Kinetic parameters of amikacin in cystic fibrosis children View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

B. Grenier, Elisabeth Autret, Sophie Marchand, Renée Thompson

ABSTRACT

Summary35 kinetic studies have been performed, in nine CF children three to 15 years old; six kinetic studies were performed in four non-CF children, one to 12 years old. The dosage was 5 to 12.5 mg/kg, i.v. during 0.5 to 1.0 h, three to four times per day. Amikacin concentrations were measured in the plasma of all children, and in the sputum of CF-patients, by fluorescent polarization (TDX Abbott). The pharmacokinetic parameters in the plasma did not differ significantly in both groups of patients. In CF children t 1/2=0.94 h (SD=0.25 h), Vd (area)=0.257 l/kg (SD=0.06 l/kg), total body clearance=130.7 ml/min/1.73 m2 (SD=32.4 ml/min/1.73 m2). In non-CF children t 1/2=0.83 h (SD=0.15 h), Vd (area)=0.265 l/kg (SD=0.04 l/kg) and clearance=155 ml/min/1.73 m2 (SD=17.4 ml/min/1.73 m2). The parameters were not affected by the dosage of amikacin. The peak plasma concentrations ranged from 19 to 43.8mg/l. Amikacin peak level in the sputum of CF children never reached the average MIC (4 mg/l) ofPseudomonas aeruginosa strains isolated in these patients. Amikacin concentration in the sputum reached its highest value about 2 h after the completion of i.v. infusion and was directly related to the peak plasma concentration. According to these parameters, the best dosage regimen appeared to be 7.5 to 8 mg/kg or 225 to 240 mg/m2 administered intravenously in 1.0 h, three times per day. More... »

PAGES

295-299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01644141

DOI

http://dx.doi.org/10.1007/bf01644141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048658291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3117703


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