Differential inhibition of the MLR by iron: Association with HLA phenotype View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-12

AUTHORS

Christopher F. Bryan, Koji Nishiya, Marilyn S. Pollack, Bo Dupont, Maria de Sousa

ABSTRACT

The effect of iron on the MLR was examined by pretreating peripheral blood mononuclear cells from 77 unrelated Caucasians with five concentrations of Ferric-citrate (10.0 mM, 1.0 mM, 0.1 mM, 0.01 mM and 0.005 mM). After incubation with the metal, the cells were washed and cultured in a one-way MLR with a pool of stimulator cells. Cell viability remained unchanged (greater than 90 percent) during the 6-day culture period. Citrate per se had no effect on either the responder or the stimulator population. Iron treatment influenced the MLR in the following ways: (1) a variable degree of inhibition was observed which related to the dose of Ferric-citrate used and to HLA phenotype, (2) the responder but not the stimulator cells were affected, (3) no statistically significant differences were seen between female and male donor cells and (4) the mean percent response of cells from HLA-A2 donors were significantly (0.005 More... »

PAGES

129-140

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01561656

DOI

http://dx.doi.org/10.1007/bf01561656

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041364481

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6451576


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