Neuere Aspekte zur Pathogenese endokriner Autoimmunerkrankungen des Menschen: Welche Rolle spielt die Expression von HLA Klasse-II-Molekülen durch die endokrine Zielzelle? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-11

AUTHORS

U. Deuß, M. Buscema, G. F. Bottazzo, W. Winkelmann

ABSTRACT

The inappropriate expression of HLA Class II molecules by the target cells of endocrine autoimmune diseases is a recent observation that has been intensively studied in thyroid autoimmunity and type I diabetes mellitus. In vitro studies have shown that interferon-gamma can induce Class II expression, either alone, as in thyrocytes, or in combination with other mediators like tumour necrosis factor or lymphotoxin, as in islet cells, pointing to possible mechanisms operating in vivo. Endocrine cells expressing Class II molecules are able to present their autoantigens to helper T cells, thus possibly inducing the autoimmune process. However, until now it is still unclear if the expression of Class II molecules by the target cells is the primary immune phenomenon, which might possibly be triggered by a latent viral infection of the endocrine cell. Alternatively, it might be a secondary response in an ongoing autoimmune process. Particularly data obtained in the diabetic pancreas favour the first possibility, but only progress in our understanding of the role of HLA antigens in immunoregulation will make it possible to interpret the phenomenon properly. More... »

PAGES

1117-1125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01726112

DOI

http://dx.doi.org/10.1007/bf01726112

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022202897

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2685454


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocrine Glands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocrine System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Lungenklinik K\u00f6ln-Merheim", 
          "id": "https://www.grid.ac/institutes/grid.491990.c", 
          "name": [
            "Medizinische Universit\u00e4tsklinik II, Krankenhaus K\u00f6ln-Merheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deu\u00df", 
        "givenName": "U.", 
        "id": "sg:person.0577710773.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577710773.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, University College and Middlesex School of Medicine, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buscema", 
        "givenName": "M.", 
        "id": "sg:person.0667262667.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667262667.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, University College and Middlesex School of Medicine, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bottazzo", 
        "givenName": "G. F.", 
        "id": "sg:person.0723572726.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lungenklinik K\u00f6ln-Merheim", 
          "id": "https://www.grid.ac/institutes/grid.491990.c", 
          "name": [
            "Medizinische Universit\u00e4tsklinik II, Krankenhaus K\u00f6ln-Merheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winkelmann", 
        "givenName": "W.", 
        "id": "sg:person.01013277103.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013277103.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0167-5699(82)90019-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002430825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326304a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006495811", 
          "https://doi.org/10.1038/326304a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(85)80446-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006801392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90414-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011620206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/251547a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013519329", 
          "https://doi.org/10.1038/251547a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/251547a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013519329", 
          "https://doi.org/10.1038/251547a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.293.6555.1132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014791525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90497-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016337935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90327-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018810104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)90327-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018810104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312639a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022396706", 
          "https://doi.org/10.1038/312639a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.1990.tb08093.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022579057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198101000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026595193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198101000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026595193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/304071a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027273443", 
          "https://doi.org/10.1038/304071a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610030311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028819483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dmr.5610030311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028819483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(81)92795-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034534271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-198705000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035065279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-198705000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035065279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(85)90085-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036331181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(83)90628-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037339513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)91108-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037800350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(84)91108-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037800350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198508083130604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043991775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(85)90036-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044745252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00299027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045676074", 
          "https://doi.org/10.1007/bf00299027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00299027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045676074", 
          "https://doi.org/10.1007/bf00299027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329512a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046078048", 
          "https://doi.org/10.1038/329512a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(83)90629-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048346040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.27.2.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048647118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(87)90845-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049755783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(87)90845-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049755783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198504253121706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050989989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325265a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053290216", 
          "https://doi.org/10.1038/325265a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3368786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062609753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3458307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062615218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3726548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3871967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062622030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-61-3-418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064313948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-61-5-817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064314019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-63-5-1086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064314484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-66-2-367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064315045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-69-2-433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064315725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.35.11.1215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070734928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.35.11.1215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070740758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079549880", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079554230", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079563859", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647136", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079680274", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079681745", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079856294", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080012040", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080012113", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080026967", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080039900", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081576257", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081615106", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081638171", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081835486", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-11", 
    "datePublishedReg": "1989-11-01", 
    "description": "The inappropriate expression of HLA Class II molecules by the target cells of endocrine autoimmune diseases is a recent observation that has been intensively studied in thyroid autoimmunity and type I diabetes mellitus. In vitro studies have shown that interferon-gamma can induce Class II expression, either alone, as in thyrocytes, or in combination with other mediators like tumour necrosis factor or lymphotoxin, as in islet cells, pointing to possible mechanisms operating in vivo. Endocrine cells expressing Class II molecules are able to present their autoantigens to helper T cells, thus possibly inducing the autoimmune process. However, until now it is still unclear if the expression of Class II molecules by the target cells is the primary immune phenomenon, which might possibly be triggered by a latent viral infection of the endocrine cell. Alternatively, it might be a secondary response in an ongoing autoimmune process. Particularly data obtained in the diabetic pancreas favour the first possibility, but only progress in our understanding of the role of HLA antigens in immunoregulation will make it possible to interpret the phenomenon properly.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01726112", 
    "inLanguage": [
      "de"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1057918", 
        "issn": [
          "0946-2716", 
          "1432-1440"
        ], 
        "name": "Journal of Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "22", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "name": "Neuere Aspekte zur Pathogenese endokriner Autoimmunerkrankungen des Menschen: Welche Rolle spielt die Expression von HLA Klasse-II-Molek\u00fclen durch die endokrine Zielzelle?", 
    "pagination": "1117-1125", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "69c7f0f895d24f5d16f2142f8112b2b193fdf8bbae5a96239fda3dcf12ca9f9f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2685454"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "2985205R"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01726112"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022202897"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01726112", 
      "https://app.dimensions.ai/details/publication/pub.1022202897"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99832_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01726112"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01726112'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01726112'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01726112'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01726112'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      88 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01726112 schema:about N4649b34a97ea46f89cba55341c6247ca
2 N5382543639124016aea77dc2f0ed747e
3 N6c32ee89f7d34d4284955cf06b6ab35e
4 N7ba8f545fdd94e24bcb6a7096540c16c
5 Ncf16244890494bc38d66e3787ba2dbf1
6 Nd102a406c30f4d458324980ca3755989
7 anzsrc-for:11
8 anzsrc-for:1107
9 schema:author Nf480423020d842bf9b079fc5308b72ba
10 schema:citation sg:pub.10.1007/bf00299027
11 sg:pub.10.1038/251547a0
12 sg:pub.10.1038/304071a0
13 sg:pub.10.1038/312639a0
14 sg:pub.10.1038/325265a0
15 sg:pub.10.1038/326304a0
16 sg:pub.10.1038/329512a0
17 https://app.dimensions.ai/details/publication/pub.1079549880
18 https://app.dimensions.ai/details/publication/pub.1079554230
19 https://app.dimensions.ai/details/publication/pub.1079563859
20 https://app.dimensions.ai/details/publication/pub.1079647136
21 https://app.dimensions.ai/details/publication/pub.1079680274
22 https://app.dimensions.ai/details/publication/pub.1079681745
23 https://app.dimensions.ai/details/publication/pub.1079856294
24 https://app.dimensions.ai/details/publication/pub.1080012040
25 https://app.dimensions.ai/details/publication/pub.1080012113
26 https://app.dimensions.ai/details/publication/pub.1080026967
27 https://app.dimensions.ai/details/publication/pub.1080039900
28 https://app.dimensions.ai/details/publication/pub.1081576257
29 https://app.dimensions.ai/details/publication/pub.1081615106
30 https://app.dimensions.ai/details/publication/pub.1081638171
31 https://app.dimensions.ai/details/publication/pub.1081835486
32 https://doi.org/10.1002/dmr.5610030311
33 https://doi.org/10.1016/0008-8749(85)90036-x
34 https://doi.org/10.1016/0014-5793(85)80446-4
35 https://doi.org/10.1016/0092-8674(88)90414-x
36 https://doi.org/10.1016/0092-8674(88)90497-7
37 https://doi.org/10.1016/0167-5699(82)90019-6
38 https://doi.org/10.1016/0167-5699(85)90085-4
39 https://doi.org/10.1016/0167-5699(87)90845-0
40 https://doi.org/10.1016/s0140-6736(81)92795-1
41 https://doi.org/10.1016/s0140-6736(83)90628-1
42 https://doi.org/10.1016/s0140-6736(83)90629-3
43 https://doi.org/10.1016/s0140-6736(84)90327-1
44 https://doi.org/10.1016/s0140-6736(84)91108-5
45 https://doi.org/10.1056/nejm198504253121706
46 https://doi.org/10.1056/nejm198508083130604
47 https://doi.org/10.1097/00006676-198705000-00016
48 https://doi.org/10.1097/00007890-198101000-00017
49 https://doi.org/10.1111/j.1365-2249.1990.tb08093.x
50 https://doi.org/10.1126/science.3368786
51 https://doi.org/10.1126/science.3458307
52 https://doi.org/10.1126/science.3726548
53 https://doi.org/10.1126/science.3871967
54 https://doi.org/10.1136/bmj.293.6555.1132
55 https://doi.org/10.1136/gut.27.2.153
56 https://doi.org/10.1210/jcem-61-3-418
57 https://doi.org/10.1210/jcem-61-5-817
58 https://doi.org/10.1210/jcem-63-5-1086
59 https://doi.org/10.1210/jcem-66-2-367
60 https://doi.org/10.1210/jcem-69-2-433
61 https://doi.org/10.2337/diab.35.11.1215
62 https://doi.org/10.2337/diabetes.35.11.1215
63 schema:datePublished 1989-11
64 schema:datePublishedReg 1989-11-01
65 schema:description The inappropriate expression of HLA Class II molecules by the target cells of endocrine autoimmune diseases is a recent observation that has been intensively studied in thyroid autoimmunity and type I diabetes mellitus. In vitro studies have shown that interferon-gamma can induce Class II expression, either alone, as in thyrocytes, or in combination with other mediators like tumour necrosis factor or lymphotoxin, as in islet cells, pointing to possible mechanisms operating in vivo. Endocrine cells expressing Class II molecules are able to present their autoantigens to helper T cells, thus possibly inducing the autoimmune process. However, until now it is still unclear if the expression of Class II molecules by the target cells is the primary immune phenomenon, which might possibly be triggered by a latent viral infection of the endocrine cell. Alternatively, it might be a secondary response in an ongoing autoimmune process. Particularly data obtained in the diabetic pancreas favour the first possibility, but only progress in our understanding of the role of HLA antigens in immunoregulation will make it possible to interpret the phenomenon properly.
66 schema:genre research_article
67 schema:inLanguage de
68 schema:isAccessibleForFree false
69 schema:isPartOf N340f98939f6f47f28d38992dc00763bd
70 N8feca93a4f8442628bd60d8ecbf6179d
71 sg:journal.1057918
72 schema:name Neuere Aspekte zur Pathogenese endokriner Autoimmunerkrankungen des Menschen: Welche Rolle spielt die Expression von HLA Klasse-II-Molekülen durch die endokrine Zielzelle?
73 schema:pagination 1117-1125
74 schema:productId N2ed2f54bdfa946669ebb350fb3f2b3b7
75 N38ba19661ae54d12851f6db3e04ba773
76 Nc25f8ce273644ea8840f702d4fc3cc41
77 Nc28d7a5e712b47489661ee6d2d136cd2
78 Nc2b1346fef2c4768bfbf4534392d0303
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022202897
80 https://doi.org/10.1007/bf01726112
81 schema:sdDatePublished 2019-04-11T09:38
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N11ff4a47494f422a8c071c3c0cc9d275
84 schema:url http://link.springer.com/10.1007/BF01726112
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N0401c3e415f44a0cbbdb182f3ff5bf09 rdf:first sg:person.0723572726.20
89 rdf:rest N57752c5b86bb427ea8c1805bcca13250
90 N11ff4a47494f422a8c071c3c0cc9d275 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N2937f960e4cd45869c8d5af70debed2c schema:name Department of Immunology, University College and Middlesex School of Medicine, London, UK
93 rdf:type schema:Organization
94 N2ed2f54bdfa946669ebb350fb3f2b3b7 schema:name doi
95 schema:value 10.1007/bf01726112
96 rdf:type schema:PropertyValue
97 N340f98939f6f47f28d38992dc00763bd schema:issueNumber 22
98 rdf:type schema:PublicationIssue
99 N38ba19661ae54d12851f6db3e04ba773 schema:name readcube_id
100 schema:value 69c7f0f895d24f5d16f2142f8112b2b193fdf8bbae5a96239fda3dcf12ca9f9f
101 rdf:type schema:PropertyValue
102 N4649b34a97ea46f89cba55341c6247ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Endocrine Glands
104 rdf:type schema:DefinedTerm
105 N5382543639124016aea77dc2f0ed747e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N57752c5b86bb427ea8c1805bcca13250 rdf:first sg:person.01013277103.05
109 rdf:rest rdf:nil
110 N6c32ee89f7d34d4284955cf06b6ab35e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Endocrine System Diseases
112 rdf:type schema:DefinedTerm
113 N79f786258498453ca1c11d88f865ebd8 rdf:first sg:person.0667262667.07
114 rdf:rest N0401c3e415f44a0cbbdb182f3ff5bf09
115 N7ba8f545fdd94e24bcb6a7096540c16c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Gene Expression
117 rdf:type schema:DefinedTerm
118 N8feca93a4f8442628bd60d8ecbf6179d schema:volumeNumber 67
119 rdf:type schema:PublicationVolume
120 Nb359e60f54e64977bcd96a1d3c2ba308 schema:name Department of Immunology, University College and Middlesex School of Medicine, London, UK
121 rdf:type schema:Organization
122 Nc25f8ce273644ea8840f702d4fc3cc41 schema:name nlm_unique_id
123 schema:value 2985205R
124 rdf:type schema:PropertyValue
125 Nc28d7a5e712b47489661ee6d2d136cd2 schema:name dimensions_id
126 schema:value pub.1022202897
127 rdf:type schema:PropertyValue
128 Nc2b1346fef2c4768bfbf4534392d0303 schema:name pubmed_id
129 schema:value 2685454
130 rdf:type schema:PropertyValue
131 Ncf16244890494bc38d66e3787ba2dbf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Autoimmune Diseases
133 rdf:type schema:DefinedTerm
134 Nd102a406c30f4d458324980ca3755989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Histocompatibility Antigens Class II
136 rdf:type schema:DefinedTerm
137 Nf480423020d842bf9b079fc5308b72ba rdf:first sg:person.0577710773.48
138 rdf:rest N79f786258498453ca1c11d88f865ebd8
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
143 schema:name Immunology
144 rdf:type schema:DefinedTerm
145 sg:journal.1057918 schema:issn 0946-2716
146 1432-1440
147 schema:name Journal of Molecular Medicine
148 rdf:type schema:Periodical
149 sg:person.01013277103.05 schema:affiliation https://www.grid.ac/institutes/grid.491990.c
150 schema:familyName Winkelmann
151 schema:givenName W.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013277103.05
153 rdf:type schema:Person
154 sg:person.0577710773.48 schema:affiliation https://www.grid.ac/institutes/grid.491990.c
155 schema:familyName Deuß
156 schema:givenName U.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577710773.48
158 rdf:type schema:Person
159 sg:person.0667262667.07 schema:affiliation N2937f960e4cd45869c8d5af70debed2c
160 schema:familyName Buscema
161 schema:givenName M.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667262667.07
163 rdf:type schema:Person
164 sg:person.0723572726.20 schema:affiliation Nb359e60f54e64977bcd96a1d3c2ba308
165 schema:familyName Bottazzo
166 schema:givenName G. F.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20
168 rdf:type schema:Person
169 sg:pub.10.1007/bf00299027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045676074
170 https://doi.org/10.1007/bf00299027
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/251547a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013519329
173 https://doi.org/10.1038/251547a0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/304071a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027273443
176 https://doi.org/10.1038/304071a0
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/312639a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022396706
179 https://doi.org/10.1038/312639a0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/325265a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053290216
182 https://doi.org/10.1038/325265a0
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/326304a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006495811
185 https://doi.org/10.1038/326304a0
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/329512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046078048
188 https://doi.org/10.1038/329512a0
189 rdf:type schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1079549880 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1079554230 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1079563859 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079647136 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1079680274 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1079681745 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1079856294 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1080012040 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1080012113 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1080026967 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1080039900 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1081576257 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1081615106 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1081638171 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1081835486 schema:CreativeWork
205 https://doi.org/10.1002/dmr.5610030311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028819483
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0008-8749(85)90036-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044745252
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0014-5793(85)80446-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006801392
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0092-8674(88)90414-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011620206
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0092-8674(88)90497-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016337935
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0167-5699(82)90019-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002430825
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0167-5699(85)90085-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036331181
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0167-5699(87)90845-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049755783
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0140-6736(81)92795-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034534271
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0140-6736(83)90628-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037339513
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0140-6736(83)90629-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048346040
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0140-6736(84)90327-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018810104
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0140-6736(84)91108-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037800350
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1056/nejm198504253121706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050989989
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1056/nejm198508083130604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043991775
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/00006676-198705000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035065279
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/00007890-198101000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026595193
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1365-2249.1990.tb08093.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579057
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1126/science.3368786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062609753
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1126/science.3458307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062615218
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1126/science.3726548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621299
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1126/science.3871967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062622030
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1136/bmj.293.6555.1132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014791525
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1136/gut.27.2.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048647118
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1210/jcem-61-3-418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064313948
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1210/jcem-61-5-817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064314019
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1210/jcem-63-5-1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064314484
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1210/jcem-66-2-367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064315045
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1210/jcem-69-2-433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064315725
262 rdf:type schema:CreativeWork
263 https://doi.org/10.2337/diab.35.11.1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070734928
264 rdf:type schema:CreativeWork
265 https://doi.org/10.2337/diabetes.35.11.1215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070740758
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.491990.c schema:alternateName Lungenklinik Köln-Merheim
268 schema:name Medizinische Universitätsklinik II, Krankenhaus Köln-Merheim, Germany
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...