Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-09

AUTHORS

A. Tunnacliffe, P. Goodfellow, G. Banting, E. Solomon, B. B. Knowles, P. Andrews

ABSTRACT

We have mapped two new genes to chromosome 11 which control the cell-surface expression of two distinct antigens defined by monoclonal antibodies. One of the antigens has a general tissue distribution and is associated with a molecular complex of two polypeptides of 80,000 dalton and 40,000 dalton molecular weight. The second antigen has a restricted tissue distribution and is carried on a polypeptide of 100,000 daltons. We have used a combination of genetic and biochemical techniques to demonstrate that these new markers are distinct from the antigens defined by the monoclonal antibodies F10.44.2 and W6/34 which are also encoded by genes on chromosome 11. It is concluded that human chromosome 11 carries at least four distinct genes controlling cell-surface antigen expression. More... »

PAGES

629-642

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01574263

    DOI

    http://dx.doi.org/10.1007/bf01574263

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033937516

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6623314


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