Ontology type: schema:ScholarlyArticle
1981-07
AUTHORSPeter Langhans, Ralph A. Heger, J. Hohenstein, Werner Schlake, Hermann Bünte
ABSTRACTSeveral etiopathogenetic factors responsible for carcinogenesis in the operated stomach have been proposed in the literature, but exact proof is still lacking. An experimental assay was planned to determine the pathogenetic roles of surgical trauma, of duodenogastric reflux, and of carcinogen application and its effects. Five different techniques of gastric surgery were performed on a collective of 466 Wistar rats: Billroth I resection, Billroth II resection, Billroth II plus gastroenterostomy with Roux-en-Y technique, Billroth II plus Braun's anastomosis, and gastroenterostomy without resection. Forty-two animals were left unoperated as controls. The appropriate date for autopsy was determined by general clinical observation and random endoscopic and radiologic examinations, and eventually fixed on the 56th postoperative week.Carcinomas developing in the resected stomach were found in animals with and without carcinogen exposure. The actual rate of carcinoma incidence was strongly dependent on the surgical procedure chosen for the respective group. The lowest carcinoma incidence (0%) was found in gastroenterostomy without Roux-en-Y anastomosis, the highest rate (70% without carcinogen, 50% with carcinogen application) in gastroenterostomy alone.Tumor development was found to be connected with alterations of the physiological environment induced by the surgical intervention; a direct association between duodenogastric reflux and tumorigenesis can be postulated. The results of the present study are interpreted with an emphasis on reflux-preventing techniques for gastric surgery that should be included in clinical routine. More... »
PAGES595-605
http://scigraph.springernature.com/pub.10.1007/bf01655015
DOIhttp://dx.doi.org/10.1007/bf01655015
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7324494
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