Activation of natural killer (NK) cells in vivo with H-2 and non-H-2 alloantigens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-12

AUTHORS

Edward A. Clark, Richard D. Holly

ABSTRACT

Intraperitoneal inoculation of allogeneic lymphoid cells rapidly activates cytotoxic cells in the peritoneum which are nonadherent and express the NK-1, asialo-GM1, and Thy-1 antigens. Allogeneic spleen cells were very efficient at activating these natural killer (NK) cells, while allogeneic thymocytes were much less effective. Heat-killed allogeneic cells or sonicates also could augment NK activity. — Incompatibility atH-2K, H-2I-A, orH- 2D readily evoked NK cell activity, whileH-2S- andH-2I-E/C-associated disparities did not. Non-H- 2 differences also stimulated NK activity and augmentation was particularly evident inMls-disparate combinations. Thus, the same alloantigens which efficiently activate T cells also activate NK cells. More... »

PAGES

221-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01561666

DOI

http://dx.doi.org/10.1007/bf01561666

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025035922

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7203558


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