Allotransplantation of the lung in dogs with experimental lung damage View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-07

AUTHORS

Georg Salem, Werner Schlick, Alfred Keiler, Peter Möschl, Martin Glöckler, Taddäus Radaszkiewicz, Wilhelm Kreuzer

ABSTRACT

In 8 dogs, bilateral pulmonary emphysema was induced by intratracheal instillations of papain, and in 6 dogs, unilateral emphysema was induced by bronchoscopic instillation of papain in the right main bronchus. Development of emphysema was documented by weekly pulmonary function studies. Lung compliance and functional residual capacity were increased, and airway resistance was increased in forced ventilation. When emphysema was established, unilateral allotransplantation of the lung was performed. Postoperative studies of lung function showed no serious ventilation-perfusion imbalance. Ventilatory function and oxygen consumption of the graft were at least equal to the animal's own damaged lung. Respiratory insufficiency and death were always accompanied by rejection or severe infection. It is concluded that postoperative respiratory failure was not due to difference of airway and vascular resistance between the damaged lung and the graft. More... »

PAGES

511-514

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01556121

DOI

http://dx.doi.org/10.1007/bf01556121

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010005067

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/390896


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