Induction of T-cell-mediated immunity against MethA fibrosarcoma by intratumoral injections of a bacillus Calmette-Guérin nucleic acid fraction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-09

AUTHORS

Etsuro Kuramoto, Osamu Yano, Shizuo Shimada

ABSTRACT

MY-1, which consists of DNA and RNA extracted and purified from bacillus Calmette-Guérin (BCG), has been shown to have strong antitumor activity against various experimental tumors. To examine the role of T cells in the antitumor mechanism of MY-1, the effect of MY-1 injection on the development of tumor-specific immunity against MethA fibrosarcoma was investigated. MY-1 injections inhibited tumor growth less effectively in T-cell-deficient nude mice than in normal BALB/c mice. MethA tumor growth was suppressed after inoculation with L3T4-positive lymphocytes from tumor-bearing mice treated with MY-1. MethA-specific delayed-type hypersensitivity was also detected in tumor-bearing mice treated with MY-1. Immunohistochemical analyses showed that many L3T4-positive and a few Lyt2-positive cells infiltrated the regressing tumors. These results indicate that intratumoral MY-1 injections induce a MethA-specific, L3T4-positive cell-mediated, delayed-type hypersensitivity, which is necessary for the tumor regression. More... »

PAGES

283-288

References to SciGraph publications

Journal

TITLE

Cancer Immunology, Immunotherapy

ISSUE

5

VOLUME

34

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01741547

    DOI

    http://dx.doi.org/10.1007/bf01741547

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015303238

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1371719


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