Usefulness of electron microscopy in the diagnosis of cardiac sarcoidosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-10

AUTHORS

Genzou Takemura, Yoshiki Takatsu, Koh Ono, Toshiyuki Miyatake, Mayumi Ono, Toshiaki Izumi, Hisayoshi Fujiwara

ABSTRACT

A 49-year-old man with cardiac sarcoidosis is presented. He suffered from congestive heart failure, and left ventricular asynergy and reduced function was evident by echocardiogram and left ventriculogram. A light microscopic examination of the endomyocardial biopsy revealed nonspecific myocarditis without giant cells or noncaseating granulomas. Under an electron microscope, however, several epithelioid cells were found in the specimen. The serum level of lysozyme was elevated. The patient had a past history of sarcoidosis of the eyes and lungs 22 years previously. Cardiac diseases presenting epithelioid cells other than sarcoidosis were clinically ruled out. Thus, the diagnosis of cardic sarcoidosis was made based on both clinical and ultrastructural findings, and corticosteroid therapy was initiated. In the second biopsy, performed 4 months later, a noncaseating granuloma was found. Generally, the incidence of histological diagnosis of cardiac sarcoidosis by light microscopy is relatively low in endomyocardial biopsy specimens. The present case suggests that the addition of an ultrastructural examination may improve the diagnostic usefulness of the endomyocardial biopsy in cardiac sarcoidosis, since electron microscopy can clearly identify the presence of even one epithelioid cell. More... »

PAGES

275-278

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01744907

DOI

http://dx.doi.org/10.1007/bf01744907

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042180494

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8904003


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197 rdf:type schema:Organization
198 grid-institutes:grid.413697.e schema:alternateName The Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsu-cho, Amagasaki-shi, 660, Hyogo, Japan
199 schema:name The Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsu-cho, Amagasaki-shi, 660, Hyogo, Japan
200 rdf:type schema:Organization
 




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