Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-05

AUTHORS

Ylermi Soini, Paavo Pääkkö, Kyösti Nuorva, Dia Kamel, David P. Lane, Kirsi Vähäkangas

ABSTRACT

In this study we analysed the expression of p53 protein in a total of 143 carcinomas immunohistochemically. These consisted of 34 prostatic adenocarcinomas, 59 lung and 50 breast carcinomas. In 28 cases, an average of 2-3 additional sections from different tumour areas were analysed. Forty-nine of the 143 carcinomas (34%) showed typical nuclear immunoreactivity by immunohistochemical staining with the p53 antibody CM-1. Two of the 34 prostatic carcinomas (6%) were p53 positive while 25 of the 59 lung carcinomas (43%) and 22 of the 50 breast carcinomas (44%) showed positivity for p53. By grade: 49% of grade III tumours, 36% of grade II and 5% of grade I tumours were p53 positive. There were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.001) when all tumours were taken into account. Further, there were significantly more p53-positive cases in grade III than in grade I-II tumours (P = 0.001). In lung tumours there were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.018). Similarly, there were significantly more p53-positive tumours in grade III breast tumours than in grade I-II tumours (P = 0.003). The low incidence of p53 positivity in prostate carcinomas suggests that mutations of the p53 gene are not as frequent in the neoplastic transformation of these tumours as in lung or breast carcinomas. The association of p53 positivity with tumours of higher grade suggests that p53 mutations lead to tumours of a more aggressive type. The analysis of tumours by multiple sections indicates that p53 positivity is not evenly distributed in tumour tissue. Therefore, analysis of additional tumour areas may reveal positivity some cases, which is not evident if only one section is studied. More... »

PAGES

223-228

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01611179

DOI

http://dx.doi.org/10.1007/bf01611179

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010358203

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1413488


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Department of Pathology, University of Oulu, Kajaanintie 52 D, SF-90220, Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soini", 
        "givenName": "Ylermi", 
        "id": "sg:person.01046241062.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046241062.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Department of Pathology, University of Oulu, Kajaanintie 52 D, SF-90220, Oulu, Finland", 
            "P\u00e4iv\u00e4rinne Hospital, Muhos, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e4\u00e4kk\u00f6", 
        "givenName": "Paavo", 
        "id": "sg:person.0614025072.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614025072.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Department of Pathology, University of Oulu, Kajaanintie 52 D, SF-90220, Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuorva", 
        "givenName": "Ky\u00f6sti", 
        "id": "sg:person.01151670313.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151670313.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Department of Pathology, University of Oulu, Kajaanintie 52 D, SF-90220, Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamel", 
        "givenName": "Dia", 
        "id": "sg:person.01010262032.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010262032.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee", 
          "id": "https://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "Cancer Research Campaign Laboratory, Medical Sciences Institute, University of Dundee, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lane", 
        "givenName": "David P.", 
        "id": "sg:person.01034432262.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034432262.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oulu", 
          "id": "https://www.grid.ac/institutes/grid.10858.34", 
          "name": [
            "Department of Pharmacology and Toxicology, University of Oulu, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00e4h\u00e4kangas", 
        "givenName": "Kirsi", 
        "id": "sg:person.0607435263.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607435263.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0140-6736(90)90801-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000123917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)90801-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000123917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)90866-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003282303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)90866-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003282303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312646a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004629945", 
          "https://doi.org/10.1038/312646a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1990.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011962573", 
          "https://doi.org/10.1038/bjc.1990.17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1990.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011962573", 
          "https://doi.org/10.1038/bjc.1990.17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711650303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017033198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1711650303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017033198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350429a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018257237", 
          "https://doi.org/10.1038/350429a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)90586-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020216543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(91)90586-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020216543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350427a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026041841", 
          "https://doi.org/10.1038/350427a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.4.6166661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029463505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/29.4.6166661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029463505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.15.5863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030364399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90045-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031705394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.12.5413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037285082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319783a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037571402", 
          "https://doi.org/10.1038/319783a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.21.7716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040664625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/342705a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041126170", 
          "https://doi.org/10.1038/342705a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312649a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045403650", 
          "https://doi.org/10.1038/312649a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910410204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046585680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.8.2.531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048065773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.22.8763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048959223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910490209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052677821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1905840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062512950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2649981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062548429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077003232", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077315964", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077661158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077685926", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077704330", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1991.tb07837.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077836682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077853439", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077853461", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077964693", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078487544", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078549112", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-05", 
    "datePublishedReg": "1992-05-01", 
    "description": "In this study we analysed the expression of p53 protein in a total of 143 carcinomas immunohistochemically. These consisted of 34 prostatic adenocarcinomas, 59 lung and 50 breast carcinomas. In 28 cases, an average of 2-3 additional sections from different tumour areas were analysed. Forty-nine of the 143 carcinomas (34%) showed typical nuclear immunoreactivity by immunohistochemical staining with the p53 antibody CM-1. Two of the 34 prostatic carcinomas (6%) were p53 positive while 25 of the 59 lung carcinomas (43%) and 22 of the 50 breast carcinomas (44%) showed positivity for p53. By grade: 49% of grade III tumours, 36% of grade II and 5% of grade I tumours were p53 positive. There were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.001) when all tumours were taken into account. Further, there were significantly more p53-positive cases in grade III than in grade I-II tumours (P = 0.001). In lung tumours there were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.018). Similarly, there were significantly more p53-positive tumours in grade III breast tumours than in grade I-II tumours (P = 0.003). The low incidence of p53 positivity in prostate carcinomas suggests that mutations of the p53 gene are not as frequent in the neoplastic transformation of these tumours as in lung or breast carcinomas. The association of p53 positivity with tumours of higher grade suggests that p53 mutations lead to tumours of a more aggressive type. The analysis of tumours by multiple sections indicates that p53 positivity is not evenly distributed in tumour tissue. Therefore, analysis of additional tumour areas may reveal positivity some cases, which is not evident if only one section is studied.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf01611179", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009231", 
        "issn": [
          "0174-7398"
        ], 
        "name": "Virchows Archiv A Pathological Anatomy and Histopathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "421"
      }
    ], 
    "name": "Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas", 
    "pagination": "223-228", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3158c2d48c1a804245cb051740335308cd242bc4ecffe464d0b7c97a63a7f9b9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1413488"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8302198"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf01611179"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010358203"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf01611179", 
      "https://app.dimensions.ai/details/publication/pub.1010358203"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46769_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF01611179"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf01611179'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf01611179'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf01611179'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf01611179'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      74 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf01611179 schema:about N06252c845d0d43db91dee434b687865e
2 N357c00d24a964f2b806d38bca8c66044
3 N47fa43fbf9a04d64bae8d5ec7875975e
4 N4ee4a244d411435cb20d797b6f584ffe
5 N8b69517c07364e8e899cf0662fe4d68a
6 N98b9911e36364ba7abc4e52d2ff6d834
7 Nab3373704aa84ec398643d12496852fb
8 Nae763b3f917a4267a6d4dd4db4589f89
9 Nba3290ff4e1943d6a95b2b829fccc4c2
10 Ne173663a347145d7a1fada7609444681
11 Ne4133d518ed44777a8381b2b9320b822
12 Nfdfa48c5461b47f7afaa845a4a84b9ca
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author Nd671a96c86114dbf8a6b8ed465490c4d
16 schema:citation sg:pub.10.1038/312646a0
17 sg:pub.10.1038/312649a0
18 sg:pub.10.1038/319783a0
19 sg:pub.10.1038/342705a0
20 sg:pub.10.1038/350427a0
21 sg:pub.10.1038/350429a0
22 sg:pub.10.1038/bjc.1990.17
23 https://app.dimensions.ai/details/publication/pub.1077003232
24 https://app.dimensions.ai/details/publication/pub.1077315964
25 https://app.dimensions.ai/details/publication/pub.1077661158
26 https://app.dimensions.ai/details/publication/pub.1077685926
27 https://app.dimensions.ai/details/publication/pub.1077704330
28 https://app.dimensions.ai/details/publication/pub.1077853439
29 https://app.dimensions.ai/details/publication/pub.1077853461
30 https://app.dimensions.ai/details/publication/pub.1077964693
31 https://app.dimensions.ai/details/publication/pub.1078487544
32 https://app.dimensions.ai/details/publication/pub.1078549112
33 https://doi.org/10.1002/ijc.2910410204
34 https://doi.org/10.1002/ijc.2910490209
35 https://doi.org/10.1002/j.1460-2075.1991.tb07837.x
36 https://doi.org/10.1002/path.1711650303
37 https://doi.org/10.1016/0092-8674(89)90045-7
38 https://doi.org/10.1016/0140-6736(90)90801-b
39 https://doi.org/10.1016/0140-6736(91)90586-e
40 https://doi.org/10.1016/0140-6736(92)90866-2
41 https://doi.org/10.1073/pnas.84.21.7716
42 https://doi.org/10.1073/pnas.86.22.8763
43 https://doi.org/10.1073/pnas.87.15.5863
44 https://doi.org/10.1073/pnas.88.12.5413
45 https://doi.org/10.1126/science.1905840
46 https://doi.org/10.1126/science.2649981
47 https://doi.org/10.1128/mcb.8.2.531
48 https://doi.org/10.1177/29.4.6166661
49 schema:datePublished 1992-05
50 schema:datePublishedReg 1992-05-01
51 schema:description In this study we analysed the expression of p53 protein in a total of 143 carcinomas immunohistochemically. These consisted of 34 prostatic adenocarcinomas, 59 lung and 50 breast carcinomas. In 28 cases, an average of 2-3 additional sections from different tumour areas were analysed. Forty-nine of the 143 carcinomas (34%) showed typical nuclear immunoreactivity by immunohistochemical staining with the p53 antibody CM-1. Two of the 34 prostatic carcinomas (6%) were p53 positive while 25 of the 59 lung carcinomas (43%) and 22 of the 50 breast carcinomas (44%) showed positivity for p53. By grade: 49% of grade III tumours, 36% of grade II and 5% of grade I tumours were p53 positive. There were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.001) when all tumours were taken into account. Further, there were significantly more p53-positive cases in grade III than in grade I-II tumours (P = 0.001). In lung tumours there were significantly more p53-positive cases in grade II-III tumours than in grade I tumours (P = 0.018). Similarly, there were significantly more p53-positive tumours in grade III breast tumours than in grade I-II tumours (P = 0.003). The low incidence of p53 positivity in prostate carcinomas suggests that mutations of the p53 gene are not as frequent in the neoplastic transformation of these tumours as in lung or breast carcinomas. The association of p53 positivity with tumours of higher grade suggests that p53 mutations lead to tumours of a more aggressive type. The analysis of tumours by multiple sections indicates that p53 positivity is not evenly distributed in tumour tissue. Therefore, analysis of additional tumour areas may reveal positivity some cases, which is not evident if only one section is studied.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N3ad025f97c89431a8530dcf839cd3ce4
56 Nb33e924384a542519ada192411593ebe
57 sg:journal.1009231
58 schema:name Comparative analysis ofp53 protein immunoreactivity in prostatic, lung and breast carcinomas
59 schema:pagination 223-228
60 schema:productId N2b0eacbf41f24e309b0e3fc898450365
61 N3c67beedef974962942bae2da3e7b553
62 N47000dc785964a149a6297f192f1c80e
63 N87ea8e200e9f49f2a7c2ea54f9fefcaf
64 N8c80b915421d4cf195af9a8876d530d0
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010358203
66 https://doi.org/10.1007/bf01611179
67 schema:sdDatePublished 2019-04-11T13:33
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nf086a88ff525483397511a8c629ad1d0
70 schema:url http://link.springer.com/10.1007/BF01611179
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N06252c845d0d43db91dee434b687865e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Carcinoma
76 rdf:type schema:DefinedTerm
77 N10955ed574da4470bcf997c275f2cf83 rdf:first sg:person.0607435263.02
78 rdf:rest rdf:nil
79 N2b0eacbf41f24e309b0e3fc898450365 schema:name dimensions_id
80 schema:value pub.1010358203
81 rdf:type schema:PropertyValue
82 N357c00d24a964f2b806d38bca8c66044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Male
84 rdf:type schema:DefinedTerm
85 N3ad025f97c89431a8530dcf839cd3ce4 schema:volumeNumber 421
86 rdf:type schema:PublicationVolume
87 N3b06cede93c34e6c98e6cf4cd403f01f rdf:first sg:person.0614025072.73
88 rdf:rest N9b1bc6e67d104eb9871c1940d7834998
89 N3c67beedef974962942bae2da3e7b553 schema:name nlm_unique_id
90 schema:value 8302198
91 rdf:type schema:PropertyValue
92 N47000dc785964a149a6297f192f1c80e schema:name doi
93 schema:value 10.1007/bf01611179
94 rdf:type schema:PropertyValue
95 N47fa43fbf9a04d64bae8d5ec7875975e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Breast Neoplasms
97 rdf:type schema:DefinedTerm
98 N4ee4a244d411435cb20d797b6f584ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Biomarkers, Tumor
100 rdf:type schema:DefinedTerm
101 N6f6dff72e89e4594b4fa33de72ee4916 rdf:first sg:person.01010262032.34
102 rdf:rest Na21ba28950e24bcf96f36ef4415c4b08
103 N87ea8e200e9f49f2a7c2ea54f9fefcaf schema:name readcube_id
104 schema:value 3158c2d48c1a804245cb051740335308cd242bc4ecffe464d0b7c97a63a7f9b9
105 rdf:type schema:PropertyValue
106 N8b69517c07364e8e899cf0662fe4d68a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Lung Neoplasms
108 rdf:type schema:DefinedTerm
109 N8c80b915421d4cf195af9a8876d530d0 schema:name pubmed_id
110 schema:value 1413488
111 rdf:type schema:PropertyValue
112 N98b9911e36364ba7abc4e52d2ff6d834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Adenocarcinoma
114 rdf:type schema:DefinedTerm
115 N9b1bc6e67d104eb9871c1940d7834998 rdf:first sg:person.01151670313.18
116 rdf:rest N6f6dff72e89e4594b4fa33de72ee4916
117 Na21ba28950e24bcf96f36ef4415c4b08 rdf:first sg:person.01034432262.26
118 rdf:rest N10955ed574da4470bcf997c275f2cf83
119 Nab3373704aa84ec398643d12496852fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Immunohistochemistry
121 rdf:type schema:DefinedTerm
122 Nae763b3f917a4267a6d4dd4db4589f89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Genes, Tumor Suppressor
124 rdf:type schema:DefinedTerm
125 Nb33e924384a542519ada192411593ebe schema:issueNumber 3
126 rdf:type schema:PublicationIssue
127 Nba3290ff4e1943d6a95b2b829fccc4c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 Nd671a96c86114dbf8a6b8ed465490c4d rdf:first sg:person.01046241062.55
131 rdf:rest N3b06cede93c34e6c98e6cf4cd403f01f
132 Ne173663a347145d7a1fada7609444681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Prostatic Neoplasms
134 rdf:type schema:DefinedTerm
135 Ne4133d518ed44777a8381b2b9320b822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 Nf086a88ff525483397511a8c629ad1d0 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Nfdfa48c5461b47f7afaa845a4a84b9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Tumor Suppressor Protein p53
142 rdf:type schema:DefinedTerm
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
147 schema:name Oncology and Carcinogenesis
148 rdf:type schema:DefinedTerm
149 sg:journal.1009231 schema:issn 0174-7398
150 schema:name Virchows Archiv A Pathological Anatomy and Histopathology
151 rdf:type schema:Periodical
152 sg:person.01010262032.34 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
153 schema:familyName Kamel
154 schema:givenName Dia
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010262032.34
156 rdf:type schema:Person
157 sg:person.01034432262.26 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
158 schema:familyName Lane
159 schema:givenName David P.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034432262.26
161 rdf:type schema:Person
162 sg:person.01046241062.55 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
163 schema:familyName Soini
164 schema:givenName Ylermi
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046241062.55
166 rdf:type schema:Person
167 sg:person.01151670313.18 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
168 schema:familyName Nuorva
169 schema:givenName Kyösti
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151670313.18
171 rdf:type schema:Person
172 sg:person.0607435263.02 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
173 schema:familyName Vähäkangas
174 schema:givenName Kirsi
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607435263.02
176 rdf:type schema:Person
177 sg:person.0614025072.73 schema:affiliation https://www.grid.ac/institutes/grid.10858.34
178 schema:familyName Pääkkö
179 schema:givenName Paavo
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614025072.73
181 rdf:type schema:Person
182 sg:pub.10.1038/312646a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004629945
183 https://doi.org/10.1038/312646a0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/312649a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045403650
186 https://doi.org/10.1038/312649a0
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/319783a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037571402
189 https://doi.org/10.1038/319783a0
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/342705a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041126170
192 https://doi.org/10.1038/342705a0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/350427a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026041841
195 https://doi.org/10.1038/350427a0
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/350429a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018257237
198 https://doi.org/10.1038/350429a0
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/bjc.1990.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011962573
201 https://doi.org/10.1038/bjc.1990.17
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1077003232 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1077315964 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1077661158 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1077685926 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1077704330 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1077853439 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1077853461 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1077964693 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078487544 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1078549112 schema:CreativeWork
213 https://doi.org/10.1002/ijc.2910410204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046585680
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/ijc.2910490209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052677821
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/j.1460-2075.1991.tb07837.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077836682
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/path.1711650303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017033198
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0092-8674(89)90045-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031705394
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0140-6736(90)90801-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1000123917
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0140-6736(91)90586-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1020216543
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0140-6736(92)90866-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003282303
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.84.21.7716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040664625
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.86.22.8763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048959223
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.87.15.5863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030364399
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.88.12.5413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037285082
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1126/science.1905840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062512950
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/science.2649981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062548429
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1128/mcb.8.2.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048065773
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1177/29.4.6166661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029463505
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.10858.34 schema:alternateName University of Oulu
246 schema:name Department of Pathology, University of Oulu, Kajaanintie 52 D, SF-90220, Oulu, Finland
247 Department of Pharmacology and Toxicology, University of Oulu, Finland
248 Päivärinne Hospital, Muhos, Finland
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.8241.f schema:alternateName University of Dundee
251 schema:name Cancer Research Campaign Laboratory, Medical Sciences Institute, University of Dundee, Dundee, UK
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...