CpG DNA: A pathogenic factor in systemic lupus erythematosus? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-11

AUTHORS

Arthur M. Krieg

ABSTRACT

Systemic lupus erythematosus (SLE) is a multifactorial disease of unknown etiology. Characteristic features of SLE include (1) polyclonal B cell activation, (2) overexpression of the immune stimulatory cytokine interleukin-6 (IL-6), (3) defective tolerance to self antigens, and (4) production of anti-DNA antibodies (Ab). Bacterial infection has been suspected as a triggering factor for lupus. Bacterial DNA differs from vertebrate DNA in the frequency and methylation of CpG dinucleotides. These CpG motifs in bacterial DNA induce a variety of immune effects, including (1) polyclonal activation of murine and human B cells, (2) IL-6 secretion, and (3) resistance to apoptosis, thereby potentially allowing the survival of autoreactive cells. These results suggest that microbial DNA could therefore be a pathogenic factor in SLE. SLE patients have elevated levels of circulating plasma DNA which is reportedly enriched in hypomethylated CpGs. Genomic DNA is also hypomethylated in SLE. The purpose of this review is to summarize the immune effects of CpG motifs and to present the evidence for their possible involvement in the pathogenesis of SLE. More... »

PAGES

284-292

Journal

TITLE

Journal of Clinical Immunology

ISSUE

6

VOLUME

15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf01541318

    DOI

    http://dx.doi.org/10.1007/bf01541318

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040661332

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8576314


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