Superoxide anions are required for the inactivation ofEscherichia coli induced by high concentrations of hydrogen peroxide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-03

AUTHORS

Giorgio Brandi, Giuditta F. Schiavano, Mauro Magnani, Amedeo Albano, Flaminio Cattabeni, Orazio Cantoni

ABSTRACT

The wild-type strain and mutants ofEscherichia coli lacking Mn-superoxide dismutase (Sod A) or Fe-superoxide dismutase (Sod B) are compared for their sensitivity to the H2O2 insult (exposure for 15 min at 37°C, in M9 salts). Whereas mode one killing is similar in superoxide dismutase mutants and wild-type cells, the latter strain appears to be more resistant than the former ones to mode two lethality. Furthermore, Sod B cells, as well as wild-type cells but unlike Sod A cells, are capable of reversing the toxicity of the oxidant (even in the presence of chloramphenicol), this effect being observed by gradually increasing the H2O2 concentration from 2.5 to 10 mM. It is concluded that (a) superoxide ions may not be involved in the production of mode one killing by H2O2, although further experiments are needed to validate or modify this hypothesis; (b) superoxide ions mediate mode two killing by H2O2, possibly by reducing trivalent iron to the divalent form; and (c) the intervening zone of partial resistance observed in wild-type and Sod B cells exposed to intermediate H2O2 concentrations is not a consequence of Mn-superoxide dismutase induction; it would appear, however, that cells lacking this superoxide dismutase isoenzyme are not proficient in this acquired response. More... »

PAGES

117-120

Journal

TITLE

Current Microbiology

ISSUE

2

VOLUME

17

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01568796

DOI

http://dx.doi.org/10.1007/bf01568796

DIMENSIONS

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