Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-06

AUTHORS

G. Visani, M. Fogli, P. Tosi, E. Ottaviani, B. Gamberi, A. Cenacchi, S. Manfroi, S. Tura

ABSTRACT

R-Verapamil (R-VPM), an enantiomer of racemic verapamil (VPM), has been recently reported to possess an activity equivalent to VPM in reverting drug resistance in vitro, without showing remarkable cardiovascular toxicity in animal models, even in doses three times higher than VPM. In this study, we assessed the effects of R-VPM in vitro, on clonogenic leukemia cells (CFU-L) from 15 patients with acute nonlymphoid leukemia (ANLL) at diagnosis, and on bone marrow erythroid (BFU-E) and myeloid (CFU-GM) progenitors from 15 healthy volunteers. On CFU-L, continuous exposure to VPM or R-VPM alone showed a slight inhibitory activity; in combination with daunorubicin (DNR), R-VPM proved more effective (mean IC50 of DNR: alone = 24.53 ng/ml +/- 6.2 SE, + VPM = 18.8 ng/ml +/- 4.6 SE, +R-VPM = 17.9 ng/ml +/- 4.8 SE). On CFU-GM, both VPM and R-VPM were minimally toxic at the lowest concentration used, but 30 microM VPM were significantly more toxic than R-VPM at the same dose (residual growth = 39.2% +/- 6.5% vs. 71.8% +/- 9.3% with R-VPM, p = 0.005). On BFU-E, both VPM and R-VPM caused more consistent growth inhibition; at high doses, VPM was again more toxic than R-VPM (33.4% +/- 12.8% vs 53.4% +/- 10.4% residual growth at 30 microM, p = 0.03). DNR toxicity on bone marrow was more greatly enhanced by VPM than R-VPM, and this difference was statistically significant on erythroid progenitor colony growth (p = 0.04). In conclusion, in comparison to VPM, R-VPM appeared to be at least equally effective on leukemic clonogenic cells and less toxic on normal bone marrow precursors, thus suggesting a possible safe use in vivo, even in concentrations that cannot be achieved with VPM, owing to its toxic effects. More... »

PAGES

273-276

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01695968

DOI

http://dx.doi.org/10.1007/bf01695968

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022572997

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8318558


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colony-Forming Units Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Daunorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythroid Precursor Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stereoisomerism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Stem Cell Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Verapamil", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Visani", 
        "givenName": "G.", 
        "id": "sg:person.01120176017.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120176017.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fogli", 
        "givenName": "M.", 
        "id": "sg:person.0660255155.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660255155.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tosi", 
        "givenName": "P.", 
        "id": "sg:person.0750007462.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750007462.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ottaviani", 
        "givenName": "E.", 
        "id": "sg:person.0614725555.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614725555.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gamberi", 
        "givenName": "B.", 
        "id": "sg:person.01106553212.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106553212.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cenacchi", 
        "givenName": "A.", 
        "id": "sg:person.01154666412.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154666412.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manfroi", 
        "givenName": "S.", 
        "id": "sg:person.01132271706.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132271706.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology \u201cL. e A. Seragnoli\u201d, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tura", 
        "givenName": "S.", 
        "id": "sg:person.01076600343.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076600343.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0277-5379(90)90159-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.2950130408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005706633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0145-2126(90)90025-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011605982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(87)90306-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014422822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198608000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016763040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-198608000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016763040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00255285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017814352", 
          "https://doi.org/10.1007/bf00255285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00255285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017814352", 
          "https://doi.org/10.1007/bf00255285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1988.tb06190.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035155504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1988.tb00846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038048066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1988.tb00846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038048066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90141-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042233556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075948159", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077254441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077670169", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078251074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078997122", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079435632", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079648557", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079998602", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081992357", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-06", 
    "datePublishedReg": "1993-06-01", 
    "description": "R-Verapamil (R-VPM), an enantiomer of racemic verapamil (VPM), has been recently reported to possess an activity equivalent to VPM in reverting drug resistance in vitro, without showing remarkable cardiovascular toxicity in animal models, even in doses three times higher than VPM. In this study, we assessed the effects of R-VPM in vitro, on clonogenic leukemia cells (CFU-L) from 15 patients with acute nonlymphoid leukemia (ANLL) at diagnosis, and on bone marrow erythroid (BFU-E) and myeloid (CFU-GM) progenitors from 15 healthy volunteers. On CFU-L, continuous exposure to VPM or R-VPM alone showed a slight inhibitory activity; in combination with daunorubicin (DNR), R-VPM proved more effective (mean IC50 of DNR: alone = 24.53 ng/ml +/- 6.2 SE, + VPM = 18.8 ng/ml +/- 4.6 SE, +R-VPM = 17.9 ng/ml +/- 4.8 SE). On CFU-GM, both VPM and R-VPM were minimally toxic at the lowest concentration used, but 30 microM VPM were significantly more toxic than R-VPM at the same dose (residual growth = 39.2% +/- 6.5% vs. 71.8% +/- 9.3% with R-VPM, p = 0.005). On BFU-E, both VPM and R-VPM caused more consistent growth inhibition; at high doses, VPM was again more toxic than R-VPM (33.4% +/- 12.8% vs 53.4% +/- 10.4% residual growth at 30 microM, p = 0.03). DNR toxicity on bone marrow was more greatly enhanced by VPM than R-VPM, and this difference was statistically significant on erythroid progenitor colony growth (p = 0.04). In conclusion, in comparison to VPM, R-VPM appeared to be at least equally effective on leukemic clonogenic cells and less toxic on normal bone marrow precursors, thus suggesting a possible safe use in vivo, even in concentrations that cannot be achieved with VPM, owing to its toxic effects.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01695968", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018247", 
        "issn": [
          "1269-3286", 
          "1279-8509"
        ], 
        "name": "Annals of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "66"
      }
    ], 
    "name": "Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors", 
    "pagination": "273-276", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6b8add52013634d34f5442a53fa7b841c2591c9ae01c66dc80cb1fc927d14a90"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8318558"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9107334"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01695968"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022572997"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01695968", 
      "https://app.dimensions.ai/details/publication/pub.1022572997"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46744_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01695968"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01695968'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01695968'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01695968'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01695968'


 

This table displays all metadata directly associated to this object as RDF triples.

212 TRIPLES      21 PREDICATES      59 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01695968 schema:about N002a76ea4b254da686bb6fed8303afc7
2 N01055df380df49c88e45524385286449
3 N06c6f7077e1c44ea84cf4de4a2c6d107
4 N0fe58b0e9a2c48048bac4b148b89a77e
5 N2890e29109dd4f9ab4dca81de6d0feb3
6 N44da3f0062e642ed81bb26580a211253
7 N4d94bb0dc9e04fcb9120e62395f05de5
8 N68520750914b4f2893a8ff600d475e5d
9 N71ddecddbf8c4328adf837a3934d1270
10 Na2844878ad49459a8a07e75e0973d42c
11 Nb9661bb6429f4cb0b1f17800b7fa6870
12 Nce734f6236bc4707bbda36a506d43465
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Nda71e8a6affc4efb9bb7cc4652e982f6
16 schema:citation sg:pub.10.1007/bf00255285
17 https://app.dimensions.ai/details/publication/pub.1075948159
18 https://app.dimensions.ai/details/publication/pub.1077254441
19 https://app.dimensions.ai/details/publication/pub.1077670169
20 https://app.dimensions.ai/details/publication/pub.1078251074
21 https://app.dimensions.ai/details/publication/pub.1078997122
22 https://app.dimensions.ai/details/publication/pub.1079435632
23 https://app.dimensions.ai/details/publication/pub.1079648557
24 https://app.dimensions.ai/details/publication/pub.1079998602
25 https://app.dimensions.ai/details/publication/pub.1081992357
26 https://doi.org/10.1002/mpo.2950130408
27 https://doi.org/10.1016/0014-4827(87)90306-5
28 https://doi.org/10.1016/0092-8674(91)90141-k
29 https://doi.org/10.1016/0145-2126(90)90025-5
30 https://doi.org/10.1016/0277-5379(90)90159-q
31 https://doi.org/10.1097/00000421-198608000-00016
32 https://doi.org/10.1111/j.1365-2141.1988.tb06190.x
33 https://doi.org/10.1111/j.1600-0609.1988.tb00846.x
34 schema:datePublished 1993-06
35 schema:datePublishedReg 1993-06-01
36 schema:description R-Verapamil (R-VPM), an enantiomer of racemic verapamil (VPM), has been recently reported to possess an activity equivalent to VPM in reverting drug resistance in vitro, without showing remarkable cardiovascular toxicity in animal models, even in doses three times higher than VPM. In this study, we assessed the effects of R-VPM in vitro, on clonogenic leukemia cells (CFU-L) from 15 patients with acute nonlymphoid leukemia (ANLL) at diagnosis, and on bone marrow erythroid (BFU-E) and myeloid (CFU-GM) progenitors from 15 healthy volunteers. On CFU-L, continuous exposure to VPM or R-VPM alone showed a slight inhibitory activity; in combination with daunorubicin (DNR), R-VPM proved more effective (mean IC50 of DNR: alone = 24.53 ng/ml +/- 6.2 SE, + VPM = 18.8 ng/ml +/- 4.6 SE, +R-VPM = 17.9 ng/ml +/- 4.8 SE). On CFU-GM, both VPM and R-VPM were minimally toxic at the lowest concentration used, but 30 microM VPM were significantly more toxic than R-VPM at the same dose (residual growth = 39.2% +/- 6.5% vs. 71.8% +/- 9.3% with R-VPM, p = 0.005). On BFU-E, both VPM and R-VPM caused more consistent growth inhibition; at high doses, VPM was again more toxic than R-VPM (33.4% +/- 12.8% vs 53.4% +/- 10.4% residual growth at 30 microM, p = 0.03). DNR toxicity on bone marrow was more greatly enhanced by VPM than R-VPM, and this difference was statistically significant on erythroid progenitor colony growth (p = 0.04). In conclusion, in comparison to VPM, R-VPM appeared to be at least equally effective on leukemic clonogenic cells and less toxic on normal bone marrow precursors, thus suggesting a possible safe use in vivo, even in concentrations that cannot be achieved with VPM, owing to its toxic effects.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N5ac9ea7b6d744e3e8ce9b8a2a03d739d
41 Nb4ccb6be92154442b5d5e2ad3a4959c9
42 sg:journal.1018247
43 schema:name Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors
44 schema:pagination 273-276
45 schema:productId N399ad2807d3f44a59a53005fd5b55f04
46 N4b1554bbb3a94a95af6c9b06812660f4
47 N6453054e96b64c168fc13121d379686f
48 Ndf982a1641124b5bbf3ed25bc4fc0e46
49 Nff6acd7780c34d6fba4636d642a05e2f
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022572997
51 https://doi.org/10.1007/bf01695968
52 schema:sdDatePublished 2019-04-11T13:28
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N10c55e24550c476bbb7c132721d04032
55 schema:url http://link.springer.com/10.1007/BF01695968
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N002a76ea4b254da686bb6fed8303afc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Colony-Forming Units Assay
61 rdf:type schema:DefinedTerm
62 N01055df380df49c88e45524385286449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Bone Marrow Cells
64 rdf:type schema:DefinedTerm
65 N06b99a75a1ee4cf5b1c654b4abe9cf15 rdf:first sg:person.01076600343.09
66 rdf:rest rdf:nil
67 N06c6f7077e1c44ea84cf4de4a2c6d107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Stem Cells
69 rdf:type schema:DefinedTerm
70 N0fe58b0e9a2c48048bac4b148b89a77e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Stereoisomerism
72 rdf:type schema:DefinedTerm
73 N10c55e24550c476bbb7c132721d04032 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N2890e29109dd4f9ab4dca81de6d0feb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Daunorubicin
77 rdf:type schema:DefinedTerm
78 N399ad2807d3f44a59a53005fd5b55f04 schema:name dimensions_id
79 schema:value pub.1022572997
80 rdf:type schema:PropertyValue
81 N44da3f0062e642ed81bb26580a211253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Tumor Stem Cell Assay
83 rdf:type schema:DefinedTerm
84 N493672c18e984cc9bce9016f3e271bbf rdf:first sg:person.01154666412.54
85 rdf:rest N7c4aaf0367a149a0a842789f367fb009
86 N4adb8408130f42568984a565f954a249 rdf:first sg:person.0614725555.14
87 rdf:rest N84448cddacdd48cab50ffdb0fcb5ac1f
88 N4b1554bbb3a94a95af6c9b06812660f4 schema:name readcube_id
89 schema:value 6b8add52013634d34f5442a53fa7b841c2591c9ae01c66dc80cb1fc927d14a90
90 rdf:type schema:PropertyValue
91 N4d94bb0dc9e04fcb9120e62395f05de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Verapamil
93 rdf:type schema:DefinedTerm
94 N5ac9ea7b6d744e3e8ce9b8a2a03d739d schema:issueNumber 6
95 rdf:type schema:PublicationIssue
96 N6453054e96b64c168fc13121d379686f schema:name pubmed_id
97 schema:value 8318558
98 rdf:type schema:PropertyValue
99 N68520750914b4f2893a8ff600d475e5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Erythroid Precursor Cells
101 rdf:type schema:DefinedTerm
102 N71ddecddbf8c4328adf837a3934d1270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Leukemia
104 rdf:type schema:DefinedTerm
105 N7c4aaf0367a149a0a842789f367fb009 rdf:first sg:person.01132271706.06
106 rdf:rest N06b99a75a1ee4cf5b1c654b4abe9cf15
107 N84448cddacdd48cab50ffdb0fcb5ac1f rdf:first sg:person.01106553212.47
108 rdf:rest N493672c18e984cc9bce9016f3e271bbf
109 N9743cf7edab34adaad91f6c3c7964a53 rdf:first sg:person.0750007462.30
110 rdf:rest N4adb8408130f42568984a565f954a249
111 Na2844878ad49459a8a07e75e0973d42c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Leukemia, Myeloid, Acute
113 rdf:type schema:DefinedTerm
114 Nb4ccb6be92154442b5d5e2ad3a4959c9 schema:volumeNumber 66
115 rdf:type schema:PublicationVolume
116 Nb9661bb6429f4cb0b1f17800b7fa6870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 Nce734f6236bc4707bbda36a506d43465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Drug Therapy, Combination
121 rdf:type schema:DefinedTerm
122 Nda71e8a6affc4efb9bb7cc4652e982f6 rdf:first sg:person.01120176017.40
123 rdf:rest Nde89b68dd6f54d97b382aa182b3eb018
124 Nde89b68dd6f54d97b382aa182b3eb018 rdf:first sg:person.0660255155.82
125 rdf:rest N9743cf7edab34adaad91f6c3c7964a53
126 Ndf982a1641124b5bbf3ed25bc4fc0e46 schema:name nlm_unique_id
127 schema:value 9107334
128 rdf:type schema:PropertyValue
129 Nff6acd7780c34d6fba4636d642a05e2f schema:name doi
130 schema:value 10.1007/bf01695968
131 rdf:type schema:PropertyValue
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
136 schema:name Cardiorespiratory Medicine and Haematology
137 rdf:type schema:DefinedTerm
138 sg:journal.1018247 schema:issn 1269-3286
139 1279-8509
140 schema:name Annals of Hematology
141 rdf:type schema:Periodical
142 sg:person.01076600343.09 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
143 schema:familyName Tura
144 schema:givenName S.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076600343.09
146 rdf:type schema:Person
147 sg:person.01106553212.47 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
148 schema:familyName Gamberi
149 schema:givenName B.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106553212.47
151 rdf:type schema:Person
152 sg:person.01120176017.40 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
153 schema:familyName Visani
154 schema:givenName G.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120176017.40
156 rdf:type schema:Person
157 sg:person.01132271706.06 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
158 schema:familyName Manfroi
159 schema:givenName S.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132271706.06
161 rdf:type schema:Person
162 sg:person.01154666412.54 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
163 schema:familyName Cenacchi
164 schema:givenName A.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154666412.54
166 rdf:type schema:Person
167 sg:person.0614725555.14 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
168 schema:familyName Ottaviani
169 schema:givenName E.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614725555.14
171 rdf:type schema:Person
172 sg:person.0660255155.82 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
173 schema:familyName Fogli
174 schema:givenName M.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660255155.82
176 rdf:type schema:Person
177 sg:person.0750007462.30 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
178 schema:familyName Tosi
179 schema:givenName P.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750007462.30
181 rdf:type schema:Person
182 sg:pub.10.1007/bf00255285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017814352
183 https://doi.org/10.1007/bf00255285
184 rdf:type schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1075948159 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1077254441 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1077670169 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1078251074 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1078997122 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1079435632 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1079648557 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1079998602 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1081992357 schema:CreativeWork
194 https://doi.org/10.1002/mpo.2950130408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005706633
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0014-4827(87)90306-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014422822
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0092-8674(91)90141-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1042233556
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0145-2126(90)90025-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011605982
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0277-5379(90)90159-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1004208118
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00000421-198608000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016763040
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1365-2141.1988.tb06190.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035155504
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1600-0609.1988.tb00846.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038048066
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.6292.f schema:alternateName University of Bologna
211 schema:name Institute of Hematology “L. e A. Seragnoli”, University of Bologna, Bologna, Italy
212 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...