Demonstration of the presence of an inducibleβ-lactamase inAzospirillum lipoferum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-01

AUTHORS

Silvana B. Boggio, Juan C. Diaz Ricci, Diego de Mendoza, Oscar A. Roveri

ABSTRACT

Azospirillum lipoferum is a soil microorganism that has been shown to be resistant to penicillins. It has been suggested that resistance is due to the presence of a β-lactamase activity, but no conclusive evidence has been reported. The incubation of benzylpenicillin, or nitrocephin with either wholeAzospirillum cells or cell-free extracts was accompanied, by hydrolysis of the β-lactam ring of the antibiotics. Such hydrolytic activity exhibited Michaelis and Menten-like kinetics. The enzyme was produced at a low, basal level that was increased approximately 50 times by the addition of benzylpenicillin, an increase that was completely blocked by chloramphenicol or rifampicin. More... »

PAGES

33-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01568827

DOI

http://dx.doi.org/10.1007/bf01568827

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050768135


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