryl proteins have a low cysteine content. The mean cysteine content found for 32 intracellular mammalian proteins was 1.6 % and intracellular proteins of many bacteria have similar or lower values. Extracellular mammalian proteins are primarily disulfide proteins (those containing half-cystine but little or no cysteine) and have a high half-cystine content, the mean value found for some 34 extracellular mammalian proteins being 4.1 %. This is contrasted with many of the extracellular proteins from facultative bacteria which are cyst(e)ine-free proteins, being lacking in both cysteine and half-cystine. These and related observations are interpreted in terms of the evolution of life in a reducing atmosphere and the subsequent transition to an oxidizing environment. It is suggested that disulfide proteins evolved primarily after the accumulation of oxygen in the atmosphere.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N0cb9b5b23fd94c93b51dff754fac5791
23 Nabccb5df5dc14813b68ce1360d3bbe99
24 sg:journal.1016442
25 schema:keywords Extracellular mammalian proteins
26 accumulation
27 accumulation of oxygen
28 analysis
29 atmosphere
30 bacteria
31 content
32 cysteine
33 cysteine content
34 cystine content
35 data
36 disulfide proteins
37 environment
38 evolution
39 evolution of life
40 extracellular proteins
41 facultative bacteria
42 free protein
43 half-cystine content
44 high half-cystine content
45 intracellular mammalian proteins
46 intracellular proteins
47 life
48 low cysteine content
49 lower values
50 mammalian proteins
51 mean cysteine content
52 mean value
53 most intracellular proteins
54 observations
55 oxidizing environment
56 oxygen
57 protein
58 related observations
59 subsequent transition
60 such sulf-hydryl proteins
61 sulf-hydryl proteins
62 sulfhydryl proteins
63 terms
64 transition
65 values
66 schema:name On the cysteine and cystine content of proteins
67 schema:pagination 155-160
68 schema:productId N78ac9e61a7cb4802977f99ca0dc5d25d
69 N7f4f1497d7c943418cee8a7b75f22ac4
70 N8fe34dc5c0c843179187190937ab8019
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002350968
72 https://doi.org/10.1007/bf01751808
73 schema:sdDatePublished 2021-12-01T19:03
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nde31ca33082347e5875b9ba16ddd19e8
76 schema:url https://doi.org/10.1007/bf01751808
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N05eeb4b2d19645e4902f12d4c952b39a rdf:first sg:person.01252302476.55
81 rdf:rest N234c744bb16b4f6180d9309214f45188
82 N0cb9b5b23fd94c93b51dff754fac5791 schema:volumeNumber 10
83 rdf:type schema:PublicationVolume
84 N224bff1a011745b18c13fb751ebdbdda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Bacterial Proteins
86 rdf:type schema:DefinedTerm
87 N234c744bb16b4f6180d9309214f45188 rdf:first N72c0947d34024293ab97a05360982953
88 rdf:rest N89ca2ae520844fb59dd0084dd71715e1
89 N428b246fb78048e9ae1d7b9be7dcd825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cysteine
91 rdf:type schema:DefinedTerm
92 N698c6610c58748b2929cd8bce6657330 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Cystine
94 rdf:type schema:DefinedTerm
95 N72c0947d34024293ab97a05360982953 schema:affiliation grid-institutes:None
96 schema:familyName Hunt
97 schema:givenName John S.
98 rdf:type schema:Person
99 N78ac9e61a7cb4802977f99ca0dc5d25d schema:name dimensions_id
100 schema:value pub.1002350968
101 rdf:type schema:PropertyValue
102 N79fb206c9731449c8e2455bcd14586a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Environment
104 rdf:type schema:DefinedTerm
105 N7ceb266820354b9c959b21b8607af8b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Biological Evolution
107 rdf:type schema:DefinedTerm
108 N7f4f1497d7c943418cee8a7b75f22ac4 schema:name doi
109 schema:value 10.1007/bf01751808
110 rdf:type schema:PropertyValue
111 N89ca2ae520844fb59dd0084dd71715e1 rdf:first sg:person.01013655530.48
112 rdf:rest rdf:nil
113 N8fe34dc5c0c843179187190937ab8019 schema:name pubmed_id
114 schema:value 592421
115 rdf:type schema:PropertyValue
116 Na95686c270be4d1585ac5896cff53197 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Extracellular Space
118 rdf:type schema:DefinedTerm
119 Nabccb5df5dc14813b68ce1360d3bbe99 schema:issueNumber 2
120 rdf:type schema:PublicationIssue
121 Nde31ca33082347e5875b9ba16ddd19e8 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Nfe75bfd41ffa4dcca8b2c706b90d57c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Proteins
125 rdf:type schema:DefinedTerm
126 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
127 schema:name Biological Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
130 schema:name Biochemistry and Cell Biology
131 rdf:type schema:DefinedTerm
132 sg:journal.1016442 schema:issn 0022-2844
133 1432-1432
134 schema:name Journal of Molecular Evolution
135 schema:publisher Springer Nature
136 rdf:type schema:Periodical
137 sg:person.01013655530.48 schema:affiliation grid-institutes:None
138 schema:familyName Windham
139 schema:givenName Gayle C.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013655530.48
141 rdf:type schema:Person
142 sg:person.01252302476.55 schema:affiliation grid-institutes:None
143 schema:familyName Fahey
144 schema:givenName Robert C.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252302476.55
146 rdf:type schema:Person
147 sg:pub.10.1007/bf01731488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032483985
148 https://doi.org/10.1007/bf01731488
149 rdf:type schema:CreativeWork
150 sg:pub.10.1007/bf01732532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034809571
151 https://doi.org/10.1007/bf01732532
152 rdf:type schema:CreativeWork
153 sg:pub.10.1007/bf01797453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052787887
154 https://doi.org/10.1007/bf01797453
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/194446a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049162340
157 https://doi.org/10.1038/194446a0
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/228438a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033200917
160 https://doi.org/10.1038/228438a0
161 rdf:type schema:CreativeWork
162 grid-institutes:None schema:alternateName Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA
163 schema:name Department of Chemistry, University of California, 92093, San Diego, La Jolla, CA, USA
164 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...