Soluble Fas molecule in the serum of patients with systemic lupus erythematosus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-09

AUTHORS

Yoshiaki Tokano, Sachiko Miyake, Nobuhiko Kayagaki, Kazuhisa Nozawa, Shinji Morimoto, Miyuki Azuma, Hideo Yagita, Yoshinari Takasaki, Ko Okumura, Hiroshi Hashimoto

ABSTRACT

The serum level of soluble Fas (sFas) molecules in 35 patients with SLE was determined by enzyme-linked immunosorbent assay (ELISA) and its relation to other lymphocyte activation markers and clinical parameters was examined. The level of sFas increased significantly compared to that in normal subjects, consistent with previous reports. There was a significant correlation between the level of sFas and that of sCD4, suggesting some relation between sFas and activation of CD4+ T cell. Patients with lymphopenia tended to have low levels of sFas, making it possible to hypothesize that sFas protects against apoptosis. Although the change in the level of sFas protects steroid therapy was variable, some relation to the differential activation of T cell subsets was suggested. More... »

PAGES

261-265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf01541390

DOI

http://dx.doi.org/10.1007/bf01541390

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049082246

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8886994


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