Stimulation ofin vitro proliferation of murine lymphocytes by synthetic oligodeoxynucleotides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-10

AUTHORS

David S. Pisetsky, Charles Reich

ABSTRACT

To elucidate the properties of mitogenic nucleic acids, the ability of oligodeoxynucleotides to stimulate thein vitro proliferation of murine lymphocytes was investigated. The compounds tested were a series of oligodeoxynucleotides, synthesized with either phosphodiester or phosphorothioate chemistry and containing (dG) and (dC) alone or together. Among oligodeoxynucleotides tested, phosphorothioates were more active than phosphodiesters and stimulated thymidine incorporation under the same conditions as mitogenic non-mammalian DNA, Mitogenesis was unaffected by depletion of T cells, suggesting B cells as the predominant cell type stimulated. These results indicate that mitogenic nucleic acids need not have an extended polymeric structure and raise the possibility that antisense compounds have immunologic activity, at least in animal models. More... »

PAGES

217-221

Journal

TITLE

Molecular Biology Reports

ISSUE

3

VOLUME

18

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01674433

    DOI

    http://dx.doi.org/10.1007/bf01674433

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004877232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8114689


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