Sisomicin: A composite of comparative in vitro studies spanning six years View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-12

AUTHORS

C. Sanders, W. Sanders

ABSTRACT

Sisomicin is a new aminoglycoside similar to gentamicin in chemical structure and antibacterial spectrum. The in vitro activity of sisomicin, gentamicin, tobramycin, amikacin and kanamycin was determined in broth dilution assays against 310 clinical isolates which included staphylococci, enterococci, Enterobacteriaceae and non-fermenting gram-negative bacilli. Sisomicin was found to be the most predictably active agent against the gram-positive isolates. The activity of sisomicin was equal to that of gentamicin and tobramycin and significantly greater than that of amikacin or kanamycin against Escherichia coli, Enterobacter, Klebsiella, Proteus mirabilis, Proteus morganii, and Citrobacter. Sisomicin and gentamicin were the most active agents against Serratia; tobramycin was most active against Pseudomonas aeruginosa; and amikacin and kanamycin were most active against Proteus rettgeri and Providencia. For the majority of isolates minimal inhibitory concentrations of sisomicin were similar to minimal bactericidal concentrations. Organisms resistant to one of the five aminoglycosides were not necessarily resistant to the others. Zone sizes of 15 mm or more were obtained by the Bauer-Kirbytechnique with 10 µg/ml sisomicin disks for the majority of isolates inhibited by ≤ 6.2 µg/ml of the drug in broth dilution assays. Determination of bacterial killing by combinations of penicillin and sisomicin indicated a marked synergistic effect against enterococci. Results from this and other in vitro studies conducted over the past six years suggest that sisomicin possesses certain advantages over other aminoglycosides that might be extrapolated to the in vivo situation. More... »

PAGES

s317-s323

Journal

TITLE

Infection

ISSUE

Suppl 4

VOLUME

4

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01646958

DOI

http://dx.doi.org/10.1007/bf01646958

DIMENSIONS

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