Clonidine normalizes low plasmaβ-endorphin concentration and blood pressure in young men with mild essential hypertension View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-08

AUTHORS

K. Kraft, R. Theobald, K. O. Stumpe

ABSTRACT

In young men with mild essential hypertension and age-matched normotensive volunteers, plasma concentrations of the endogenous opioid beta-endorphin were determined hourly from 9:00 p.m. to 2:00 a.m. The hypertensive patients' mean plasma beta-endorphin concentration was significantly lower in comparison with normotensive controls. After 14 days of treatment with clonidine, systolic and diastolic blood pressure was significantly reduced in both groups. Plasma beta-endorphin concentration increased in the hypertensive patients, but remained unchanged in the normotensive volunteers. The present findings point to a possible involvement of reduced beta-endorphinergic activity in blood pressure regulation of young men with essential hypertension. More... »

PAGES

738-741

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01734340

DOI

http://dx.doi.org/10.1007/bf01734340

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017866083

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2945042


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