Fracture risk as determined by prospective and retrospective study designs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

M. R. Stegman, R. R. Recker, K. M. Davies, R. A. Ryan, R. P. Heaney

ABSTRACT

Both retrospectively and prospectively designed studies consistently show low bone mass and/or bone mineral content (BMC) to be risk factor for low-trauma fractures in postmenopausal women. Along with the reports of such studies there has been concern expressed that BMC measurements overlap between fracture groups, i.e., some women with high BMC develop fractures and some women with low BMC do not. In these commonly used epidemiologic study designs, BMC does not discriminate between those who have and have not experienced the untoward event at some level of the exposure factor. The ability to discriminate is more properly determined by the sensitivity and specificity of the measured value. To contrast the concepts of risk and sensitivity, a nested case-control study was conducted within a 24-year cohort study of women at risk for osteoporosis. We found that for each 1.0 decrement of BMCz-scores, the adjusted relative risk for the prospective study design was 1.67, while the odds ratio obtained from the most recent BMCz-score measurements was 1.87. A receiver operating characteristic (ROC) curve, calculated from the nested case-control study data, showed that BMCz-scores, measured after low-trauma fracture, have both low sensitivity and low specificity to detect existing fracture status. More... »

PAGES

290-297

References to SciGraph publications

  • 1990-03. A critical review of bone mass and the risk of fractures in osteoporosis in CALCIFIED TISSUE INTERNATIONAL
  • 1990-08. Bone mass and osteoporotic fractures in CALCIFIED TISSUE INTERNATIONAL
  • 1989-07. Predicting fractures in women by using forearm bone densitometry in CALCIFIED TISSUE INTERNATIONAL
  • 1987-10. Quantitative computed tomography: Update 1987 in CALCIFIED TISSUE INTERNATIONAL
  • 1989-11. The predictive value of fracture, disease, and falling tendency for fragility fractures in women in CALCIFIED TISSUE INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01623185

    DOI

    http://dx.doi.org/10.1007/bf01623185

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016993434

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1421797


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